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Fosamax vs. Evista

Medical and Pharmacy Editor:

Are Fosamax and Evista the Same Thing?

Fosamax (alendronate sodium) and Evista (teriparatide [rDNA origin]) are used to treat and prevent osteoporosis.

Fosamax is also used to treat Paget's disease.

Fosamax and Evista belong to different drug classes. Fosamax is a bisphosphonate and Evista is a synthetic parathyroid hormone.

What Are Possible Side Effects of Fosamax?

Common side effects of Fosamax include:

  • gas,
  • constipation,
  • heartburn,
  • diarrhea,
  • bloating,
  • nausea,
  • vomiting,
  • stomach pain,
  • joint pain or swelling,
  • swelling in your hands or feet,
  • dizziness,
  • headache,
  • eye pain,
  • back pain, or
  • weakness.

Serious side effects of Fosamax include:

  • severe pain (joints, bone, muscle, jaw, back or heartburn),
  • chest pain,
  • difficulty swallowing,
  • bloody stools,
  • eye pain,
  • skin blisters, and
  • swelling of the face, tongue, or throat.

What Are Possible Side Effects of Evista?

Common side effects of Evista include:

  • hot flashes,
  • increased sweating,
  • headache,
  • dizziness,
  • spinning sensation,
  • leg cramps or leg pain,
  • joint pain,
  • nausea,
  • vomiting,
  • stomach pain, or
  • runny or stuffy nose.
  • Evista may infrequently cause stroke or serious blood clots to form in the legs, lungs, or eyes.

Seek medical attention if you have unlikely but serious side effects of Evista including:

  • leg swelling or pain,
  • trouble breathing,
  • chest pain,
  • sudden vision changes,
  • severe headache,
  • weakness on one side of the body, or
  • confusion.

What is Fosamax?

Fosamax (alendronate sodium) is a bisphosphonate that is a specific inhibitor of osteoclast-mediated bone resorption used to both treat and prevent osteoporosis, and to treat Paget's disease.

What is Evista?

Evista (raloxifene hydrochloride) is an estrogen agonist/antagonist used to treat or prevent osteoporosis in postmenopausal women. Evista is also used to reduce the risk of invasive breast cancer in postmenopausal women who have osteoporosis or who are otherwise at risk of invasive breast cancer.

What Drugs Interact With Fosamax?

Fosamax may interact with aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs).

What Drugs Interact With Evista?

Evista may interact with cholestyramine, blood thinners, diazepam, diazoxide, birth control pills or hormone replacement therapy.

How Should Fosamax Be Taken?

Fosamax is available in a tablet or oral liquid form. Each bottle of the oral solution contains 91.35 mg of alendronate monosodium salt trihydrate, which is the molar equivalent to 70 mg of the drug. The recommended initial dosage is one 70 mg molar equivalent tablet or oral liquid bottle once weekly or one 10 mg molar equivalent tablet per day. Fosamax must be taken at least one-half hour before the first food, beverage, or medication of the day with plain water only to avoid any reduction in gastrointestinal adsorption.

How Should Evista Be Taken?

The recommended dosage is one 60 mg Evista tablet daily, taken any time of day without regard to meals.

Reviewed on 7/9/2018

Medical Editor: John P. Cunha, DO, FACOEP SOURCE:

FDA. Fosamax Medication Guide.

https://www.fda.gov/downloads/Drugs/DrugSafety/UCM241519.pdf

FDA. Evista Medication Guide.

https://www.fda.gov/downloads/Drugs/DrugSafety/ucm088593.pdf

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