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Fasenra vs. Nucala

Reviewed on 10/15/2020

Are Fasenra and Nucala the Same Thing?

Fasenra (benralizumab) injection and Nucala (mepolizumab) for injection are interleukin-5 receptor alpha-directed cytolytic monoclonal antibodies (IgG1, kappa) used for add-on maintenance treatment of patients with severe asthma aged 12 years and older, and with an eosinophilic phenotype.

Nucala is also used to treat adult patients with eosinophilic granulomatosis with polyangiitis (EGPA) and to treat adult and pediatric patients aged 12 years and older with hypereosinophilic syndrome (HES) for 6 or more months without an identifiable non-hematologic secondary cause.

Side effects of Fasenra and Nucala that are similar include headache, and injection site reactions (pain, redness, itching, or a small lump).

Side effects of Fasenra that are different from Nucala include sore throat, fever, and hypersensitivity reactions.

Side effects of Nucala that are different from Fasenra include back pain, fatigue, flu symptoms, urinary tract infection (UTI), abdominal pain, itching, eczema, and muscle spasms.

Both Fasenra and Nucala may interact with other drugs.

QUESTION

Asthma is a chronic respiratory disease. See Answer

What Are Possible Side Effects of Fasenra?

Common side effects of Fasenra include:

  • headache,
  • sore throat,
  • fever,
  • hypersensitivity reactions, and
  • injection site reactions (pain, redness, itching, or a small lump)

What Are Possible Side Effects of Nucala?

Common side effects of Nucala include:

What Is Fasenra?

Fasenra (benralizumab) injection is an interleukin-5 receptor alpha-directed cytolytic monoclonal antibody (IgG1, kappa) indicated for the add-on maintenance treatment of patients with severe asthma aged 12 years and older, and with an eosinophilic phenotype.

What Is Nucala?

Nucala (mepolizumab) is an interleukin-5 (IL-5) antagonist monoclonal antibody (IgG1 kappa) indicated for add-on maintenance treatment of patients with severe asthma aged 6 years and older, and with an eosinophilic phenotype; the treatment of adult patients with eosinophilic granulomatosis with polyangiitis (EGPA); and the treatment of adult and pediatric patients aged 12 years and older with hypereosinophilic syndrome (HES) for 6 or more months without an identifiable non-hematologic secondary cause.

What Drugs Interact With Fasenra?

Fasenra may interact with other drugs. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Fasenra; it is unknown how it would affect a fetus. Monoclonal antibodies such as Fasenra are transported across the placenta during the third trimester of pregnancy; therefore, potential effects on a fetus are likely to be greater during the third trimester of pregnancy. It is unknown if Fasenra passes into breast milk or how it would affect a nursing infant. Consult your doctor before breastfeeding.

What Drugs Interact With Nucala?

Nucala may interact with other drugs. Tell your doctor all medications and supplements you use.

SLIDESHOW

What Is Asthma? Symptoms, Causes, and Treatments See Slideshow

How Should Fasenra Be Taken?

Fasenra is for subcutaneous use only.

The recommended dose of Fasenra is 30 mg administered once every 4 weeks for the first 3 doses, and then once every 8 weeks thereafter by subcutaneous injection into the upper arm, thigh, or abdomen.

How Should Nucala Be Taken?

The dose of Nucala is 100 mg administered subcutaneously once every 4 weeks. Nucala may interact with other drugs. Tell your doctor all medications and supplements you use.

Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA). 

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs. 

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current. 

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.    

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
AstraZeneca. Fasenra Product Monograph.

https://www.fasenra.com

GSK. Nucala Drug Information.

https://www.nucala.com/

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