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Last reviewed on RxList: 1/9/2017
Fluoroplex Side Effects Center

Last reviewed on RxList 11/20/2015

Fluoroplex (fluorouracil topical cream) is an antineoplastic/antimetabolite product that works by blocking the growth of abnormal cells that cause the skin condition used to treat scaly overgrowths of skin (actinic or solar keratoses), or in the treatment of superficial basal cell carcinoma. Common side effects of Fluoroplex include skin irritation, burning, redness, dryness, scaling, peeling (exfoliation), pain, swelling, tenderness, rash, or changes in skin color at the site of application. Other side effects of Fluoroplex include eye irritation (stinging, watering), trouble sleeping, irritability, temporary hair loss, or abnormal taste in the mouth.

Apply a sufficient dose of Fluoroplex to cover the entire face or other affected areas. Apply medication twice daily with fingertips and wash hands afterwards. Treatment for 2-6 weeks is usually required. Fluoroplex may interact with other prescription or over-the-counter skin products. Do not use these products unless directed by your doctor. Tell your doctor all medications and supplements you use. Fluoroplex must not be used during pregnancy. It may harm a fetus. If you become pregnant or think you may be pregnant, inform your doctor. Consult your doctor about birth control. It is unknown if this medication passes into breast milk. Due to the potential risk to a nursing infant, breastfeeding is not recommended while using this drug.

Our Fluoroplex (fluorouracil topical cream) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Fluoroplex Consumer Information

Serious side effects are not likely to occur. Stop using fluorouracil topical and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).

Fluorouracil topical may cause skin irritation, dryness, scaling or peeling (exfoliation), rash, and other local reactions. Eye irritation has also been reported. If these side effects are excessive or worsen with continued treatment, contact your doctor.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Fluoroplex (Fluorouracil Topical Cream)

Fluoroplex Professional Information


Pain, pruritus, burning, irritation, inflammation, allergic contact dermatitis and telangiectasia have been reported. Occasionally, hyperpigmentation and scarring have also been reported.

Read the entire FDA prescribing information for Fluoroplex (Fluorouracil Topical Cream)

Related Resources for Fluoroplex

Read the Fluoroplex User Reviews »

© Fluoroplex Patient Information is supplied by Cerner Multum, Inc. and Fluoroplex Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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