Fioricet vs. Midrin

Are Fioricet and Midrin the Same Thing?

Fioricet (butalbital, acetaminophen, and caffeine capsule) and Midrin (isometheptene mucate, dichloralphenazone and acetaminophen) are combination medications used to treat severe tension headaches.

Midrin is also used to treat migraine headaches.

Fioricet and Midrin are different combinations of medications. Fioricet is a combination of a barbiturate, a non-salicylate analgesic (pain reliever) and antipyretic (fever reducer), and a central nervous system stimulant, and Midrin is a combination of a pain reliever and fever reducer, a sedative, and a vasoconstrictor.

The brand name Midrin is no longer manufactured, but generic versions may be available.

What Are Possible Side Effects of Fioricet?

Common side effects of Fioricet include:

What Are Possible Side Effects of Midrin?

Common side effects of Midrin include:

  • dizziness,
  • drowsiness,
  • mood changes, and
  • nausea.

What is Fioricet?

Fioricet (butalbital, acetaminophen, and caffeine capsule) is a combination of a barbiturate, a non-salicylate analgesic and antipyretic, and a central nervous system stimulant indicated for the relief of the symptom complex of tension (or muscle contraction) headache.

What is Midrin?

Midrin (isometheptene mucate, dichloralphenazone and acetaminophen) is a combination of a pain reliever and fever reducer, a sedative, and a vasoconstrictor used to treat migraine headaches or severe tension headaches. The brand name Midrin is no longer manufactured, but generic versions may be available.

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What Drugs Interact With Fioricet?

Fioricet may interact with monoamine oxidase (MAO) inhibitors, other narcotic analgesics, alcohol, general anesthetics, tranquilizers such as chlordiazepoxide, sedative-hypnotics, or other CNS depressants.

What Drugs Interact With Midrin?

Midrin or equivalent medications may interact with blood thinners, isoniazid, or antidepressants. Acetaminophen is contained in many combination medicines. Read all labels carefully so you don't take too much acetaminophen. Tell your doctor all medications you are taking.

How Should Fioricet Be Taken?

The dose of Fioricet is one or two capsules every four hours. The total daily dosage of Fioricet should not exceed 6 capsules.

How Should Midrin Be Taken?

The usual adult dosage of Midrin is two capsules at once, followed by one capsule every hour until relieved, up to 5 capsules within a 12-hour period.

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