Last updated on RxList: 1/11/2021
Fluoroplex Side Effects Center

What is Fluoroplex?

Fluoroplex (fluorouracil topical cream) is an antineoplastic/antimetabolite product that works by blocking the growth of abnormal cells that cause the skin condition used to treat scaly overgrowths of skin (actinic or solar keratoses), or in the treatment of superficial basal cell carcinoma.

What are side effects of Fluoroplex?

Common side effects of Fluoroplex include:

  • skin irritation,
  • burning,
  • redness,
  • dryness,
  • scaling,
  • peeling (exfoliation),
  • pain,
  • swelling,
  • tenderness,
  • rash, or
  • changes in skin color at the site of application

Other side effects of Fluoroplex include eye irritation (stinging, watering), trouble sleeping, irritability, temporary hair loss, or abnormal taste in the mouth.

Dosage for Fluoroplex

Apply a sufficient dose of Fluoroplex to cover the entire face or other affected areas. Apply medication twice daily with fingertips and wash hands afterwards. Treatment for 2-6 weeks is usually required.

What Drugs, Substances, or Supplements Interact with Fluoroplex?

Fluoroplex may interact with other prescription or over-the-counter skin products. Do not use these products unless directed by your doctor. Tell your doctor all medications and supplements you use.

Fluoroplex During Pregnancy and Breastfeeding

Fluoroplex must not be used during pregnancy. It may harm a fetus. If you become pregnant or think you may be pregnant, inform your doctor. Consult your doctor about birth control. It is unknown if this medication passes into breast milk. Due to the potential risk to a nursing infant, breastfeeding is not recommended while using this drug.

Additional Information

Our Fluoroplex (fluorouracil topical cream) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Fluoroplex Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using fluorouracil topical and call your doctor at once if you have:

  • severe pain or swelling of treated skin;
  • severe itching, burning, or irritation;
  • new or worsening skin sores;
  • fever, chills; or
  • severe stomach pain, bloody diarrhea, vomiting.

Before your skin begins to heal it will become red, dry, tender, and crusty. This is a normal skin reaction, even if these symptoms get worse for a short time. Gradually, the dead skin will begin to shed off and you'll see raw skin appear. Ask your doctor when to stop using the medicine after you notice signs of healing.

Common side effects may include:

  • skin pain, itching, burning, or irritation;
  • skin darkening or scarring;
  • skin redness and swelling; or
  • small blood vessels under the skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Fluoroplex (Fluorouracil Topical Cream)


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Fluoroplex Professional Information


Pain, pruritus, burning, irritation, inflammation, allergic contact dermatitis and telangiectasia have been reported. Occasionally, hyperpigmentation and scarring have also been reported.

Read the entire FDA prescribing information for Fluoroplex (Fluorouracil Topical Cream)

© Fluoroplex Patient Information is supplied by Cerner Multum, Inc. and Fluoroplex Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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