Fludrocortisone vs. Hydrocortisone

Are Fludrocortisone and Hydrocortisone the Same Thing?

Fludrocortisone acetate tablets and hydrocortisone cream are corticosteroids used to treat different conditions.

Fludrocortisone is used as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.

Hydrocortisone cream is a topical (for the skin) medication used to treat inflammation of the skin caused by a number of conditions such as allergic reactions, eczema, or psoriasis.

What Are Possible Side Effects of Fludrocortisone?

Common side effects of Fludrocortisone include:

What Are Possible Side Effects of Hydrocortisone?

Common side effects of Hydrocortisone include:

  • skin redness/burning/itching/peeling,
  • thinning of your skin,
  • blistering skin,
  • stretch marks,
  • nausea,
  • heartburn,
  • headache,
  • dizziness,
  • menstrual period changes,
  • trouble sleeping (insomnia),
  • increased sweating, or
  • acne.

Tell your doctor if you have any serious side effects of Hydrocortisone Cream including blurred vision, or seeing halos around lights, uneven heartbeats, weight gain, puffiness in your face, or feeling tired.

What Is Fludrocortisone?

Fludrocortisone acetate tablets are an adrenocortical steroid indicated as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.

What Is Hydrocortisone?

Hydrocortisone (hydrocortisone) Cream 2.5% is a topical (for the skin) steroid used to treat inflammation of the skin caused by a number of conditions such as allergic reactions, eczema, or psoriasis.

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What Drugs Interact With Fludrocortisone?

Fludrocortisone may interact with amphotericin B, potassium-depleting diuretics, digitalis glycosides, oral anticoagulants, antidiabetic drugs (oral agents and insulin), aspirin, barbiturates, phenytoin, rifampin, anabolic steroids, vaccines, and estrogen.

What Drugs Interact With Hydrocortisone?

It is not likely other drugs you take orally or inject will have an effect on topically applied hydrocortisone. But many drugs can interact with each other. Tell your doctor all prescription and over-the-counter medications and supplements you use. During pregnancy, hydrocortisone should be used only when prescribed. Infants born to mothers who have been using this medication for an extended period of time may have hormone problems.

How Should Fludrocortisone Be Taken?

Dosage of fludrocortisone depends on the severity of the disease and the response of the patient. The usual dose is 0.1 mg of fludrocortisone acetate daily.

How Should Hydrocortisone Be Taken?

Dose and administration: Apply hydrocortisone cream to the affected area as a thin film 2 to 4 times daily depending on the severity of the condition.

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References

DailyMed. Hydrocortisone Product Information.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5f6acc2b-7a6e-7f98-e053-2991aa0a46e7
DailyMed. Fludrocortisone Product Information.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4ed382df-f2d5-46a4-a68b-aba807777093

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