Flagyl vs. Zosyn

Are Flagyl and Zosyn the Same Thing?

Flagyl, Flagyl ER, and Flagyl Injection (metronidazole) and Zosyn (piperacillin and tazobactam for injection) are antibiotics used to treat bacterial infections.

Flagyl and Zosyn are different types of antibiotics. Flagyl is a nitroimidazole antibiotic and Zosyn is a combination of a penicillin-class antibacterial and a beta-lactamase inhibitor.

What Are Possible Side Effects of Flagyl?

Side effects of Flagyl include:

Uncomfortable side effects that may become serious are:

  • fevers,
  • pain with urination,
  • mouth sores,
  • tingling or pricking sensations that may become permanent,
  • brain disease, and
  • seizures.

Serious but unlikely side effects of Flagyl include:

What Are Possible Side Effects of Zosyn?

Common side effects of Zosyn include:

Tell your doctor if you have serious side effects of Zosyn including muscle cramps or spasms, swelling of the arms/legs/hands/feet, easy bruising or bleeding, chest pain, confusion, new signs of infection (such as fever, persistent sore throat), severe abdominal or stomach pain, slow/fast/irregular heartbeat, persistent nausea or vomiting, seizures, extreme tiredness, dark or cloudy urine, change in the amount of urine, yellowing eyes or skin, or serious skin reactions (rash, peeling, sores, or blisters).

What is Flagyl?

Flagyl, Flagyl ER, and Flagyl Injection (metronidazole) are antimicrobial drugs used to treat bacterial vaginosis, trichomonas, amebiasis, and anaerobic bacterial infections.

What is Zosyn?

What is Zosyn?

Zosyn (piperacillin and tazobactam for injection) is a combination of two antibiotics used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, skin infections, and pneumonia..

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What Drugs Interact With Flagyl?

Flagyl may interact with blood thinners or seizure medications.

Flagyl may also interact with cimetidine, lithium, or disulfiram.

What Drugs Interact With Zosyn?

Zosyn may interact with medication to prevent blood clots, probenecid, or other antibiotic.

How Should Flagyl Be Taken?

Flagyl is supplied in 250 and 500 mg strength tablets, Flagyl ER is available in 750 mg strength tablets, and Flagyl Injection in 500 mg strength in a buffered 100 ml vial. Dosage is quite variable and dependent upon the severity of disease and other considerations made by the treating physician. Most of the serious side effects may occur with any of these three preparations of Flagyl. Flagyl may cause liver enzyme levels to increase; lithium and creatinine levels should be checked to avoid lithium toxicity or renal compromise. Alcohol may increase the side effects of Flagyl. Patients on disulfiram should not take Flagyl until they have had a two week interval without taking disulfiram, especially alcoholic patients, to avoid psychotic reactions. Treatment in pregnant women (during first 3 months is not advised) or women who are breastfeeding should only be done if the benefits outweigh the potential problems. Flagyl passes into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding. Except for use in amebiasis, studies in pediatric patients are not available; Flagyl ER has no pediatric studies.

How Should Zosyn Be Taken?

The usual total daily dose of Zosyn for adults is 3.375 g every six hours totaling 13.5 g (12.0 g piperacillin/1.5 g tazobactam).

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References
Medical Editor: John P. Cunha, DO, FACOEP

SOURCE:

RxList. Flagyl Medication Guide.

https://www.rxlist.com/flagyl-drug.htm#medguide

RxList. Zosyn Medication Guide.

https://www.rxlist.com/zosyn-drug.htm#medguide

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