Medical Editor: John P. Cunha, DO, FACOEP
Florinef (fludrocortisone) Acetate is a steroid used to treat conditions in which the body does not produce enough of its own steroids, such as Addison's disease, and salt-losing adrenogenital syndrome. The brand name Florinef is discontinued in the U.S. Florinef is available in generic form. Common side effects of Florinef include:
- stomach upset or pain,
- spinning sensation,
- sleep problems (insomnia),
- mood changes,
- dry skin,
- thinning skin,
- bruising or discoloration,
- slow wound healing,
- increased sweating,
- changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist), and
- menstrual changes (e.g., delayed/irregular/absent periods).
Tell your doctor if you have unlikely but serious side effects of Florinef including:
- easy bleeding,
- signs of infection (e.g., fever, persistent sore throat, skin sores),
- bone/joint/muscle pain,
- puffy face,
- swelling of the hands or feet,
- severe tiredness,
- increased thirst or urination,
- unusual weight gain, or
- muscle weakness.
Dosage of fludrocortisone depends on the severity of the disease and patient's response. To treat Addison's disease, the usual dose is 0.1 mg daily. The recommended dosage for treating the salt-losing adrenogenital syndrome is 0.1 mg to 0.2 mg daily. Fludrocortisone may interact with aspirin, amphotericin B, diuretics (water pills), digoxin, phenytoin, rifampin, birth control pills or hormone replacement therapy, blood thinners, insulin or oral diabetes medications, steroids, or barbiturates. Tell your doctor all medications you use. During pregnancy, fludrocortisone should be used only when prescribed. Infants born to mothers who have used this medication may have low levels of corticosteroid hormone. Tell your doctor if you notice persistent nausea/vomiting, severe diarrhea, or weakness in your newborn. This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.
Our Florinef (fludrocortisone) Acetate Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- problems with your vision;
- swelling, rapid weight gain, feeling short of breath;
- severe depression, unusual thoughts or behavior, seizure (convulsions);
- bloody or tarry stools, coughing up blood;
- pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate);
- low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling); or
- dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).
Less serious side effects may include:
- sleep problems (insomnia), mood changes;
- acne, dry skin, thinning skin, bruising or discoloration;
- slow wound healing;
- increased sweating;
- headache, dizziness, spinning sensation;
- nausea, stomach pain, bloating; or
- changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Florinef (Fludrocortisone)
Most adverse reactions are caused by the drug's mineralocorticoid activity (retention of sodium and water) and include hypertension, edema, cardiac enlargement, congestive heart failure, potassium loss, and hypokalemic alkalosis.
When fludrocortisone is used in the small dosages recommended, the glucocorticoid side effects often seen with cortisone and its derivatives are not usually a problem; however the following untoward effects should be kept in mind, particularly when fludrocortisone is used over a prolonged period of time or in conjunction with cortisone or a similar glucocorticoid.
Musculoskeletal-muscle weakness, steroid myopathy, loss of muscle mass, osteoporosis, vertebral compression fractures, aseptic necrosis of femoral and humeral heads, pathologic fracture of long bones, and spontaneous fractures.
Dermatologic-impaired wound healing, thin fragile skin, bruising, petechiae and ecchymoses, facial erythema, increased sweating, subcutaneous fat atrophy, purpura, striae, hyperpigmentation of the skin and nails, hirsutism, acneiform eruptions, and hives; reactions to skin tests may be suppressed.
Endocrine-menstrual irregularities; development of the cushingoid state; suppression of growth in children; secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress (e.g., trauma, surgery, or illness); decreased carbohydrate tolerance; manifestations of latent diabetes mellitus; and increased requirements for insulin or oral hypoglycemic agents in diabetics.
Metabolic-hyperglycemia, glycosuria, and negative nitrogen balance due to protein catabolism.
Allergic Reactions-allergic skin rash, maculopapular rash, and urticaria.
Other adverse reactions that may occur following the administration of a corticosteroid are necrotizing angiitis, thrombophlebitis, aggravation or masking of infections, insomnia, syncopal episodes, and anaphylactoid reactions.
Read the entire FDA prescribing information for Florinef (Fludrocortisone)
© Florinef Patient Information is supplied by Cerner Multum, Inc. and Florinef Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.