Flagyl vs. Xifaxan

Are Flagyl and Xifaxan the Same Thing?

Flagyl, Flagyl ER, and Flagyl Injection (metronidazole) and Xifaxan (rifaximin) are antibiotics used to treat small intestine bacterial overgrowth (SIBO).

Flagyl, is also used to treat bacterial vaginosis, trichomonas, amebiasis, and anaerobic bacterial infections.

Xifaxan (rifaximin) is also used to treat travelers' diarrhea caused by noninvasive strains of Escherichia coli (E. coli), and to lower the risk of worsened brain function, or hepatic encephalopathy, in adults with liver failure.

What Are Possible Side Effects of Flagyl?

Side effects of Flagyl include:

Uncomfortable side effects that may become serious are:

  • fevers,
  • pain with urination,
  • mouth sores,
  • tingling or pricking sensations that may become permanent,
  • brain disease, and
  • seizures.

Serious but unlikely side effects of Flagyl include:

What Are Possible Side Effects of Xifaxan?

Common side effects of Xifaxan include:

  • nausea,
  • vomiting,
  • constipation,
  • bloating,
  • gas,
  • stomach pain,
  • feeling like you need to urgently empty your bowel,
  • feeling your bowel is not completely empty,
  • headache,
  • dizziness,
  • tired feeling, or
  • swelling in your hands, feet, or torso.

Tell your doctor if you develop serious side effects of Xifaxan including:

  • persistent diarrhea,
  • abdominal or stomach pain or cramping, or
  • blood or mucus in your stool.

What is Flagyl?

Flagyl, Flagyl ER, and Flagyl Injection (metronidazole) are antimicrobial drugs used to treat bacterial vaginosis, trichomonas, amebiasis, and anaerobic bacterial infections.

What is Xifaxan?

What is Xifaxan?

Xifaxan (rifaximin) is an antibiotic indicated for the treatment of patients 12 years of age and older with travelers' diarrhea caused by noninvasive strains of Escherichia coli (E. coli), and to lower the risk of worsened brain function, or hepatic encephalopathy, in adults with liver failure.

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Digestive Disorders: Common Misconceptions See Slideshow

What Drugs Interact With Flagyl?

Flagyl may interact with blood thinners or seizure medications.

Flagyl may also interact with cimetidine, lithium, or disulfiram.

What Drugs Interact With Xifaxan?

Xifaxan may interact with other drugs. Tell your doctor all medications and supplements you use.

How Should Flagyl Be Taken?

Flagyl is supplied in 250 and 500 mg strength tablets, Flagyl ER is available in 750 mg strength tablets, and Flagyl Injection in 500 mg strength in a buffered 100 ml vial. Dosage is quite variable and dependent upon the severity of disease and other considerations made by the treating physician. Most of the serious side effects may occur with any of these three preparations of Flagyl. Flagyl may cause liver enzyme levels to increase; lithium and creatinine levels should be checked to avoid lithium toxicity or renal compromise. Alcohol may increase the side effects of Flagyl. Patients on disulfiram should not take Flagyl until they have had a two week interval without taking disulfiram, especially alcoholic patients, to avoid psychotic reactions. Treatment in pregnant women (during first 3 months is not advised) or women who are breastfeeding should only be done if the benefits outweigh the potential problems. Flagyl passes into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding. Except for use in amebiasis, studies in pediatric patients are not available; Flagyl ER has no pediatric studies.

How Should Xifaxan Be Taken?

Xifaxan (rifaximin) tablets for oral administration are film-coated and contain 200 or 550 mg of rifaximin. Usual dosage is 200 mg three times a day for three days for diarrhea and 550mg twice a day for 3 days for hepatic encephalopathy.

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References


DailyMed. Flagyl Product Monograph.

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a2883ca1-5a9a-4259-9d80-46ab67274384

Salix Pharmaceuticals. Xifaxan Product Monograph.

https://www.xifaxan.com

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