- What other names is Flaxseed Oil known by?
- What is Flaxseed Oil?
- How does Flaxseed Oil work?
- Are there safety concerns?
- Are there any interactions with medications?
- Dosing considerations for Flaxseed Oil.
Aceite de Linaza, Acide Alpha-Linolénique, Acide Gras N-3, Acide Gras Oméga 3, ALA, Alasi, Aliviraaii, Alpha-Linolenic Acid, Brown Flaxseed Oil, Brown-Seeded Flax Oil, Common Flax Oil, Echter Lein, Flachs, Flachssamen, Flax Oil, Flax Seed Oil, Golden Flax Oil, Graine de Lin, Huile de Lin, Kattan, Keten, Lin, Lin Commun, Lin Oléagineux, Linho, Lino, Lino Comune, Lino Mazzese, Lino Usuale, Linseed Flax Oil, Linseed Oil, Linum crepitans, Linum humile, Linum usitatissimum, Malsag, N-3 Fatty Acid, Oil of Flaxseed, Omega-3 Fatty Acid, Saatlein, Ta Ma, Tisii.
Flaxseed is the seed from the plant Linum usitatissimum. Flaxseed oil and linseed oil are the oils that come from flaxseed. Linseed oil is usually used in manufacturing, while flaxseed oil is used to benefit nutrition. Flaxseed oil contains the essential omega-3 fatty acid alpha-linolenic acid (ALA).
People take flaxseed oil by mouth for constipation, osteoarthritis, pneumonia, rheumatoid arthritis, cancers including breast cancer and prostate cancer, anxiety, benign prostatic hyperplasia (BPH), vaginal infections, attention deficit-hyperactivity disorder (ADHD), bipolar disorder, exercise performance, an ovary disorder called polycystic ovary syndrome (PCOS), diabetes, weight loss, hardening of the arteries (atherosclerosis), heart disease, HIV/AIDS, high triglyceride levels, high cholesterol and other fats in the blood, high blood pressure, dry skin, dry eyes, and reducing inflammation associated with a treatment for kidney disease called hemodialysis.
In foods, flaxseed oil is used in salad dressings and in margarines.
In manufacturing, flaxseed oil is used as an ingredient in paints, varnishes, linoleum, and soap; and as a waterproofing agent. When it is used for manufacturing purposes, flaxseed oil is usually referred to as linseed oil.
Possibly Effective for...
- Carpal tunnel syndrome. Research suggests that applying flaxseed oil to the wrist twice daily for 4 weeks improves symptoms and wrist function in people with carpal tunnel syndrome who wear a wrist splint at night.
Possibly Ineffective for...
- Bipolar disorder. Research suggests that taking flaxseed oil daily for 16 weeks does not improve symptoms of mania or depression in children with bipolar disorder.
- Diabetes. Research suggests that flaxseed oil does not lower blood sugar or improve insulin levels in people with type 2 diabetes.
- High cholesterol. Early research suggests that taking flaxseed oil daily for 3 months lowers total cholesterol in people with high cholesterol. However, this early research is not reliable. More reliable research suggests that flaxseed oil does not reduce cholesterol levels in people with high cholesterol and high triglycerides. When taken in combination with safflower oil, flaxseed oil seems to modestly reduce total and low-density lipoprotein (LDL or "bad") cholesterol in people with at least one risk factor for heart disease. But the combination of oils does not seem to work as well as canola oil that has been enriched with docosahexaenoic acid (DHA).
- Rheumatoid arthritis (RA). Taking flaxseed oil daily for 3 months does not seem to improve symptoms of pain and stiffness, and has no effect on laboratory tests that measure the severity of RA.
Insufficient Evidence to Rate Effectiveness for...
- "Hardening of the arteries" (atherosclerosis). There is some evidence that increasing the amount of linolenic acid in the diet can help to prevent hardening of the arteries. Flaxseed oil contains linolenic acid. Therefore some people suggest that flaxseed oil might prevent atherosclerosis. Though this assumption seems reasonable, there has been no research yet to prove it is correct.
- Attention deficit-hyperactivity disorder (ADHD). Early research suggests that taking flaxseed oil in combination with vitamin C might improve attention, impulsiveness, restlessness, and self-control in children with ADHD.
- Breast cancer. Women who have higher levels of alpha-linolenic acid in their breast tissue seem to be less likely to get breast cancer. Scientists think that high intake of alpha-linolenic acid might protect against breast cancer. Flaxseed oil is one source of alpha-linolenic acid. However it is not known if increasing flaxseed oil intake will help to prevent breast cancer.
- Heart disease. Men and women who consume more alpha-linolenic acid in their diet seem to have a reduced risk of having a heart attack. Also, higher dietary intake of alpha-linolenic acid seems to reduce the risk of having a second heart attack in people who have already had one heart attack. Also, people with existing heart disease who consume more alpha-linolenic acid in their diet seem to have a lower risk of dying from heart disease. Flaxseed oil is one source of alpha-linolenic acid. However, research has not directly measured the effect of flaxseed oil intake on heart disease outcomes. It is also not known if flaxseed oil supplements have the same effects as flaxseed oil from food.
- Dry eyes. Some early research suggests that taking flaxseed oil might reduce irritation and symptoms of dry eyes in people with a condition called Sjögren's syndrome. Also, using a specific product containing fish oil plus flaxseed oil (TheraTears Nutrition, Advanced Vision Research) might reduce symptoms of dry eye and increase tear production.
- Dry skin. There is inconsistent evidence about the effects of flaxseed oil for dry skin. Some research suggests that taking flaxseed oil by mouth with vitamin C daily for 12 weeks does not improve skin moisture in women with dry skin. However, other research suggests that taking flaxseed oil by mouth for the same length of time can improve skin moisture and roughness.
- Exercise performance. Lower-quality research suggests that alpha-linolenic acid, a chemical in flaxseed oil, does not improve muscle strength in older adults. It is not known if flaxseed oil affects exercise performance.
- Treatment for kidney disease called hemodialysis. Hemodialysis can result in inflammation in the body. This inflammation can lead to complications or increase the risk of death in people undergoing hemodialysis. Research suggests that taking flaxseed oil twice daily for 120 days reduces inflammation in people undergoing hemodialysis. But it's not clear if flaxseed oil directly reduces the risk of complications or death in these people.
- HIV/AIDS. Early research suggests that taking a formula containing arginine, yeast RNA, and alpha-linolenic acid, a chemical in flaxseed oil, improves weight gain, but not immune function in people with HIV. The effects of flaxseed oil alone on HIV are not clear.
- High blood pressure. There is inconsistent evidence regarding the effects of flaxseed oil on blood pressure. Population research shows that higher intake of flaxseed oil as part of the diet is linked with a lower risk of developing high blood pressure. Also, early research suggests that flaxseed oil supplements can lower blood pressure in men with high cholesterol and normal blood pressure. But it is not clear if flaxseed oil lowers blood pressure in people with high blood pressure. Also, some conflicting research suggests that dietary or supplemental flaxseed oil does not lower blood pressure.
- An ovary disorder known as polycystic ovary syndrome (PCOS). Research suggests that taking flaxseed oil for 6 weeks might lower triglyceride levels, but does not affect weight, blood sugar, or cholesterol levels in women with PCOS.
- Pneumonia. Consuming alpha-linolenic acid in the diet seems to be linked to a reduced risk of developing pneumonia. Flaxseed oil is one source of alpha-linolenic acid. However, research has not directly measured the effect of flaxseed oil intake on pneumonia outcomes. It is also not known if flaxseed oil supplements have the same effects as flaxseed oil from food.
- Prostate cancer. Research is inconsistent on the effect of the flaxseed oil ingredient, alpha-linolenic acid, in prostate cancer. Some research suggests that high dietary intake of alpha-linolenic acid is linked with an increased risk for prostate cancer. Other research suggests high intake or high blood levels of alpha-linolenic acid is not linked with the overall risk of prostate cancer. However, extra alpha-linolenic acid might make existing prostate cancer worse. The source of alpha-linolenic acid appears to be important. Alpha-linolenic acid from dairy and meat sources has been positively linked with prostate cancer. Alpha-linolenic acid from plant sources, such as flaxseed or flaxseed oil, does not affect prostate cancer risk.
- Vaginal problems.
- Weight loss.
- Other conditions.
Flaxseed oil is a source of polyunsaturated fatty acids such as alpha-linolenic acid. The alpha-linolenic acid and related chemicals in flaxseed oil seem to decrease inflammation. That is why flaxseed oil is thought to be useful for rheumatoid arthritis and other inflammatory (swelling) diseases.
Flaxseed oil is LIKELY SAFE for most adults when taken by mouth appropriately short-term. Flaxseed oil supplements have been used safely for up to 6 months.
Large doses of 30 grams per day and higher can cause loose stools and diarrhea. Allergic reactions have occurred while taking flaxseed oil.
Some men worry that taking flaxseed oil might increase their chance of getting prostate cancer because of the alpha-linolenic acid that flaxseed oil contains. Researchers are still trying to figure out the role of alpha-linolenic acid in prostate cancer. Some studies suggest that alpha-linolenic acid may increase risk or make existing prostate cancer worse, but other studies find no connection. Nevertheless, the alpha-linolenic acid in flaxseed oil does not seem to be a problem. Alpha-linolenic acid from plant sources, such as flaxseed, does not seem to affect prostate cancer risk, although alpha-linolenic acid from dairy and meat sources has been linked in some studies with prostate cancer.
Flaxseed oil is POSSIBLY SAFE when applied to the skin in the short-term. Flaxseed oil has been used safely on the wrist for up to 4 weeks.
Special Precautions & Warnings:Children: Flaxseed is POSSIBLY SAFE for children when taken by mouth, short-term. Flaxseed oil has been safely taken by mouth for up to 3 months by children about 7-8 years old.
Pregnancy: Flaxseed oil is POSSIBLY UNSAFE when taken by mouth during pregnancy. Some research suggests that flaxseed oil might increase the chance of premature birth when taken during the second or third trimesters of pregnancy. However, other research suggests that taking flaxseed oil might be safe starting from the second or third trimester and continuing until delivery. Until more is known, pregnant women should avoid taking flaxseed oil.
Breast-feeding: There is not enough reliable information about the safety of taking flaxseed oil if you are breast feeding. Stay on the safe side and avoid use.
Bleeding disorders: Flaxseed oil might increase the risk of severe bleeding in patients with bleeding disorders. Talk to your healthcare provider before using flaxseed oil if you have a bleeding disorder.
Surgery: Flaxseed oil might increase the risk of bleeding during and after surgery. Stop using it at least 2 weeks before a scheduled surgery.
Medications that lower blood pressure (Antihypertensive drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Flaxseed oil might lower blood pressure. Combining flaxseed oil with other drugs that lower blood pressure might increase the chance of blood pressure going too low.
Some medications that lower blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Flaxseed oil might slow blood clotting and increase bleeding time. Taking flaxseed oil along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
The following doses have been studied in scientific research:
APPLIED TO THE SKIN:
- For carpal tunnel syndrome: 5 drops of flaxseed oil has been applied to the wrist twice daily for 4 weeks.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
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Cornish, S. M. and Chilibeck, P. D. Alpha-linolenic acid supplementation and resistance training in older adults. Appl.Physiol Nutr.Metab 2009;34(1):49-59. View abstract.
Gracious, B. L., Chirieac, M. C., Costescu, S., Finucane, T. L., Youngstrom, E. A., and Hibbeln, J. R. Randomized, placebo-controlled trial of flax oil in pediatric bipolar disorder. Bipolar.Disord. 2010;12(2):142-154. View abstract.
Oomen, C. M., Ocke, M. C., Feskens, E. J., Kok, F. J., and Kromhout, D. alpha-Linolenic acid intake is not beneficially associated with 10-y risk of coronary artery disease incidence: the Zutphen Elderly Study. Am J Clin Nutr. 2001;74(4):457-463. View abstract.
Rallidis, L. S., Paschos, G., Liakos, G. K., Velissaridou, A. H., Anastasiadis, G., and Zampelas, A. Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. Atherosclerosis 2003;167(2):237-242. View abstract.
Wilkinson, P., Leach, C., Ah-Sing, E. E., Hussain, N., Miller, G. J., Millward, D. J., and Griffin, B. A. Influence of alpha-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype. Atherosclerosis 2005;181(1):115-124. View abstract.
Allman MA, Pena MM, Pang D. Supplementation with flaxseed oil versus sunflower seed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur J Clin Nutr 1995;49:169-78. View abstract.
Allman, M. A., Pena, M. M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur.J Clin.Nutr. 1995;49(3):169-178. View abstract.
Alonso L, Marcos ML, Blanco JG, et al. Anaphylaxis caused by linseed (flaxseed) intake. J Allergy Clin Immunol 1996;98:469-70. View abstract.
Ascherio A, Rimm EB, Giovannucci EL, et al. Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. BMJ 1996;313:84-90. View abstract.
Barceló-Coblijn G, Murphy EJ, Othman R, et al. Flaxseed oil and fish-oil capsule consumption alters human red blood cell n-3 fatty acid composition: a multiple-dosing trial comparing 2 sources of n-3 fatty acid. Am J Clin Nutr 2008;88:801-9. View abstract.
Barden, A. E., Croft, K. D., Durand, T., Guy, A., Mueller, M. J., and Mori, T. A. Flaxseed oil supplementation increases plasma F1-phytoprostanes in healthy men. J Nutr 2009;139(10):1890-1895. View abstract.
Barre DE, Mizier-Barre KA, Griscti O, Hafez K. High dose flaxseed oil supplementation may affect fasting blood serum glucose management in human type 2 diabetics. J Oleo Sci 2008;57:269-73. View abstract.
Bierenbaum ML, Reichstein R, Watkins TR, and et al. Reducing atherogenic risk in hyperlipemic humans with flax seed supplementation: a preliminary report. J Am Coll Nutr. 1993;12:501-504.
Bloedon LT, Szapary PO. Flaxseed and cardiovascular risk. Nutr Rev 2004;62:18-27. View abstract.
Bougnoux, P., Koscielny, S., Chajes, V., Descamps, P., Couet, C., and Calais, G. alpha-Linolenic acid content of adipose breast tissue: a host determinant of the risk of early metastasis in breast cancer. Br.J Cancer 1994;70(2):330-334. View abstract.
Brouwer IA, Katan MB, Zock PL. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 2004;134:919-22. View abstract.
Chavarro JE, Stampfer MJ, Li H, et al. A prospective study of polyunsaturated fatty acid levels in blood and prostate cancer risk. Cancer Epidemiol Biomarkers Prev 2007;16:1364-70. View abstract.
Christensen JH, Christensen MS, Toft E, et al. Alpha-linolenic acid and heart rate variability. Nutr Metab Cardiovasc Dis 2000;10:57-61. View abstract.
Clandinin, M. T., Foxwell, A., Goh, Y. K., Layne, K., and Jumpsen, J. A. Omega-3 fatty acid intake results in a relationship between the fatty acid composition of LDL cholesterol ester and LDL cholesterol content in humans. Biochim.Biophys.Acta 6-23-1997;1346(3):247-252. View abstract.
Crawford M, Galli C, Visioli F, et al. Role of Plant-Derived Omega-3 Fatty Acids in Human Nutrition. Ann Nutr Metab 2000;44:263-5. View abstract.
Cunnane SC, Ganguli S, Menard C, et al. High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans. Br J Nutr 1993;69:443-53. View abstract.
Cunnane SC, Hamadeh MJ, Liede AC, et al. Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr 1995;61:62-8. View abstract.
de Deckere EAM, Korver O, Verschuren PM, Katan MB. Health aspects of fish and n-3 polyunsaturated fatty acids from plant and marine origin. Eur J Clin Nutr 1998;52:749-53. View abstract.
de Lorgeril M, Renaud S, Mamelle N, et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 1994;343:1454-9. View abstract.
De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Cancer Epidemiol Biomarkers Prev 2000;9:335-8. View abstract.
De, Spirt S., Stahl, W., Tronnier, H., Sies, H., Bejot, M., Maurette, J. M., and Heinrich, U. Intervention with flaxseed and borage oil supplements modulates skin condition in women. Br J Nutr 2009;101(3):440-445. View abstract.
Din JN, Newby DE, Flapan AD. Omega 3 fatty acids and cardiovascular disease--fishing for a natural treatment. BMJ 2004;328:30-5. View abstract.
Djousse L, Arnett DK, Carr JJ, et al. Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the National Heart, Lung, and Blood Institute Family Heart Study. Circulation 2005;111:2921-6. View abstract.
Djousse L, Arnett DK, Pankow JS, et al. Dietary linolenic acid is associated with a lower prevalence of hypertension in the NHLBI Family Heart Study. Hypertension 2005;45:368-73. View abstract.
Djousse L, Rautaharju PM, Hopkins PN, et al. Dietary linolenic acid and adjusted QT and JT intervals in the National Heart, Lung, and Blood Institute Family Heart study. J Am Coll Cardiol 2005;45:1716-22. View abstract.
Finnegan YE, Howarth D, Minihane AM, et al. Plant and marine derived (n-3) polyunsaturated fatty acids do not affect blood coagulation and fibrinolytic factors in moderately hyperlipidemic humans. J Nutr 2003;133:2210-3.. View abstract.
Finnegan YE, Minihane AM, Leigh-Firbank EC, et al. Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. Am J Clin Nutr 2003;77:783-95. View abstract.
Fischer S, Honigmann G, Hora C, et al. [Results of linseed oil and olive oil therapy in hyperlipoproteinemia patients]. Dtsch Z Verdau Stoffwechselkr 1984;44:245-51. View abstract.
Francois CA, Connor SL, Bolewicz LC, Connor WE. Supplementing lactating women with flaxseed oil does not increase docosahexaenoic acid in their milk. Am J Clin Nutr 2003;77:226-33. View abstract.
Freese R, Mutanen M. Alpha-linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. Am J Clin Nutr 1997;66:591-8. View abstract.
Fukumitsu, S., Aida, K., Shimizu, H., and Toyoda, K. Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men. Nutr Res 2010;30(7):441-446. View abstract.
Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. View abstract.
Giovannucci E, Rimm EB, Colditz GA, et al. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst 1993;85:1571-9. View abstract.
Goyal A, Sharma V, Upadhyay N, Gill S, Sihag M. Flax and flaxseed oil: an ancient medicine & modern functional food. J Food Sci Technol. 2014 Sep;51(9):1633-53. View abstract.
Harper CR, Edwards MC, Jacobson TA. Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. J Nutr 2006;136:2844-8. View abstract.
Harvei S, Bjerve KS, Tretli S, et al. Prediagnostic level of fatty acids in serum phospholipids: omega-3 and omega-6 fatty acids and the risk of prostate cancer. Int J Cancer 1997;71:545-51. View abstract.
Hashempur MH, Homayouni K, Ashraf A, Salehi A, Taghizadeh M, Heydari M. Effect of Linum usitatissimum L. (linseed) oil on mild and moderate carpal tunnel syndrome: a randomized, double-blind, placebo-controlled clinical trial. Daru. 2014;22:43. View abstract.
Hooper L, Thompson RL, Harrison RA, et al. Omega 3 fatty acids for prevention and treatment of cardiovascular disease. Cochrane Database Syst Rev 2004;(4):CD003177. View abstract.
Hu FB, Stampfer MJ, Manson JE, et al. Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women. Am J Clin Nutr 1999;69:890-7. View abstract.
Iso H, Sato S, Umemura U, et al. Linoleic acid, other fatty acids, and the risk of stroke. Stroke 2002;33:2086-93. View abstract.
Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiovascular disease risk in the canola oil multicenter randomized controlled trial. Am J Clin Nutr. 2014 Jul;100(1):88-97. View abstract.
Joshi K, Lad S, Kale M, et al. Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD). Prostaglandins Leukot Essent Fatty Acids 2006;74:17-21. View abstract.
Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. View abstract.
Kelley, D. S., Nelson, G. J., Love, J. E., Branch, L. B., Taylor, P. C., Schmidt, P. C., Mackey, B. E., and Iacono, J. M. Dietary alpha-linolenic acid alters tissue fatty acid composition, but not blood lipids, lipoproteins or coagulation status in humans. Lipids 1993;28(6):533-537. View abstract.
Klein V, Chajes V, Germain E, et al. Low alpha-linolenic acid content of adipose breast tissue is associated with an increased risk of breast cancer. Eur J Cancer 2000;36:335-40. View abstract.
Kolonel LN, Nomura AM, Cooney RV. Dietary fat and prostate cancer: current status. J Natl Cancer Inst 1999;91:414-28. View abstract.
Kris-Ehterton PM, Harris WS, Appel LJ, et al. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002;106:2747-57. View abstract.
Laaksonen DE, Laukkanen JA, Niskanen L, et al. Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Int J Cancer 2004;111:444-50.. View abstract.
Layne KS, Goh YK, Jumpsen JA, et al. Normal subjects consuming physiological levels of 18:3(n-3) and 20:5(n-3) from flaxseed or fish oils have characteristic differences in plasma lipid and lipoprotein fatty acid levels. J Nutr 1996;126:2130-40. View abstract.
Leitzmann MF, Stampfer MJ, Michaud DS, et al. Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. Am J Clin Nutr 2004;80:204-16. View abstract.
Lemos JR, Alencastro MG, Konrath AV, Cargnin M, Manfro RC. Flaxseed oil supplementation decreases C-reactive protein levels in chronic hemodialysis patients. Nutr Res. 2012 Dec;32(12):921-7. View abstract.
Mann J, Truswell AS, eds. Essentials of Human Nutrition. Oxford: Oxford Univ Press 1998.
Merchant AT, Curhan GC, Rimm EB, et al. Intake of n-6 and n-3 fatty acids and fish and risk of community-acquired pnemonia in US men. Am J Clin Nutr 2005;82:668-74. View abstract.
Mozaffarian D, Ascherio A, Hu FB, et al. Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men. Circulation 2005;111:157-64. View abstract.
Nelson, T. L., Hokanson, J. E., and Hickey, M. S. Omega-3 fatty acids and lipoprotein associated phospholipase A(2) in healthy older adult males and females. View abstract.
Nestel PJ, Pomeroy SE, Sasahara T, et al. Arterial compliance in obese subjects is improved with dietary plant n-3 fatty acid from flaxseed oil despite increased LDL oxidizability. Arterioscler Thromb Vasc Biol 1997;17:1163-70. View abstract.
Neukam, K., De, Spirt S., Stahl, W., Bejot, M., Maurette, J. M., Tronnier, H., and Heinrich, U. Supplementation of flaxseed oil diminishes skin sensitivity and improves skin barrier function and condition. Skin Pharmacol Physiol 2011;24(2):67-74. View abstract.
Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. View abstract.
Pan A, Yu D, Demark-Wahnefried W, et al. Meta-analysis of the effects of flaxseed interventions on blood lipids. Am J Clin Nutr 2009;90:288-97. View abstract.
Pang D, Allman-Farinelli MA, Wong T, et al. Replacement of linoleic acid with alpha-linolenic acid does not alter blood lipids in normolipidaemic men. Br J Nutr 1998;80:163-7. View abstract.
Paschos GK, Magkos F, Panagiotakos DB, et al. Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. Eur J Clin Nutr 2007;61:1201-6. View abstract.
Pinheiro MN Jr, dos Santos PM, dos Santos RC, et al. [Oral flaxseed oil (Linum usitatissimum) in the treatment for dry-eye Sjögren's syndrome patients]. Arq Bras Oftalmol 2007;70:649-55. View abstract.
Prasad K. Dietary flax seed in prevention of hypercholesterolemic atherosclerosis. Atherosclerosis 1997;132:69-76. View abstract.
Ramon JM, Bou R, Romea S, et al. Dietary fat intake and prostate cancer risk: a case-control study in Spain. Cancer Causes Control 2000;11:679-85. View abstract.
Singer, P., Jaeger, W., Berger, I., Barleben, H., Wirth, M., Richter-Heinrich, E., Voigt, S., and Godicke, W. Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension. J Hum Hypertens. 1990;4(3):227-233. View abstract.
Suttmann, U., Ockenga, J., Schneider, H., Selberg, O., Schlesinger, A., Gallati, H., Wolfram, G., Deicher, H., and Muller, M. J. Weight gain and increased concentrations of receptor proteins for tumor necrosis factor after patients with symptomatic HIV infection received fortified nutrition support. J Am Diet.Assoc 1996;96(6):565-569. View abstract.
Tarpila, S., Aro, A., Salminen, I., Tarpila, A., Kleemola, P., Akkila, J., and Adlercreutz, H. The effect of flaxseed supplementation in processed foods on serum fatty acids and enterolactone. Eur.J Clin Nutr 2002;56(2):157-165. View abstract.
Taylor, C. G., Noto, A. D., Stringer, D. M., Froese, S., and Malcolmson, L. Dietary milled flaxseed and flaxseed oil improve N-3 fatty acid status and do not affect glycemic control in individuals with well-controlled type 2 diabetes. J Am Coll Nutr 2010;29(1):72-80. View abstract.
Thompson LU, Rickard SE, Orcheson LJ, Seidl MM. Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesis. Carcinogenesis 1996;17:1373-6. View abstract.
University of Montreal. Pregnant Women Consuming Flaxseed Oil Have High Risk Of Premature Birth.ScienceDaily, October 29, 2008. Available at: www.sciencedaily.com/releases/2008/10/081027140817.htm (Accessed May 14, 2009).
Vargas, M. L., Almario, R. U., Buchan, W., Kim, K., and Karakas, S. E. Metabolic and endocrine effects of long-chain versus essential omega-3 polyunsaturated fatty acids in polycystic ovary syndrome. Metabolism 2011;60(12):1711-1718. View abstract.
West, S. G., Krick, A. L., Klein, L. C., Zhao, G., Wojtowicz, T. F., McGuiness, M., Bagshaw, D. M., Wagner, P., Ceballos, R. M., Holub, B. J., and Kris-Etherton, P. M. Effects of diets high in walnuts and flax oil on hemodynamic responses to stress and vascular endothelial function. J Am Coll.Nutr 2010;29(6):595-603. View abstract.
Wojtowicz JC, Butovich I, Uchiyama E, et al. Pilot, prospective, randomized, double-masked, placebo-controlled clinical trial of an omega-3 supplement for dry eye. Cornea 2010 Oct 28. [Epub ahead of print]. View abstract.