Furosemide

Last updated on RxList: 10/29/2020
Furosemide Side Effects Center

What is Furosemide?

Furosemide is a diuretic which is an anthranilic acid derivative used to treat edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Furosemide is particularly useful when an agent with greater diuretic potential is desired. Furosemide is also indicated as adjunctive therapy in acute pulmonary edema.

What are the possible side effects of Furosemide?

Furosemide may cause serious side effects including:

Dosage for Furosemide

The usual initial dose of furosemide is 20 to 40 mg given as a single dose, injected intramuscularly or intravenously.

Furosemide In Children

Renal calcifications (from barely visible on x-ray to staghorn) have occurred in some severely premature infants treated with intravenous furosemide for edema due to patent ductus arteriosus and hyaline membrane disease. The concurrent use of chlorothiazide has been reported to decrease hypercalcinuria and dissolve some calculi.

In premature infants furosemide may precipitate nephrocalcinosis/nephrolithiasis. Nephrocalcinosis/nephrolithiasis has also been observed in children under 4 years of age with no history of prematurity who have been treated chronically with furosemide. Monitor renal function, and renal ultrasonography should be considered, in pediatric patients receiving furosemide.

If furosemide is administered to premature infants during the first weeks of life, it may increase the risk of persistence of patent ductus arteriosus.

What Drugs, Substances, or Supplements Interact with Furosemide?

Furosemide may interact with other medicines such as:

Tell your doctor all medications and supplements you use.

Furosemide During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using furosemide; it may harm a fetus. Furosemide passes into breast milk and may also inhibit lactation. Caution should be exercised when furosemide is administered to a nursing mother. Consult your doctor before breastfeeding.

Aditional Information

Our Furosemide Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer
Furosemide Consumer Information

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • ringing in your ears, hearing loss;
  • muscle spasms or contractions;
  • pale skin, easy bruising, unusual bleeding;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;
  • kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
  • signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, dark urine, jaundice (yellowing of the skin or eyes); or
  • signs of an electrolyte imbalance--dry mouth, thirst, weakness, drowsiness, feeling jittery or unsteady, vomiting, irregular heartbeats, fluttering in your chest, numbness or tingling, muscle cramps, muscle weakness or limp feeling.

Common side effects may include:

  • diarrhea, constipation, loss of appetite;
  • numbness or tingling;
  • headache, dizziness; or
  • blurred vision.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Furosemide (Furosemide Tablets)

SLIDESHOW

Heart Disease: Symptoms, Signs, and Causes See Slideshow
Furosemide Professional Information

SIDE EFFECTS

Adverse reactions are categorized below by organ system and listed by decreasing severity.

Gastrointestinal System Reactions

  1. hepatic encephalopathy in patients with hepato-cellular insufficiency
  2. pancreatitis
  3. jaundice (intrahepatic cholestatic jaundice)
  4. increased liver enzymes
  5. anorexia
  6. oral and gastric irritation
  7. cramping
  8. diarrhea
  9. constipation
  10. nausea
  11. vomiting

Systemic Hypersensitivity Reactions

  1. Severe anaphylactic or anaphylactoid reactions (e.g. with shock)
  2. systemic vasculitis
  3. interstitial nephritis
  4. necrotizing angiitis

Central Nervous System Reactions

  1. tinnitus and hearing loss
  2. paresthesias
  3. vertigo
  4. dizziness
  5. headache
  6. blurred vision
  7. xanthopsia

Hematologic Reactions

  1. aplastic anemia
  2. thrombocytopenia
  3. agranulocytosis
  4. hemolytic anemia
  5. leukopenia
  6. anemia
  7. eosinophilia

Dermatologic-Hypersensitivity Reactions

  1. toxic epidermal necrolysis
  2. Stevens-Johnson Syndrome
  3. erythema multiforme
  4. drug rash with eosinophilia and systemic symptoms
  5. acute generalized exanthematous pustulosis
  6. exfoliative dermatitis
  7. bullous pemphigoid
  8. purpura
  9. photosensitivity
  10. rash
  11. pruritis
  12. urticaria

Cardiovascular Reaction

  • Orthostatic hypotension may occur and be aggravated by alcohol, barbiturates or narcotics.
  • Increase in cholesterol and triglyceride serum levels

Other Reactions

  • hyperglycemia
  • glycosuria
  • hyperuricemia
  • muscle spasm
  • weakness
  • restlessness
  • urinary bladder spasm
  • thrombophlebitis
  • fever

Whenever adverse reactions are moderate or severe, Furosemide tablets dosage should be reduced or therapy withdrawn.

CALL YOUR DOCTOR FOR MEDICAL ADVICE ABOUT SIDE EFFECTS. YOU MAY REPORT SIDE EFFECTS TO THE FDA AT 1-800-FDA-1088 OR LEADING PHARMA, LLC AT 1-844-740-7500.

Read the entire FDA prescribing information for Furosemide (Furosemide Tablets)

© Furosemide Patient Information is supplied by Cerner Multum, Inc. and Furosemide Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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