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Last reviewed on RxList: 11/29/2016
Floxuridine Side Effects Center

Last reviewed on RxList 5/26/2016

Floxuridine for Injection is a cancer (antineoplastic) medication used in the treatment of digestive system cancers that have spread to the liver. Floxuridine is available in generic form. Common side effects of floxuridine include:

  • nausea and vomiting (may be severe)
  • abdominal pain
  • mild diarrhea
  • loss of appetite
  • weight loss
  • tiredness
  • redness at the injection site reactions (redness, pain, itching, swelling, bleeding blisters, or sores)
  • dry skin
  • redness of the palms of the hands or soles of the feet
  • watery eyes
  • balance problems
  • confusion
  • rash and itching, or
  • temporary hair loss

The recommended therapeutic dosage schedule of floxuridine by continuous arterial infusion is 0.1 to 0.6 mg/kg/day. Floxuridine may interact with "live" vaccines. Tell your doctor all medications and supplements you use and all vaccines you recently received. Floxuridine is not recommended for use during pregnancy. It may harm a fetus. Consult your doctor to discuss birth control. It is recommended that men and women use 2 forms of birth control (e.g., condoms, birth control pills) while using this medication. It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breastfeeding while using floxuridine is not recommended.

Our Floxuridine for Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Floxuridine Consumer Information

If you experience any of the following serious side effects from floxuridine, contact your doctor immediately:

  • an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection);
  • severe vomiting;
  • diarrhea, frequent bowel movements or watery stools; or
  • sores in the mouth or throat; or
  • stomach pain or heartburn or black, bloody or tarry stools.

Other, less serious side effects may be more likely to occur. Continue taking floxuridine and talk to your doctor if you experience:

  • mild to moderate nausea, vomiting or loss of appetite;
  • redness of the palms of the hands or soles of the feet;
  • increased eye watering;
  • balance problems;
  • confusion;
  • rash and itching; or
  • temporary hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Floxuridine (Floxuridine)

Floxuridine Professional Information


Adverse reactions to the arterial infusion of floxuridine are generally related to the procedural complications of regional arterial infusion.

The more common adverse reactions to the drug are nausea, vomiting, diarrhea, enteritis, stomatitis and localized erythema. The more common laboratory abnormalities are anemia, leukopenia, thrombocytopenia and elevations of alkaline phosphatase, serum transaminase, serum bilirubin and lactic dehydrogenase.

Other adverse reactions are:

Gastrointestinal: duodenal ulcer, duodenitis, gastritis, bleeding, gastroenteritis, glossitis, pharyngitis, anorexia, cramps, abdominal pain; possible intra- and extrahepatic biliary sclerosis, as well as acalculous cholecystitis.

Dermatologic: alopecia, dermatitis, nonspecific skin toxicity, rash.

Cardiovascular: myocardial ischemia.

Miscellaneous Clinical Reactions: fever, lethargy, malaise, weakness.

Laboratory Abnormalities: BSP, prothrombin, total proteins, sedimentation rate and thrombopenia.

Procedural Complications of Regional Arterial Infusion: arterial aneurysm; arterial ischemia; arterial thrombosis; embolism; fibromyositis; thrombophlebitis; hepatic necrosis; abscesses; infection at catheter site; bleeding at catheter site; catheter blocked, displaced or leaking.

The following adverse reactions have not been reported with floxuridine but have been noted following the administration of 5-fluorouracil. While the possibility of these occurring following floxuridine therapy is remote because of its regional administration, one should be alert for these reactions following the administration of floxuridine because of the pharmacological similarity of these two drugs: pancytopenia, agranulocytosis, myocardial ischemia, angina, anaphylaxis, generalized allergic reactions, acute cerebellar syndrome, nystagmus, headache, dry skin, fissuring, photosensitivity, pruritic maculopapular rash, increased pigmentation of the skin, vein pigmentation, lacrimal duct stenosis, visual changes, lacrimation, photophobia, disorientation, confusion, euphoria, epistaxis and nail changes, including loss of nails.

Read the entire FDA prescribing information for Floxuridine (Floxuridine)

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© Floxuridine Patient Information is supplied by Cerner Multum, Inc. and Floxuridine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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