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Fosamax vs. Prolia

Are Fosamax and Prolia the Same Thing?

Fosamax (alendronate sodium) and Prolia (denosumab) are used to treat and prevent osteoporosis.

Fosamax is also used to treat Paget's disease.

Fosamax and Prolia belong to different drug classes. Fosamax is a bisphosphonate and Prolia is a monoclonal antibody.

What Are Possible Side Effects of Fosamax?

Common side effects of Fosamax include:

Serious side effects of Fosamax include:

What Are Possible Side Effects of Prolia?

Common side effects of Prolia include:

You may also be more likely to get a serious infection, such as a skin, ear, stomach/gut, or bladder infection while taking Prolia. Tell your doctor if you develop signs of infection, such as:

Tell your doctor if your experience serious side effects of Prolia including jaw pain, new or unusual thigh/hip/groin pain, or bone/joint/muscle pain.

What is Fosamax?

Fosamax (alendronate sodium) is a bisphosphonate that is a specific inhibitor of osteoclast-mediated bone resorption used to both treat and prevent osteoporosis, and to treat Paget's disease.

What is Prolia?

Prolia (denosumab) is a monoclonal antibody used to treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause.

SLIDESHOW

Osteoporosis Super-Foods for Strong Bones With Pictures See Slideshow

What Drugs Interact With Fosamax?

Fosamax may interact with aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs).

What Drugs Interact With Prolia?

Prolia may interact with steroids or cancer medicine, cyclosporine, sirolimus, tacrolimus, basiliximab, muromonab-CD3, mycophenolate mofetil, azathioprine, leflunomide, or etanercept.

How Should Fosamax Be Taken?

Fosamax is available in a tablet or oral liquid form. Each bottle of the oral solution contains 91.35 mg of alendronate monosodium salt trihydrate, which is the molar equivalent to 70 mg of the drug. The recommended initial dosage is one 70 mg molar equivalent tablet or oral liquid bottle once weekly or one 10 mg molar equivalent tablet per day. Fosamax must be taken at least one-half hour before the first food, beverage, or medication of the day with plain water only to avoid any reduction in gastrointestinal adsorption.

How Should Prolia Be Taken?

Prolia should be administered by a doctor. The recommended dose of Prolia is 60 mg administered as a single subcutaneous (under the skin) injection once every 6 months.

QUESTION

What is another medical term for osteoporosis? See Answer
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References
Medical Editor: John P. Cunha, DO, FACOEP SOURCE:

FDA. Fosamax Medication Guide.

https://www.fda.gov/downloads/Drugs/DrugSafety/UCM241519.pdf

Amgen. Prolia Product Information.

https://pi.amgen.com/~/media/amgen/repositorysites/pi-amgen-com/prolia/prolia_pi.ashx

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