GlucaGen HypoKit Side Effects Center

Last updated on RxList: 9/17/2020
GlucaGen HypoKit Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is GlucaGen HypoKit?

GlucaGen HypoKit (glucagon hydrochloride kit) is an antihypoglycemic agent and a gastrointestinal motility inhibitor used to treat severe low blood sugar (hypoglycemia) reactions which may occur in patients with diabetes mellitus treated with insulin, and for use as a diagnostic aid during radiologic examinations to temporarily inhibit movement of the gastrointestinal tract.

What Are Side Effects of GlucaGen HypoKit?

Side effects of GlucaGen HypoKit include:

  • nausea,
  • vomiting, and
  • a temporary increase in blood pressure and pulse

Dosage for GlucaGen HypoKit

The dose of GlucaGen HypoKit is a 1 mL injection [adults and children, weighing more than 55 lbs. (25 kg)] or 0.5 mL [children weighing less than 55 lbs. (25 kg)] subcutaneously, intramuscularly, or intravenously. If the weight is not known: Children younger than 6 years should be given 0.5 mL and children 6 years and older should be given 1 mL.

GlucaGen HypoKit In Children

GlucaGen HypoKit is reported safe and effective for treatment of severe hypoglycemia in pediatric patients. Safety and effectiveness of GlucaGen HypoKit for use as a diagnostic aid in pediatric patients have not been established.

What Drugs, Substances, or Supplements Interact with GlucaGen HypoKit?

GlucaGen HypoKit may interact with other medicines such as:

  • beta-blockers,
  • Indomethacin,
  • anticholinergic drugs,
  • warfarin, and
  • insulin

Tell your doctor all medications and supplements you use.

GlucaGen HypoKit During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using GlucaGen HypoKit; it is unknown how it would affect a fetus. It is unknown whether GlucaGen HypoKit is excreted in breast milk. Consult your doctor before breastfeeding.

Additional Information

Our GlucaGen HypoKit (glucagon hydrochloride kit) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Diabetes is defined best as... See Answer
GlucaGen HypoKit Professional Information


The following important adverse reactions are described below and elsewhere in the labeling:

  • Hypersensitivity and Allergic Reactions [see WARNINGS AND PRECAUTIONS]
  • Necrolytic Migratory Erythema [see WARNINGS AND PRECAUTIONS]

Side effects may include nausea and vomiting at doses above 1 mg or with rapid injection. Hypotension has been reported up to 2 hours after administration in patients receiving GlucaGen as premedication for upper GI endoscopy procedures. GlucaGen exerts positive inotropic and chronotropic effects and may, therefore, cause tachycardia and hypertension. Adverse reactions indicating toxicity of GlucaGen have not been reported. A temporary increase in both blood pressure and pulse rate may occur following the administration of GlucaGen. Patients taking betablockers might be expected to have a greater increase in both pulse and blood pressure, an increase of which will be temporary because of GlucaGen's short half-life [see DRUG INTERACTIONS]. The increase in blood pressure and pulse rate may require therapy in patients with pheochromocytoma or coronary artery disease [see WARNINGS AND PRECAUTIONS]. Anaphylactic reactions may occur in some cases.

The following adverse reactions have been identified during postapproval use of GlucaGen. Because these reactions are reported voluntarily from a population of uncertain size, it is generally not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Table 1 : Frequency of Adverse Reactions

Treatment of severe hypoglycemia
Frequency (%)Adverse Reaction
< 10Nausea
< 1Vomiting
Use as a diagnostic aid
< 10Nausea
< 1Vomiting
< 1Hypoglycemia
<1Hypoglycemic coma

Necrolytic migratory erythema (NME) cases have been reported postmarketing in patients receiving continuous infusion of glucagon.

Read the entire FDA prescribing information for GlucaGen HypoKit (Glucagon Hydrochloride Kit)


Diabetes: What Raises and Lowers Your Blood Sugar Level? See Slideshow

© GlucaGen HypoKit Patient Information is supplied by Cerner Multum, Inc. and GlucaGen HypoKit Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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