Gleostine Side Effects Center

Last updated on RxList: 9/14/2022
Gleostine Side Effects Center

What Is Gleostine?

Gleostine (lomustine) is a type of anti-cancer drug used to treat brain tumors, both primary and metastatic, in patients who have already received appropriate surgical and/or radiotherapeutic procedures, and to treat Hodgkin's disease, as secondary therapy in combination with other approved drugs in patients who relapse while being treated with primary therapy, or who fail to respond to primary therapy.

What Are Side Effects of Gleostine?

Common side effects of Gleostine include nausea and vomiting (may be severe), loss of appetite, diarrhea, mouth and lip sores, temporary hair loss, decrease in blood cell production (myelosuppression), and neurotoxicity.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Gleostine

The recommended dose of Gleostine in adult and pediatric patients as a single agent in previously untreated patients is 130 mg/m² as a single oral dose every 6 weeks.

What Drugs, Substances, or Supplements Interact with Gleostine?

Gleostine may interact with other drugs. Tell your doctor all medications and supplements you use.

Gleostine During Pregnancy and Breastfeeding

Gleostine is not recommended for use during pregnancy. It may harm a fetus. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Gleostine (lomustine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Gleostine Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • jaundice (yellowing of the skin or eyes);
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
  • signs of infection--fever, chills, sore throat, blisters or ulcers in your mouth, red or swollen gums, trouble swallowing; or
  • late-onset lung damage--new or worsening cough, chest pain, shortness of breath (may develop as long as 6 months or later after you take lomustine).

Common side effects may include:

  • nausea, vomiting;
  • delayed infection;
  • mouth sores; or
  • hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Gleostine Professional Information


The following serious adverse reactions are discussed in greater detail in other sections of the labeling:

  • Delayed myelosuppression [see WARNINGS AND PRECAUTIONS]
  • Risks of overdosage [see WARNINGS AND PRECAUTIONS]
  • Pulmonary toxicity [see WARNINGS AND PRECAUTIONS]
  • Secondary malignancies [see WARNINGS AND PRECAUTIONS]
  • Hepatotoxicity [see WARNINGS AND PRECAUTIONS]
  • Nephrotoxicity [see WARNINGS AND PRECAUTIONS]

The following adverse reactions associated with the use of Gleostine were identified in clinical trials or postmarketing reports. Because these reactions were reported from a population of uncertain size, it is not possible to estimate their frequency, reliability, or establish a causal relationship to drug exposure.

Gastrointestinal disorders: nausea, vomiting, and stomatitis

Ocular disorders: optic atrophy, visual disturbances, and blindness

Neurologic disorders: disorientation, lethargy, ataxia, and dysarthria

Other: alopecia

Read the entire FDA prescribing information for Gleostine (Lomustine Capsules)

© Gleostine Patient Information is supplied by Cerner Multum, Inc. and Gleostine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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