Gantrisin Side Effects Center

Last updated on RxList: 9/16/2008
Gantrisin Side Effects Center

Last reviewed on RxList 3/28/2016

Gantrisin (acetyl sulfisoxazole pediatric suspension) is a sulfonamide ("sulfa") antibiotic used to treat or prevent many different types of infections caused by bacteria, such as bladder infections, ear infections, or meningitis. The brand name Gantrisin is discontinued, but generic versions may be available. Common side effects of Gantrisin (acetyl sulfisoxazole pediatric suspension) include:

  •  stomach pain
  • bloating
  • gas
  • headache
  • dizziness
  • ringing in your ears, or
  • swollen, black, or "hairy" tongue

The initial dose of Gantrisin for pediatric patients over 2 months of age is one half of the 24-hour dose. Maintenance dose: 150 mg/kg/24 hours or 4 gm/M²/24 hours - dose to be divided into 4 to 6 doses/24 hours. Gantrisin may interact with blood thinners, methotrexate, or diabetes medications. Tell your doctor all medications and supplements you use. It is unknown if Gantrisin will harm a fetus. Gantrisin can cause jaundice (yellowing of the skin or eyes) and other problems in a newborn if the mother has taken this medication late in pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. This drug can pass into breast milk and may harm a nursing baby. Do not breastfeed while you are taking Gantrisin, especially if your baby is younger than 2 months old.

Our Gantrisin (acetyl sulfisoxazole pediatric suspension) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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The listing that follows includes adverse reactions both that have been reported with Gantrisin (acetyl sulfisoxazole pediatric suspension) and some which have not been reported with this specific drug; however, the pharmacologic similarities among the sulfonamides require that each of the reactions be considered with the administration of Gantrisin (acetyl sulfisoxazole pediatric suspension) .

Allergic/Dermatologic: Anaphylaxis, erythema multiforme (Stevens-Johnson syndrome), toxic epidermal necrolysis, exfoliative dermatitis, angioedema, arteritis and vasculitis, allergic myocarditis, serum sickness, rash, urticaria, pruritus, photosensitivity, and conjunctival and scleral injection, generalized allergic reactions and generalized skin eruptions. In addition, periarteritis nodosa and systemic lupus erythematosus have been reported (see WARNINGS).

Cardiovascular: Tachycardia, palpitations, syncope, cyanosis.

Endocrine: The sulfonamides bear certain chemical similarities to some goitrogens, diuretics (acetazolamide and thiazides) and oral hypoglycemia agents. Cross-sensitivity may exist with these agents. Development of goiter, diuresis and hypoglycemia have occurred rarely in patients receiving sulfonamides.

Gastrointestinal: Hepatitis, hepatocellular necrosis, jaundice, pseudomembranous colitis, nausea, emesis, anorexia, abdominal pain, diarrhea, gastrointestinal hemorrhage, melena, flatulence, glossitis, stomatitis, salivary gland enlargement, pancreatitis.

Onset of pseudomembranous colitis symptoms may occur during or after treatment with sulfisoxazole (see WARNINGS).

Sulfisoxazole has been reported to cause increased elevations of liver-associated enzymes in patients with hepatitis.

Genitourinary: Crystalluria, hematuria, BUN and creatinine elevations, nephritis and toxic nephrosis with oliguria and anuria. Acute renal failure and urinary retention have also been reported. The frequency of renal complications, commonly associated with some sulfonamides, is lower in patients receiving the more soluble sulfonamides such as sulfisoxazole.

Hematologic: Leukopenia, agranulocytosis, aplastic anemia, thrombocytopenia, purpura, hemolyticanemia, anemia, eosinophilia, clotting disorders including hypoprothrombinemia, and hypofibrinogenemia, sulfhemoglobinemia, methemoglobinemia.

Musculoskeletal: Arthralgia, myalgia.

Neurologic: Headache, dizziness, peripheral neuritis, paresthesia, convulsions, tinnitus, vertigo, ataxia, intracranial hypertension.

Psychiatric: Psychosis, hallucination, disorientation, depression, anxiety, apathy.

Respiratory: Cough, shortness of breath, pulmonary infiltrates (see WARNINGS).

Vascular: Angioedema, arteritis, vasculitis.

Miscellaneous:Edema (including periorbital), pyrexia, drowsiness, weakness, fatigue, lassitude, rigors, flushing, hearing loss, insomnia, pneumonitis, chills.

Read the entire FDA prescribing information for Gantrisin (Acetyl Sulfisoxazole Pediatric Suspension)


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© Gantrisin Patient Information is supplied by Cerner Multum, Inc. and Gantrisin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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