Reviewed on 4/11/2023

What Is Felodipine and How Does It Work?

Felodipine is a calcium channel blocker used to treat hypertension (high blood pressure).

  • Felodipine is available under the following different brand names: Cabren, Cardioplen XL, Felendil XL, Felogen XL, Felotens XL, Keloc SR, Neofel XL, Plendil, Renedil, and Vascalpha.

What Are Dosages of Felodipine?

Dosages of Felodipine:

Dosage Forms and Strengths

Tablets, extended-release

  • 2.5 mg
  • 5 mg
  • 10 mg

Dosage Considerations – Should be Given as Follows:



  • Initial 2.5-5 mg orally once/day
  • Maintenance: 2.5-10 mg orally once/day; some recommend up to 20 mg/day


  • Initial dose: 2.5 mg orally once/day; dosage should be adjusted according to patient response, and any increase made at intervals of at least 2 weeks
  • The maximum dosage is 10 mg orally once/day

Hypertension, Pediatric (Off-label)

  • Initial 2.5 mg orally once/day; no more than 10 mg orally once/day

Hepatic Impairment

  • Initial: 2.5 mg orally once/day

Other Indications and Uses

What Are Side Effects Associated with Using Felodipine?

Common side effects of felodipine include:

  • Headache
  • Flushing (warmth, redness, or tingly feeling under your skin)
  • Dizziness
  • Fast heart rate
  • Lightheadedness
  • Stomach upset as your body adjusts to the medication

Other side effects of felodipine include:

  • Gum inflammation
  • Rash
  • Upper respiratory infection
  • Drowsiness
  • Weakness
  • Restlessness
  • Nervousness
  • Nausea
  • Constipation
  • Diarrhea
  • Stomach pain
  • Sleep problems (insomnia)
  • Joint pain or muscle cramps
  • Urinating more than usual
  • Cold symptoms such as stuffy nose, sneezing, and sore throat

Serious side effects of Plendil including:

  • Swelling of the hands/ankles/feet (edema)
  • Fast or irregular heartbeat

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Felodipine?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Severe interactions of felodipine include:
    • dantrolene
    • itraconazole
  • Serious interactions of felodipine include:
    • carbamazepine
    • cholic acid
    • cimetidine
    • erythromycin base
    • erythromycin ethylsuccinate
    • erythromycin lactobionate
    • erythromycin stearate
    • everolimus
    • idelalisib
    • ivacaftor
    • ketoconazole
    • nefazodone
    • rifabutin
    • rifampin
    • St. John's wort
    • topotecan
    • venetoclax
  • Felodipine has moderate interactions with at least 186 different drugs.
  • Felodipine has mild interactions with at least 39 different drugs.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns, or for more information about this medicine.

What Are Warnings and Precautions for Felodipine?


This medication contains felodipine. Do not take Cabren, Cardioplen XL, Felendil XL, Felogen XL, Felotens XL, Keloc SR, Neofel XL, Plendil, Renedil, or Vascalpha if you are allergic to felodipine or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.


  • Hypersensitivity

Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Felodipine?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Felodipine?"


  • Congestive heart failure (CHF), aortic stenosis, hypotension (initially or after dose increases), persistent progressive dermatologic reactions, exacerbation of angina (during initiation of treatment, after a dose increase, or withdrawal of beta-blocker), liver impairment.
  • Patients with heart failure or compromised ventricular function (especially with beta-blocker).
  • Avoid taking with grapefruit juice.
  • Sustained-release product.

Pregnancy and Lactation

  • Use felodipine with caution during pregnancy if the benefits outweigh the risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.
  • Felodipine excretion in milk is unknown. It is not recommended for use while breastfeeding.

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