Fetroja vs. Cipro

Are Cipro and Fetroja the Same Thing?

Fetroja (cefiderocol) and Cipro (ciprofloxacin) are antibiotics used to treat urinary tract infections (UTIs).

Fetroja is used to treat complicated urinary tract infections (cUTIs), including pyelonephritis caused by susceptible Gram-negative microorganisms.

Cipro is also used to treat infections of the skin, lungs, airways, bones, and joints.

Fetroja and Cipro are different types of antibiotics. Fetroja is a cephalosporin antibiotic and Cipro is a quinolone antibiotic.

Side effects of Fetroja and Cipro that are similar include diarrhea, rash, headache, nausea, and vomiting.

Side effects of Fetroja that are different from Cipro include infusion site reactions, constipation, candidiasis (oral thrush or vaginal yeast infections), cough, elevations in liver tests, and low blood potassium (hypokalemia).

Side effects of cipro that are different from Fetroja include dizziness, drowsiness, stomach upset, abdominal pain, blurred vision, nervousness, anxiety, agitation, and sleep problems (insomnia or nightmares).

Fetroja may interact with other drugs.

Cipro may interact with the ulcer medicine sucralfate, antacids (that contain calcium, magnesium, or aluminum), didanosine powder or chewable tablets, lanthanum carbonate or sevelamer; vitamin or mineral supplements that contain calcium, iron, magnesium, or zinc; cyclosporine, methotrexate, metoclopramide, phenytoin, probenecid, ropinirole, sildenafil, theophylline, blood thinners, diuretics ("water pills"), heart rhythm medications, insulin or oral diabetes medicines, medicines to treat depression or mental illness, steroids, and nonsteroidal anti-inflammatory drugs (NSAIDs).

What Are Possible Side Effects of Fetroja?

Common side effects of Fetroja include:

  • diarrhea,
  • infusion site reactions,
  • constipation,
  • rash,
  • candidiasis (oral thrush or vaginal yeast infections),
  • cough,
  • elevations in liver tests,
  • headache,
  • low blood potassium (hypokalemia),
  • nausea, and
  • vomiting

What Are Possible Side Effects of Cipro?

Common side effects of Cipro include:

  • diarrhea
  • dizziness
  • drowsiness
  • headache
  • stomach upset
  • abdominal pain
  • nausea/vomiting
  • blurred vision
  • nervousness
  • anxiety
  • agitation
  • sleep problems (insomnia or nightmares), and
  • rash

What is Fetroja?

Fetroja (cefiderocol) is a cephalosporin antibacterial used to treat patients 18 years of age or older who have limited or no alternative treatment options, for the treatment of complicated urinary tract infections (cUTI), including pyelonephritis caused by susceptible Gram-negative microorganisms.

What is Cipro?

Cipro (ciprofloxacin) is a quinolone antibiotic. Cipro is available as a generic drug and is prescribed to treat infections of the skin, lungs, airways, bones, joints, and urinary tract infections caused by susceptible bacteria.

What Drugs Interact With Fetroja?

Fetroja may interact with other medicines.

Tell your doctor all medications and supplements you use.

What Drugs Interact With Cipro?

Cipro may interact with blood thinners, cyclosporine, or seizure medicines.

Cipro may also interact with tizanidine, clozapine, glyburide, methotrexate, metoclopramide, probenecid, ropinirole, theophylline, nonsteroidal anti-inflammatory drugs (NSAIDs), or steroids.

How Should Fetroja Be Taken?

The dose of Fetroja for injection is 2 grams administered every 8 hours by intravenous (IV) infusion over 3 hours in patients with creatinine clearance (CLcr) 60 to 119 mL/min.

How Should Cipro Be Taken?

Dosage of Cipro ranges from 500 mg once every 24 hours for 3 days for uncomplicated infections, to 1000 mg once every 24 hours for 7-14 days for complicated or acute infections.

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References
FDA. Fetroja Product Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/209445s000lbl.pdf

FDA. Cipro Product Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/019537s68,19847s42,19857s49,20780s26,21473s24lbl.pdf

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