Reviewed on 7/7/2022

What Is Flutamide and How Does It Work?

Flutamide is a prescription medication used for the treatment of prostate cancer

  • Flutamide is available under the following different brand names: Eulexin 

What Are Dosages of Flutamide?

Adult  dosage


  • 125 mg

Prostate Cancer

Adult dosage

  • 250 mg orally every 8 hours

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”

What Are Side Effects Associated with Using Flutamide?

Common side effects of Flutamide include:

  • breast swelling or tenderness,
  • hot flashes,
  • vomiting,
  • nausea,
  • diarrhea,
  • impotence, and
  • loss of interest in sex.

Serious side effects of Flutamide include:

  • hives,
  • difficulty breathing,
  • swelling of the face, lips, tongue, or throat,
  • nausea,
  • upper stomach pain,
  • loss of appetite,
  • itching,
  • tiredness,
  • flu-like symptoms,
  • dark urine,
  • clay-colored stools, and
  • yellowing of the skin or eyes (jaundice)

Rare side effects of Flutamide include:

  • none

Seek medical care or call 911 at once if you have the following serious side effects:

  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheartedness, or passing out.
This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

What Other Drugs Interact with Flutamide?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Flutamide has severe interactions with no other drugs.
  • Flutamide has serious interactions with the following drugs:
  • Flutamide has moderate interactions with at least 21 other drugs.
  • Flutamide has minor interactions with the following drugs:

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

What Are Warnings and Precautions for Flutamide?


  • Hypersensitivity, severe hepatic disease

Effects of drug abuse

  • None

Short-Term Effects

  • See “What Are Side Effects Associated with Using Flutamide?”

Long-Term Effects

  • See “What Are Side Effects Associated with Using Flutamide?”


Pregnancy & Lactation

  • Use in LIFE-THREATENING emergencies when no safer drug is available
  • Lactation
    • Excretion in milk unknown; not recommended

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