Acide Glutamique, Acide Glutamique HCl, Acide L-(+)-2-Aminoglutaramique, Acide L-Glutamique, Acide L-Glutamique HCl, Alanyl-L-Glutamine Dipeptide, Éthyle Ester de Glutamine, Éthyle Ester de Glutamine HCl, GLN, Glutamate, Glutamic Acid, Glutamic Acid HCl, Glutamina, Glutaminate, Glutamine Ethyl Ester, Glutamine Ethyl Ester HCl, Glutamine Methyl Ester, Glutamine Peptides, Levoglutamide, Levoglutamine, L-(+)-2-Aminoglutaramic Acid, L-Alanyl-L-Glutamine, L-Glutamic Acid, L-Glutamic Acid HCl, L-Glutamic Acid Hydrochloride, L-Glutamic Acid 5-Amide, L-Glutamine, N-Acetyl-L-Glutamine, Peptides de Glutamine, Q, (S)-2,5-Diamino-5-oxopentanoic Acid.
Glutamine is an amino acid (a building block for proteins), found naturally in the body.
Glutamine is taken by mouth to counter some of the side effects of medical treatments. For example, it is used for side effects of cancer chemotherapy or HIV treatment including diarrhea. It is also used to reduce other side effects of cancer chemotherapy such as nerve pain, swelling inside the mouth (mucositis), loss of some white blood cells, and muscle and joint pains caused by the cancer drug Taxol. Glutamine is also used to protect the immune system and digestive system in people undergoing radiochemotherapy for cancer of the esophagus. Additionally, glutamine is used for improving recovery after bone marrow transplant or bowel surgery, increasing well-being in people who have suffered traumatic injuries, and preventing infections in critically ill people or people following burns.
Some people take glutamine by mouth for digestive system conditions such as diarrhea, inflammation of the pancreas, stomach ulcers, ulcerative colitis, and Crohn's disease, and in people with problems absorbing nutrients because they have HIV or had part of their intestines removed. It is also used for depression, moodiness, irritability, anxiety, insomnia, weight loss, and enhancing exercise performance.
People who have HIV (AIDS) sometimes take glutamine by mouth to prevent weight loss (HIV wasting). It is also used to promote muscle strength in people with cystic fibrosis or muscular dystrophy.
Glutamine is also used for attention deficit-hyperactivity disorder (ADHD), a urinary condition called cystinuria, sickle cell anemia, and for alcohol withdrawal support. In premature or very small newborns, glutamine is used to prevent death or illness.
Glutamine is given intravenously (by IV) for improving recovery after bone marrow transplant, surgery or burns. It is also used to prevent side effects of cancer chemotherapy such as pain and swelling inside the mouth (mucositis) and for preventing infections in critically ill people. In very small newborns, glutamine is used to prevent death or illness.
Glutamine powder can be ordered through most wholesale drug suppliers. Glutamine for commercial use is made by a fermentation process using bacteria that produce glutamine.
How does it work?
Glutamine is the most abundant free amino acid in the body. Amino acids are the building blocks of protein. Glutamine is produced in the muscles and is distributed by the blood to the organs that need it. Glutamine might help gut function, the immune system, and other essential processes in the body, especially in times of stress. It is also important for providing "fuel" (nitrogen and carbon) to many different cells in the body. Glutamine is needed to make other chemicals in the body such as other amino acids and glucose (sugar).
After surgery or traumatic injury, nitrogen is necessary to repair the wounds and keep the vital organs functioning. About one third of this nitrogen comes from glutamine.
If the body uses more glutamine than the muscles can make (i.e., during times of stress), muscle wasting can occur. This can occur in people with HIV/AIDS. Taking glutamine supplements might keep the glutamine stores up.
Some types of chemotherapy can reduce the levels of glutamine in the body. Glutamine treatment is thought to help prevent chemotherapy-related damage by maintaining the life of the affected tissues.
Possibly Effective for...
- Burns. Administering glutamine through a feeding tube seems to reduce infections, shorten hospital stays, and improve wound healing in people with severe burns but no lung injury. Administering glutamine through a feeding tube also seems to shorten hospital stays and reduce the risk of infections in people with severe burns and lung injury. Administering glutamine intravenously (by IV) seems to decrease the risk of some infections in people with severe burns. But it does not seem to decrease the risk of death.
- Critical illness (trauma). Although not all results are consistent, most research shows that glutamine keeps bacteria from moving out of the intestine and infecting other parts of the body after major injuries. Glutamine might also reduce the risk of hospital-acquired infections in people who are critically ill. Glutamine seems to prevent hospital-acquired infections better when given intravenously (by IV) rather than by a feeding tube. Overall, glutamine does not seem to reduce the risk of death in critically ill people.
- Treating weight loss and intestinal problems in people with HIV/AIDs disease. Taking glutamine by mouth seems to help HIV/AIDS patients absorb food better and gain weight. Doses of 40 grams per day seem to produce the best effect.
- Surgery. Giving glutamine intravenously (by IV) along with intravenous nutrition seems to improve immune function and reduce complications related to infections after surgery, especially major abdominal surgery. Giving glutamine by IV along with intravenous nutrition might also reduce the risk of infection and improve recovery after bone marrow transplants. However, not all people who receive bone marrow transplants seem to benefit. It's possible that glutamine works best in people receiving bone marrow transplants for blood tissue cancers but not solid tumors.
Possibly Ineffective for...
- Athletic performance. Taking glutamine by mouth does not seem to improve athletic performance.
- Crohn's disease. Taking glutamine by mouth does not seem to improve symptoms of Crohn's disease.
- Inherited disease that causes stones in the kidneys or bladder (Cystinuria). Taking glutamine by mouth does not seem to improve an inherited condition that causes stones to form in the kidneys or bladder.
- Early infant death. When glutamine is given to preterm infants by needle or in to the gut, illness and early death does not appear to be prevented.
- Muscular dystrophy. Research shows that taking glutamine by mouth does not improve muscle strength in children with muscular dystrophy.
Insufficient Evidence to Rate Effectiveness for...
- Diarrhea caused by drugs used to treat HIV. Early research shows that taking glutamine by mouth reduces the severity of diarrhea in people with HIV who are taking the drug nelfinavir.
- Diarrhea caused by chemotherapy treatments. Some early research shows that glutamine helps prevent diarrhea after chemotherapy. But not all research findings agree.
- Reducing damage to the immune system during cancer treatment. There is some evidence that glutamine reduces damage to the immune system caused by chemotherapy. However, not all research findings agree.
- Cystic fibrosis. Early research shows that taking glutamine by mouth does not increase protein gain in children with cystic fibrosis.
- Diarrhea. One early study shows that taking glutamine by mouth reduces the duration of diarrhea in children. But taking glutamine by mouth along with conventional rehydration solutions does not appear to have an advantage over rehydration solutions alone.
- Low birth weight. Some research suggests that using glutamine in feeding tubes decreases infections in some low birth weight infants. However, most research suggests that it does not decrease infections, increase growth, decrease the length of hospital stay, or reduce death in low birth weight infants.
- Obesity. Early research shows that taking glutamine might help with weight loss in obese women.
- Soreness and swelling inside the mouth, caused by chemotherapy treatments. In some people, taking glutamine by mouth seems to reduce soreness and swelling inside the mouth caused by chemotherapy. But it doesn't seem to benefit all chemotherapy patients. Some researchers think it works best in people with low glutamine levels during chemotherapy treatment.
- Muscle and joint pains caused by the drug paclitaxel (Taxol, used to treat cancer). There is some evidence that glutamine might help to reduce muscle and joint pains caused by paclitaxel.
- Inflammation of the pancreas (pancreatitis). An early study shows that giving glutamine intravenously (by IV) along with intravenous nutrition improves immune function but does not reduce the risk for complications or the amount of time spent in the hospital in people with pancreatitis.
- Nutrition problems after major gut surgery (short bowel syndrome). Researchers have studied whether glutamine combined with growth hormone is effective in treating short bowel syndrome. This combination seems to help some patients become less dependent on tube feeding. However, glutamine alone does not seem to be effective.
- Attention deficit-hyperactivity disorder (ADHD).
- Sickle cell anemia.
- Stomach ulcers.
- Treating alcoholism.
- Ulcerative colitis.
- Other conditions.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
Pregnancy and breast-feeding: Not enough is known about the use of glutamine during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Bone marrow transplants: Giving glutamine intravenously (by IV) might increase the risk of mouth ulcers or death in people receiving bone marrow transplant. Until more is known, avoid giving glutamine by IV to these patients. Swishing glutamine in the mouth and then swallowing might be beneficial for these patients.
Cirrhosis: Glutamine could make this condition worse. People with this condition should avoid glutamine supplements.
Severe liver disease with difficulty thinking or confusion (hepatic encephalopathy): Glutamine could make this condition worse. Do not use it.
Mania, a mental disorder: Glutamine might cause some mental changes in people with mania. Avoid use.
Monosodium glutamate (MSG) sensitivity (also known as "Chinese restaurant syndrome"): If you are sensitive to MSG, you might also be sensitive to glutamine, because the body converts glutamine to glutamate.
Seizures: There is some concern that glutamine might increase the likelihood of seizures in some people. Avoid use.
LactuloseInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Lactulose helps decrease ammonia in the body. Glutamine is changed into ammonia in the body. Taking glutamine along with lactulose might decrease the effectiveness of lactulose.
Medications for cancer (Chemotherapy)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
There is some concern that glutamine might decrease the effectiveness of some medications for cancer (chemotherapy). But it is too soon to know if this interaction occurs.
Medications used to prevent seizures (Anticonvulsants)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Medications used to prevent seizures affect chemicals in the brain. Glutamine may also affect chemicals in the brain. By affecting chemicals in the brain, glutamine may decrease the effectiveness of medications used to prevent seizures.
The following doses have been studied in scientific research:
- For burns: 0.35-0.5 grams per kilogram body weight each day or 4.3 grams every four hours.
- For critical illness or trauma: Glutamine has been given in a liquid feed at 0.2-0.6 grams per kilogram body weight each day or at a dose of 20 grams per day has been used. It is usually given for at least 5 days.
- For HIV wasting: 14-40 grams of glutamine per day has been used in combination with other nutrients.
- For burns: 0.57 grams of glutamine per kilogram body weight each day has been used for 30 days.
- For critical illness or trauma: 0.3-0.5 grams per kilogram or 18-21 grams of glutamine compounds have been given daily, sometimes with hormones.
- For reducing complications after surgery: 0.57 grams of glutamine per kilogram body weight has been used after bone marrow transplantation. Also, 20 grams of glutamine per day or 0.3 grams per kilogram body weight has been used in people undergoing surgery. Sometimes glutamine is given in the form of glutamine dipeptide. Typically 18-30 grams of glutamine dipeptide used. This amount is equivalent to 13-20 grams of glutamine.
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Albers, M. J., Steyerberg, E. W., Hazebroek, F. W., Mourik, M., Borsboom, G. J., Rietveld, T., Huijmans, J. G., and Tibboel, D. Glutamine supplementation of parenteral nutrition does not improve intestinal permeability, nitrogen balance, or outcome in newborns and infants undergoing digestive-tract surgery: results from a double-blind, randomized, controlled trial. Ann.Surg. 2005;241(4):599-606. View abstract.
Albers, S., Wernerman, J., Stehle, P., Vinnars, E., and Furst, P. Availability of amino acids supplied by constant intravenous infusion of synthetic dipeptides in healthy man. Clin.Sci (Lond) 1989;76(6):643-648. View abstract.
Albers, S., Wernerman, J., Stehle, P., Vinnars, E., and Furst, P. Availability of amino acids supplied intravenously in healthy man as synthetic dipeptides: kinetic evaluation of L-alanyl-L-glutamine and glycyl-L-tyrosine. Clin.Sci.(Lond) 1988;75(5):463-468. View abstract.
Antonio, J., Sanders, M. S., Kalman, D., Woodgate, D., and Street, C. The effects of high-dose glutamine ingestion on weightlifting performance. J.Strength.Cond.Res. 2002;16(1):157-160. View abstract.
Aosasa, S., Mochizuki, H., Yamamoto, T., Ono, S., and Ichikura, T. A clinical study of the effectiveness of oral glutamine supplementation during total parenteral nutrition: influence on mesenteric mononuclear cells. JPEN J.Parenter.Enteral Nutr. 1999;23(5 Suppl):S41-S44. View abstract.
Aquino, V. M., Harvey, A. R., Garvin, J. H., Godder, K. T., Nieder, M. L., Adams, R. H., Jackson, G. B., and Sandler, E. S. A double-blind randomized placebo-controlled study of oral glutamine in the prevention of mucositis in children undergoing hematopoietic stem cell transplantation: a pediatric blood and marrow transplant consortium study. Bone Marrow Transplant. 2005;36(7):611-616. View abstract.
Bakalar, B., Duska, F., Pachl, J., Fric, M., Otahal, M., Pazout, J., and Andel, M. Parenterally administered dipeptide alanyl-glutamine prevents worsening of insulin sensitivity in multiple-trauma patients. Crit Care Med 2006;34(2):381-386. View abstract.
Barbosa, E., Moreira, E. A., Goes, J. E., and Faintuch, J. Pilot study with a glutamine-supplemented enteral formula in critically ill infants. Rev.Hosp.Clin.Fac.Med.Sao Paulo 1999;54(1):21-24. View abstract.
Blijlevens, N. M., Donnelly, J. P., Naber, A. H., Schattenberg, A. V., and DePauw, B. E. A randomised, double-blinded, placebo-controlled, pilot study of parenteral glutamine for allogeneic stem cell transplant patients. Support.Care Cancer 2005;13(10):790-796. View abstract.
Bober-Olesinska, K. and Kornacka, M. K. [Effects of glutamine supplemented parenteral nutrition on the incidence of necrotizing enterocolitis, nosocomial sepsis and length of hospital stay in very low birth weight infants]. Med Wieku.Rozwoj. 2005;9(3 Pt 1):325-333. View abstract.
Boelens, P. G., Houdijk, A. P., Fonk, J. C., Nijveldt, R. J., Ferwerda, C. C., von Blomberg-van der Flier BM, Thijs, L. G., Haarman, H. J., Puyana, J. C., and van Leeuwen, P. A. Glutamine-enriched enteral nutrition increases HLA-DR expression on monocytes of trauma patients. J.Nutr. 2002;132(9):2580-2586. View abstract.
Boelens, P. G., Houdijk, A. P., Fonk, J. C., Puyana, J. C., Haarman, H. J., von Blomberg-van der Flier ME, and van Leeuwen, P. A. Glutamine-enriched enteral nutrition increases in vitro interferon-gamma production but does not influence the in vivo specific antibody response to KLH after severe trauma. A prospective, double blind, randomized clinical study. Clin.Nutr. 2004;23(3):391-400. View abstract.
Borel, M. J., Williams, P. E., Jabbour, K., Levenhagen, D., Kaizer, E., and Flakoll, P. J. Parenteral glutamine infusion alters insulin-mediated glucose metabolism. JPEN J Parenter.Enteral Nutr. 1998;22(5):280-285. View abstract.
Buchman, A. L. Glutamine for short-bowel syndrome. Curr.Gastroenterol.Rep. 2002;4(4):321. View abstract.
Byrne, T. A., Wilmore, D. W., Iyer, K., Dibaise, J., Clancy, K., Robinson, M. K., Chang, P., Gertner, J. M., and Lautz, D. Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome: a prospective, randomized, placebo-controlled, double-blind clinical trial. Ann.Surg. 2005;242(5):655-661. View abstract.
Candow, D. G., Chilibeck, P. D., Burke, D. G., Davison, K. S., and Smith-Palmer, T. Effect of glutamine supplementation combined with resistance training in young adults. Eur.J.Appl.Physiol 2001;86(2):142-149. View abstract.
Canovas, G., Leon-Sanz, M., Gomez, P., Valero, M. A., Gomis, P., and La Huerta, J. J. Oral glutamine supplements in autologous hematopoietic transplant: impact on gastrointestinal toxicity and plasma protein levels. Haematologica 2000;85(11):1229-1230. View abstract.
Carroll, P. V., Jackson, N. C., Russell-Jones, D. L., Treacher, D. F., Sonksen, P. H., and Umpleby, A. M. Combined growth hormone/insulin-like growth factor I in addition to glutamine-supplemented TPN results in net protein anabolism in critical illness. Am.J.Physiol Endocrinol.Metab 2004;286(1):E151-E157. View abstract.
Castell, L. M., Poortmans, J. R., and Newsholme, E. A. Does glutamine have a role in reducing infections in athletes? Eur.J.Appl.Physiol Occup.Physiol 1996;73(5):488-490. View abstract.
Chen, G., Xie, W., and Jiang, H. [Clinical observation of the protective effect of oral feeding of glutamine granules on intestinal mucous membrane]. Zhonghua Shao Shang Za Zhi. 2001;17(4):210-211. View abstract.
Claeyssens, S., Bouteloup-Demange, C., Gachon, P., Hecketsweiler, B., Lerebours, E., Lavoinne, A., and Dechelotte, P. Effect of enteral glutamine on leucine, phenylalanine and glutamine metabolism in hypercortisolemic subjects. Am.J.Physiol Endocrinol.Metab 2000;278(5):E817-E824. View abstract.
Coeffier, M., Claeyssens, S., Hecketsweiler, B., Lavoinne, A., Ducrotte, P., and Dechelotte, P. Enteral glutamine stimulates protein synthesis and decreases ubiquitin mRNA level in human gut mucosa. Am.J.Physiol Gastrointest.Liver Physiol 2003;285(2):G266-G273. View abstract.
Coeffier, M., Hecketsweiler, B., Hecketsweiler, P., and Dechelotte, P. Effect of glutamine on water and sodium absorption in human jejunum at baseline and during PGE1-induced secretion. J Appl.Physiol 2005;98(6):2163-2168. View abstract.
Conejero, R., Bonet, A., Grau, T., Esteban, A., Mesejo, A., Montejo, J. C., Lopez, J., and Acosta, J. A. Effect of a glutamine-enriched enteral diet on intestinal permeability and infectious morbidity at 28 days in critically ill patients with systemic inflammatory response syndrome: a randomized, single-blind, prospective, multicenter study. Nutrition 2002;18(9):716-721. View abstract.
Darmaun, D., Hayes, V., Schaeffer, D., Welch, S., and Mauras, N. Effects of glutamine and recombinant human growth hormone on protein metabolism in prepubertal children with cystic fibrosis. J.Clin.Endocrinol.Metab 2004;89(3):1146-1152. View abstract.
de Beaux, A. C., O'Riordain, M. G., Ross, J. A., Jodozi, L., Carter, D. C., and Fearon, K. C. Glutamine-supplemented total parenteral nutrition reduces blood mononuclear cell interleukin-8 release in severe acute pancreatitis. Nutrition 1998;14(3):261-265. View abstract.
Dechelotte, P., Darmaun, D., Rongier, M., Hecketsweiler, B., Rigal, O., and Desjeux, J. F. Absorption and metabolic effects of enterally administered glutamine in humans. Am.J.Physiol 1991;260(5 Pt 1):G677-G682. View abstract.
Dechelotte, P., Hasselmann, M., Cynober, L., Allaouchiche, B., Coeffier, M., Hecketsweiler, B., Merle, V., Mazerolles, M., Samba, D., Guillou, Y. M., Petit, J., Mansoor, O., Colas, G., Cohendy, R., Barnoud, D., Czernichow, P., and Bleichner, G. L-alanyl-L-glutamine dipeptide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter study. Crit Care Med 2006;34(3):598-604. View abstract.
des, Robert C., Le Bacquer, O., Piloquet, H., Roze, J. C., and Darmaun, D. Acute effects of intravenous glutamine supplementation on protein metabolism in very low birth weight infants: a stable isotope study. Pediatr.Res. 2002;51(1):87-93. View abstract.
Duggan, C., Stark, A. R., Auestad, N., Collier, S., Fulhan, J., Gura, K., Utter, S., Teixeira-Pinto, A., Donovan, K., and Lund, D. Glutamine supplementation in infants with gastrointestinal disease: a randomized, placebo-controlled pilot trial. Nutrition 2004;20(9):752-756. View abstract.
Escolar, D. M., Buyse, G., Henricson, E., Leshner, R., Florence, J., Mayhew, J., Tesi-Rocha, C., Gorni, K., Pasquali, L., Patel, K. M., McCarter, R., Huang, J., Mayhew, T., Bertorini, T., Carlo, J., Connolly, A. M., Clemens, P. R., Goemans, N., Iannaccone, S. T., Igarashi, M., Nevo, Y., Pestronk, A., Subramony, S. H., Vedanarayanan, V. V., and Wessel, H. CINRG randomized controlled trial of creatine and glutamine in Duchenne muscular dystrophy. Ann Neurol 2005;58(1):151-155. View abstract.
Exner, R., Tamandl, D., Goetzinger, P., Mittlboeck, M., Fuegger, R., Sautner, T., Spittler, A., and Roth, E. Perioperative GLY-GLN infusion diminishes the surgery-induced period of immunosuppression: accelerated restoration of the lipopolysaccharide-stimulated tumor necrosis factor-alpha response. Ann.Surg. 2003;237(1):110-115. View abstract.
Fuentes-Orozco, C., Anaya-Prado, R., Gonzalez-Ojeda, A., Arenas-Marquez, H., Cabrera-Pivaral, C., Cervantes-Guevara, G., and Barrera-Zepeda, L. M. L-alanyl-L-glutamine-supplemented parenteral nutrition improves infectious morbidity in secondary peritonitis. Clin.Nutr. 2004;23(1):13-21. View abstract.
Garrel, D., Patenaude, J., Nedelec, B., Samson, L., Dorais, J., Champoux, J., D'Elia, M., and Bernier, J. Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: a prospective, controlled, randomized clinical trial. Crit Care Med. 2003;31(10):2444-2449. View abstract.
Giris, M., Erbil, Y., Dogru-Abbasoglu, S., Yanik, B. T., Alis, H., Olgac, V., and Toker, G. A. The effect of heme oxygenase-1 induction by glutamine on TNBS-induced colitis. The effect of glutamine on TNBS colitis. Int J Colorectal Dis. 2007;22(6):591-599. View abstract.
Goeters, C., Wenn, A., Mertes, N., Wempe, C., Van Aken, H., Stehle, P., and Bone, H. G. Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients. Crit Care Med. 2002;30(9):2032-2037. View abstract.
Griffiths, R. D. Outcome of critically ill patients after supplementation with glutamine. Nutrition 1997;13(7-8):752-754. View abstract.
Griffiths, R. D., Allen, K. D., Andrews, F. J., and Jones, C. Infection, multiple organ failure, and survival in the intensive care unit: influence of glutamine-supplemented parenteral nutrition on acquired infection. Nutrition 2002;18(7-8):546-552. View abstract.
Griffiths, R. D., Jones, C., and Palmer, T. E. Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition. Nutrition 1997;13(4):295-302. View abstract.
Haisch, M., Fukagawa, N. K., and Matthews, D. E. Oxidation of glutamine by the splanchnic bed in humans. Am.J.Physiol Endocrinol.Metab 2000;278(4):E593-E602. View abstract.
Hall, J. C., Dobb, G., Hall, J., de Sousa, R., Brennan, L., and McCauley, R. A prospective randomized trial of enteral glutamine in critical illness. Intensive Care Med. 2003;29(10):1710-1716. View abstract.
Hallay, J., Kovacs, G., Kiss, Sz S., Farkas, M., Lakos, G., Sipka, S., Bodolay, E., and Sapy, P. Changes in the nutritional state and immune-serological parameters of esophagectomized patients fed jejunaly with glutamine-poor and glutamine-rich nutriments. Hepatogastroenterology 2002;49(48):1555-1559. View abstract.
Hammarqvist, F., Wernerman, J., von der, Decken A., and Vinnars, E. Alanyl-glutamine counteracts the depletion of free glutamine and the postoperative decline in protein synthesis in skeletal muscle. Ann.Surg. 1990;212(5):637-644. View abstract.
Hankard, R. G., Darmaun, D., Sager, B. K., D'Amore, D., Parsons, W. R., and Haymond, M. Response of glutamine metabolism to exogenous glutamine in humans. Am.J.Physiol 1995;269(4 Pt 1):E663-E670. View abstract.
Hankard, R. G., Haymond, M. W., and Darmaun, D. Effect of glutamine on leucine metabolism in humans. Am.J.Physiol 1996;271(4 Pt 1):E748-E754. View abstract.
Huang, E. Y., Leung, S. W., Wang, C. J., Chen, H. C., Sun, L. M., Fang, F. M., Yeh, S. A., Hsu, H. C., and Hsiung, C. Y. Oral glutamine to alleviate radiation-induced oral mucositis: a pilot randomized trial. Int.J.Radiat.Oncol.Biol.Phys. 2-1-2000;46(3):535-539. View abstract.
Huffman, F. G. and Walgren, M. E. L-glutamine supplementation improves nelfinavir-associated diarrhea in HIV-infected individuals. HIV.Clin.Trials 2003;4(5):324-329. View abstract.
Iwashita, S., Mikus, C., Baier, S., and Flakoll, P. J. Glutamine supplementation increases postprandial energy expenditure and fat oxidation in humans. JPEN J Parenter.Enteral Nutr. 2006;30(2):76-80. View abstract.
Iwashita, S., Williams, P., Jabbour, K., Ueda, T., Kobayashi, H., Baier, S., and Flakoll, P. J. Impact of glutamine supplementation on glucose homeostasis during and after exercise. J Appl.Physiol 2005;99(5):1858-1865. View abstract.
Jacobi, C. A., Ordemann, J., Zuckermann, H., Docke, W., Volk, H. D., and Muller, J. M. [Effect of alanyl-glutamine in postoperative total parenteral nutrition on postoperative immunosuppression and morbidity. Preliminary results of a prospective randomized study]. Langenbecks Arch.Chir Suppl Kongressbd. 1998;115:605-611. View abstract.
Jacobi, C. A., Ordemann, J., Zuckermann, H., Docke, W., Volk, H. D., and Muller, J. M. [The influence of alanyl-glutamine on immunologic functions and morbidity in postoperative total parenteral nutrition. Preliminary results of a prospective randomized trial]. Zentralbl.Chir 1999;124(3):199-205. View abstract.
Jacobson, S. D., Loprinzi, C. L., Sloan, J. A., Wilke, J. L., Novotny, P. J., Okuno, S. H., Jatoi, A., and Moynihan, T. J. Glutamine does not prevent paclitaxel-associated myalgias and arthralgias. J.Support.Oncol. 2003;1(4):274-278. View abstract.
Juretic, A., Spagnoli, G. C., Horig, H., Babst, R., von, Bremen K., Harder, F., and Heberer, M. Glutamine requirements in the generation of lymphokine-activated killer cells. Clin.Nutr. 1994;13(1):42-49. View abstract.
Kalhan, S. C., Parimi, P. S., Gruca, L. L., and Hanson, R. W. Glutamine supplement with parenteral nutrition decreases whole body proteolysis in low birth weight infants. J Pediatr. 2005;146(5):642-647. View abstract.
Klek, S., Kulig, J., Szczepanik, A. M., Jedrys, J., and Kolodziejczyk, P. The clinical value of parenteral immunonutrition in surgical patients. Acta Chir Belg. 2005;105(2):175-179. View abstract.
Kozelsky, T. F., Meyers, G. E., Sloan, J. A., Shanahan, T. G., Dick, S. J., Moore, R. L., Engeler, G. P., Frank, A. R., McKone, T. K., Urias, R. E., Pilepich, M. V., Novotny, P. J., and Martenson, J. A. Phase III double-blind study of glutamine versus placebo for the prevention of acute diarrhea in patients receiving pelvic radiation therapy. J.Clin.Oncol. 5-1-2003;21(9):1669-1674. View abstract.
Krieger, J. W., Crowe, M., and Blank, S. E. Chronic glutamine supplementation increases nasal but not salivary IgA during 9 days of interval training. J.Appl.Physiol 2004;97(2):585-591. View abstract.
Krzywkowski, K., Petersen, E. W., Ostrowski, K., Kristensen, J. H., Boza, J., and Pedersen, B. K. Effect of glutamine supplementation on exercise-induced changes in lymphocyte function. Am.J.Physiol Cell Physiol 2001;281(4):C1259-C1265. View abstract.
Lacey, J. M., Crouch, J. B., Benfell, K., Ringer, S. A., Wilmore, C. K., Maguire, D., and Wilmore, D. W. The effects of glutamine-supplemented parenteral nutrition in premature infants. JPEN J.Parenter.Enteral Nutr. 1996;20(1):74-80. View abstract.
Lehmkuhl, M., Malone, M., Justice, B., Trone, G., Pistilli, E., Vinci, D., Haff, E. E., Kilgore, J. L., and Haff, G. G. The effects of 8 weeks of creatine monohydrate and glutamine supplementation on body composition and performance measures. J Strength.Cond.Res 2003;17(3):425-438. View abstract.
Lima, A. A., Brito, L. F., Ribeiro, H. B., Martins, M. C., Lustosa, A. P., Rocha, E. M., Lima, N. L., Monte, C. M., and Guerrant, R. L. Intestinal barrier function and weight gain in malnourished children taking glutamine supplemented enteral formula. J Pediatr.Gastroenterol.Nutr. 2005;40(1):28-35. View abstract.
Lin, M. T., Kung, S. P., Yeh, S. L., Liaw, K. Y., Wang, M. Y., Kuo, M. L., Lee, P. H., and Chen, W. J. Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity. World J Gastroenterol. 10-21-2005;11(39):6197-6201. View abstract.
Lin, M. T., Kung, S. P., Yeh, S. L., Lin, C., Lin, T. H., Chen, K. H., Liaw, K. Y., Lee, P. H., Chang, K. J., and Chen, W. J. The effect of glutamine-supplemented total parenteral nutrition on nitrogen economy depends on severity of diseases in surgical patients. Clin.Nutr. 2002;21(3):213-218. View abstract.
M'bemba, J., Cynober, L., de, Bandt P., Taverna, M., Chevalier, A., Bardin, C., Slama, G., and Selam, J. L. Effects of dipeptide administration on hypoglycaemic counterregulation in type 1 diabetes. Diabetes Metab 2003;29(4 Pt 1):412-417. View abstract.
MacBurney, M., Young, L. S., Ziegler, T. R., and Wilmore, D. W. A cost-evaluation of glutamine-supplemented parenteral nutrition in adult bone marrow transplant patients. J.Am.Diet.Assoc. 1994;94(11):1263-1266. View abstract.
May, P. E., Barber, A., D'Olimpio, J. T., Hourihane, A., and Abumrad, N. N. Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine. Am.J.Surg. 2002;183(4):471-479. View abstract.
Mok, E., Eleouet-Da, Violante C., Daubrosse, C., Gottrand, F., Rigal, O., Fontan, J. E., Cuisset, J. M., Guilhot, J., and Hankard, R. Oral glutamine and amino acid supplementation inhibit whole-body protein degradation in children with Duchenne muscular dystrophy. Am.J Clin.Nutr. 2006;83(4):823-828. View abstract.
Morais, A. A., Santos, J. E., and Faintuch, J. [Comparative study of arginine and glutamine supplements in malnourished surgical patients]. Rev.Hosp.Clin.Fac.Med.Sao Paulo 1995;50(5):276-279. View abstract.
Morlion, B. J., Siedhoff, H. P., Joosten, U., Koller, M., Konig, W., Furst, P., and Puchstein, C. [Immunomodulation after parenteral glutamine administration in colorectal surgery]. Langenbecks Arch.Chir Suppl Kongressbd. 1996;113:342-344. View abstract.
Neri, A., Mariani, F., Piccolomini, A., Testa, M., Vuolo, G., and Di Cosmo, L. Glutamine-supplemented total parenteral nutrition in major abdominal surgery. Nutrition 2001;17(11-12):968-969. View abstract.
Neu, J., Roig, J. C., Meetze, W. H., Veerman, M., Carter, C., Millsaps, M., Bowling, D., Dallas, M. J., Sleasman, J., Knight, T., and Auestad, N. Enteral glutamine supplementation for very low birth weight infants decreases morbidity. J.Pediatr. 1997;131(5):691-699. View abstract.
O'Riordain, M. G., De Beaux, A., and Fearon, K. C. Effect of glutamine on immune function in the surgical patient. Nutrition 1996;12(11-12 Suppl):S82-S84. View abstract.
O'Riordain, M. G., Fearon, K. C., Ross, J. A., Rogers, P., Falconer, J. S., Bartolo, D. C., Garden, O. J., and Carter, D. C. Glutamine-supplemented total parenteral nutrition enhances T-lymphocyte response in surgical patients undergoing colorectal resection. Ann.Surg. 1994;220(2):212-221. View abstract.
Ockenga, J., Borchert, K., Rifai, K., Manns, M. P., and Bischoff, S. C. Effect of glutamine-enriched total parenteral nutrition in patients with acute pancreatitis. Clin.Nutr. 2002;21(5):409-416. View abstract.
Peng, X., Yan, H., You, Z., Wang, P., and Wang, S. Clinical and protein metabolic efficacy of glutamine granules-supplemented enteral nutrition in severely burned patients. Burns 2005;31(3):342-346. View abstract.
Peng, X., Yan, H., You, Z., Wang, P., and Wang, S. Effects of enteral supplementation with glutamine granules on intestinal mucosal barrier function in severe burned patients. Burns 2004;30(2):135-139. View abstract.
Peng, X., You, Z. Y., Huang, X. K., Zhang, S. Q., He, G. Z., Xie, W. G., and Quan, Z. F. [Effects of glutamine granules on protein metabolism in trauma patients]. Zhonghua Wai Ke.Za Zhi. 4-7-2004;42(7):406-409. View abstract.
Pertkiewicz, M., Slotwinski, R., Majewska, K., and Szczygiel, B. [Clinical evaluation of amino acid solution]. Pol.Merkur Lekarski. 1999;7(41):211-214. View abstract.
Petersson, B., von der, Decken A., Vinnars, E., and Wernerman, J. Long-term effects of postoperative total parenteral nutrition supplemented with glycylglutamine on subjective fatigue and muscle protein synthesis. Br.J Surg. 1994;81(10):1520-1523. View abstract.
Piccirillo, N., De Matteis, S., Laurenti, L., Chiusolo, P., Sora, F., Pittiruti, M., Rutella, S., Cicconi, S., Fiorini, A., D'Onofrio, G., Leone, G., and Sica, S. Glutamine-enriched parenteral nutrition after autologous peripheral blood stem cell transplantation: effects on immune reconstitution and mucositis. Haematologica 2003;88(2):192-200. View abstract.
Poindexter, B. B., Ehrenkranz, R. A., Stoll, B. J., Wright, L. L., Poole, W. K., Oh, W., Bauer, C. R., Papile, L. A., Tyson, J. E., Carlo, W. A., Laptook, A. R., Narendran, V., Stevenson, D. K., Fanaroff, A. A., Korones, S. B., Shankaran, S., Finer, N. N., and Lemons, J. A. Parenteral glutamine supplementation does not reduce the risk of mortality or late-onset sepsis in extremely low birth weight infants. Pediatrics 2004;113(5):1209-1215. View abstract.
Powell-Tuck, J. Total parenteral nutrition with glutamine dipeptide shortened hospital stays and improved immune status and nitrogen economy after major abdominal surgery. Gut 1999;44(2):155. View abstract.
Prada, P. O., Hirabara, S. M., de Souza, C. T., Schenka, A. A., Zecchin, H. G., Vassallo, J., Velloso, L. A., Carneiro, E., Carvalheira, J. B., Curi, R., and Saad, M. J. L-glutamine supplementation induces insulin resistance in adipose tissue and improves insulin signalling in liver and muscle of rats with diet-induced obesity. Diabetologia 2007;50(9):1949-1959. View abstract.
Pytlik, R., Benes, P., Patorkova, M., Chocenska, E., Gregora, E., Prochazka, B., and Kozak, T. Standardized parenteral alanyl-glutamine dipeptide supplementation is not beneficial in autologous transplant patients: a randomized, double-blind, placebo controlled study. Bone Marrow Transplant. 2002;30(12):953-961. View abstract.
Pytlik, R., Gregora, E., Benes, P., and Kozak, T. [Effect of parenteral glutamine on restoration of lymphocyte subpopulations after high-dose chemotherapy and autologous hematopoietic cell transplantation: data from a double-blind randomized study]. Epidemiol.Mikrobiol.Imunol. 2002;51(4):152-155. View abstract.
Quan, Z. F., Yang, C., Li, N., and Li, J. S. Effect of glutamine on change in early postoperative intestinal permeability and its relation to systemic inflammatory response. World J.Gastroenterol. 7-1-2004;10(13):1992-1994. View abstract.
Rogeri, P. S. and Costa Rosa, L. F. Plasma glutamine concentration in spinal cord injured patients. Life Sci 9-23-2005;77(19):2351-2360. View abstract.
Sax, H. C. Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition after bone marrow transplantation. A randomized, double-blind, controlled study. JPEN J.Parenter.Enteral Nutr. 1992;16(6):589-590. View abstract.
Scheid, C., Hermann, K., Kremer, G., Holsing, A., Heck, G., Fuchs, M., Waldschmidt, D., Herrmann, H. J., Sohngen, D., Diehl, V., and Schwenk, A. Randomized, double-blind, controlled study of glycyl-glutamine-dipeptide in the parenteral nutrition of patients with acute leukemia undergoing intensive chemotherapy. Nutrition 2004;20(3):249-254. View abstract.
Scheltinga, M. R., Young, L. S., Benfell, K., Bye, R. L., Ziegler, T. R., Santos, A. A., Antin, J. H., Schloerb, P. R., and Wilmore, D. W. Glutamine-enriched intravenous feedings attenuate extracellular fluid expansion after a standard stress. Ann.Surg. 1991;214(4):385-393. View abstract.
Schloerb, P. R. and Amare, M. Total parenteral nutrition with glutamine in bone marrow transplantation and other clinical applications (a randomized, double-blind study). JPEN J.Parenter.Enteral Nutr. 1993;17(5):407-413. View abstract.
Schulman, A. S., Willcutts, K. F., Claridge, J. A., Evans, H. L., Radigan, A. E., O'Donnell, K. B., Camden, J. R., Chong, T. W., McElearney, S. T., Smith, R. L., Gazoni, L. M., Farinholt, H. M., Heuser, C. C., Lowson, S. M., Schirmer, B. D., Young, J. S., and Sawyer, R. G. Does the addition of glutamine to enteral feeds affect patient mortality? Crit Care Med 2005;33(11):2501-2506. View abstract.
Schulman, A. S., Willcutts, K. F., Claridge, J. A., O'Donnell, K. B., Radigan, A. E., Evans, H. L., McElearney, S. T., Hedrick, T. L., Lowson, S. M., Schirmer, B. D., Young, J. S., and Sawyer, R. G. Does enteral glutamine supplementation decrease infectious morbidity? Surg.Infect.(Larchmt.) 2006;7(1):29-35. View abstract.
Sheridan, R. L., Prelack, K., Yu, Y. M., Lydon, M., Petras, L., Young, V. R., and Tompkins, R. G. Short-term enteral glutamine does not enhance protein accretion in burned children: a stable isotope study. Surgery 2004;135(6):671-678. View abstract.
Spittler, A., Sautner, T., Gornikiewicz, A., Manhart, N., Oehler, R., Bergmann, M., Fugger, R., and Roth, E. Postoperative glycyl-glutamine infusion reduces immunosuppression: partial prevention of the surgery induced decrease in HLA-DR expression on monocytes. Clin.Nutr. 2001;20(1):37-42. View abstract.
Stehle, P., Zander, J., Mertes, N., Albers, S., Puchstein, C., Lawin, P., and Furst, P. Effect of parenteral glutamine peptide supplements on muscle glutamine loss and nitrogen balance after major surgery. Lancet 2-4-1989;1(8632):231-233. View abstract.
Stubblefield, M. D., Vahdat, L. T., Balmaceda, C. M., Troxel, A. B., Hesdorffer, C. S., and Gooch, C. L. Glutamine as a neuroprotective agent in high-dose paclitaxel-induced peripheral neuropathy: a clinical and electrophysiologic study. Clin.Oncol.(R.Coll.Radiol.) 2005;17(4):271-276. View abstract.
Suojaranta-Ylinen, R., Ruokonen, E., Pulkki, K., Mertsola, J., and Takala, J. Preoperative glutamine loading does not prevent endotoxemia in cardiac surgery. Acta Anaesthesiol.Scand. 1997;41(3):385-391. View abstract.
Sykorova, A., Horacek, J., Zak, P., Kmonicek, M., Bukac, J., and Maly, J. A randomized, double blind comparative study of prophylactic parenteral nutritional support with or without glutamine in autologous stem cell transplantation for hematological malignancies -- three years' follow-up. Neoplasma 2005;52(6):476-482. View abstract.
Thompson, S. W., McClure, B. G., and Tubman, T. R. A randomized, controlled trial of parenteral glutamine in ill, very low birth-weight neonates. J.Pediatr.Gastroenterol.Nutr. 2003;37(5):550-553. View abstract.
Tjader, I., Rooyackers, O., Forsberg, A. M., Vesali, R. F., Garlick, P. J., and Wernerman, J. Effects on skeletal muscle of intravenous glutamine supplementation to ICU patients. Intensive Care Med. 2004;30(2):266-275. View abstract.
van den Berg, A., van Elburg, R. M., Twisk, J. W., and Fetter, W. P. Glutamine-enriched enteral nutrition in very low birth weight infants. Design of a double-blind randomised controlled trial [ISRCTN73254583]. BMC.Pediatr. 9-1-2004;4:17. View abstract.
van den Berg, A., van Elburg, R. M., Westerbeek, E. A., Twisk, J. W., and Fetter, W. P. Glutamine-enriched enteral nutrition in very-low-birth-weight infants and effects on feeding tolerance and infectious morbidity: a randomized controlled trial. Am.J Clin.Nutr. 2005;81(6):1397-1404. View abstract.
van Hall, G., Saris, W. H., van de Schoor, P. A., and Wagenmakers, A. J. The effect of free glutamine and peptide ingestion on the rate of muscle glycogen resynthesis in man. Int.J.Sports Med. 2000;21(1):25-30. View abstract.
van Loon, F. P., Banik, A. K., Nath, S. K., Patra, F. C., Wahed, M. A., Darmaun, D., Desjeux, J. F., and Mahalanabis, D. The effect of L-glutamine on salt and water absorption: a jejunal perfusion study in cholera in humans. Eur.J.Gastroenterol.Hepatol. 1996;8(5):443-448. View abstract.
Vaughn, P., Thomas, P., Clark, R., and Neu, J. Enteral glutamine supplementation and morbidity in low birth weight infants. J.Pediatr. 2003;142(6):662-668. View abstract.
Velasco, N., Hernandez, G., Wainstein, C., Castillo, L., Maiz, A., Lopez, F., Guzman, S., Bugedo, G., Acosta, A. M., and Bruhn, A. Influence of polymeric enteral nutrition supplemented with different doses of glutamine on gut permeability in critically ill patients. Nutrition 2001;17(11-12):907-911. View abstract.
Vicario, M., Amat, C., Rivero, M., Moreto, M., and Pelegri, C. Dietary glutamine affects mucosal functions in rats with mild DSS-induced colitis. J Nutr. 2007;137(8):1931-1937. View abstract.
Walsh, N. P., Blannin, A. K., Bishop, N. C., Robson, P. J., and Gleeson, M. Effect of oral glutamine supplementation on human neutrophil lipopolysaccharide-stimulated degranulation following prolonged exercise. Int.J.Sport Nutr.Exerc.Metab 2000;10(1):39-50. View abstract.
Williams, J. Z., Abumrad, N., and Barbul, A. Effect of a specialized amino acid mixture on human collagen deposition. Ann.Surg. 2002;236(3):369-374. View abstract.
Williams, R., Olivi, S., Li, C. S., Storm, M., Cremer, L., Mackert, P., and Wang, W. Oral glutamine supplementation decreases resting energy expenditure in children and adolescents with sickle cell anemia. J.Pediatr.Hematol.Oncol. 2004;26(10):619-625. View abstract.
Wischmeyer, P. E., Lynch, J., Liedel, J., Wolfson, R., Riehm, J., Gottlieb, L., and Kahana, M. Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control. Crit Care Med. 2001;29(11):2075-2080. View abstract.
Wischmeyer, P., Pemberton, J. H., and Phillips, S. F. Chronic pouchitis after ileal pouch-anal anastomosis: responses to butyrate and glutamine suppositories in a pilot study. Mayo Clin.Proc. 1993;68(10):978-981. View abstract.
Yalcin, S. S., Yurdakok, K., Tezcan, I., and Oner, L. Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea. J.Pediatr.Gastroenterol.Nutr. 2004;38(5):494-501. View abstract.
Yao, G. X., Xue, X. B., Jiang, Z. M., Yang, N. F., and Wilmore, D. W. Effects of perioperative parenteral glutamine-dipeptide supplementation on plasma endotoxin level, plasma endotoxin inactivation capacity and clinical outcome. Clin.Nutr. 2005;24(4):510-515. View abstract.
Yoshida, S., Kaibara, A., Ishibashi, N., and Shirouzu, K. Glutamine supplementation in cancer patients. Nutrition 2001;17(9):766-768. View abstract.
Young, L. S., Bye, R., Scheltinga, M., Ziegler, T. R., Jacobs, D. O., and Wilmore, D. W. Patients receiving glutamine-supplemented intravenous feedings report an improvement in mood. JPEN J.Parenter.Enteral Nutr. 1993;17(5):422-427. View abstract.
Zhou, Y. P., Jiang, Z. M., Sun, Y. H., Wang, X. R., Ma, E. L., and Wilmore, D. The effect of supplemental enteral glutamine on plasma levels, gut function, and outcome in severe burns: a randomized, double-blind, controlled clinical trial. JPEN J.Parenter.Enteral Nutr. 2003;27(4):241-245. View abstract.
Zhou, Y., Jiang, Z., and Sun, Y. [Glutamine dipeptide enriched enteral nutrition improving gut permeability in sever burns]. Zhonghua Yi.Xue.Za Zhi. 1999;79(11):825-827. View abstract.
Zhou, Y., Sun, Y., Jiang, Z., He, G., and Yang, N. [The effects of glutamine dipeptide on the improvement of endotoxemia in severely burned patients]. Zhonghua Shao Shang Za Zhi. 2002;18(6):343-345. View abstract.
Zhu, M., Tang, D., Zhao, X., Cao, J., Wei, J., Chen, Y., Xiao, L., and Sun, Q. [Impact of glutamine of gut permeability and clinical prognosis on the aging patients undergoing gastric-intestinal operation]. Zhongguo Yi.Xue.Ke.Xue.Yuan Xue.Bao. 2000;22(5):425-427. View abstract.
Ziegler, T. R., Ogden, L. G., Singleton, K. D., Luo, M., Fernandez-Estivariz, C., Griffith, D. P., Galloway, J. R., and Wischmeyer, P. E. Parenteral glutamine increases serum heat shock protein 70 in critically ill patients. Intensive Care Med 2005;31(8):1079-1086. View abstract.
Akobeng AK, Miller V, Stanton J, et al. Double-blind, randomized, controlled trial of glutamine-enriched polymeric diet in the treatment of active Crohn's disease. J Pediatr Gastroenterol Nutr 2000;30:78-84.. View abstract.
Alverdy JC. Effects of glutamine-supplemented diets on immunology of the gut. JPEN J Parenter Enteral Nutr 1990;14:109S-13S.. View abstract.
Amores-Sanchez MI, Medina MA. Glutamine, as a precursor of glutathione, and oxidative stress. Mol Genet Metab 1999;67:100-5.. View abstract.
Anderson PM, Ramsay NK, Shu XO, et al. Effect of low-dose oral glutamine on painful stomatitis during bone marrow transplantation. Bone Marrow Transplant 1998;22:339-44.. View abstract.
Anderson PM, Schroeder G, Skubitz KM. Oral glutamine reduces the duration and severity of stomatitis after cytotoxic cancer chemotherapy. Cancer 1998;83:1433-9. View abstract.
Antonio J, Street C. Glutamine: a potentially useful supplement for athletes. Can J Appl Physiol 1999;24:1-14.. View abstract.
Bowtell JL, Gelly K, Jackman ML, et al. Effect of oral glutamine on whole body carbohydrate storage during recovery from exhaustive exercise. J Appl Physiol 1999;86:1770-7. View abstract.
Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. View abstract.
Brown SA, Goringe A, Fegan C, et al. Parenteral glutamine protects hepatic function during bone marrow transplantation. Bone Marrow Transplant 1998;22:281-4.. View abstract.
Byrne TA, Morrissey TB, Nattakom TV, et al. Growth hormone, glutamine, and a modified diet enhance nutrient absorption in patients with severe short bowel syndrome. JPEN J Parenter Enteral Nutr 1995;19:296-302.. View abstract.
Byrne TA, Persinger RL, Young LS, et al. A new treatment for patients with short-bowel syndrome. Growth hormone, glutamine, and a modified diet. Ann Surg 1995;222:243-54.. View abstract.
Castell LM, Newsholme EA. Glutamine and the effects of exhaustive exercise upon the immune response. Can J Physiol Pharmacol 1998;76:524-32.. View abstract.
Castell LM, Newsholme EA. The effects of oral glutamine supplementation on athletes after prolonged, exhaustive exercise. Nutrition 1997;13:738-42. View abstract.
Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. View abstract.
Chen QH, Yang Y, He HL, Xie JF, Cai SX, Liu AR, Wang HL, Qiu HB. The effect of glutamine therapy on outcomes in critically ill patients: a meta-analysis of randomized controlled trials. Crit Care. 2014 Jan 9;18(1):R8. View abstract.
Chuntrasakul C, Siltharm S, Sarasombath S, et al. Metabolic and immune effects of dietary arginine, glutamine and omega-3 fatty acids supplementation in immunocompromised patients. J Med Assoc Thai 1998;81:334-43.. View abstract.
Clark RH, Feleke G, Din M, et al. Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study. JPEN J Parenter Enteral Nutr 2000;24:133-9. View abstract.
Clark RH, Feleke G, Din M, et al. Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study. JPEN J Parenter Enteral Nutr 2000;24:133-9.. View abstract.
Cockerham MB, Weinberger BB, Lerchie SB. Oral glutamine for the prevention of oral mucositis associated with high-dose paclitaxel and melphalan for autologous bone marrow transplantation. Ann Pharmacother 2000;34:300-3.. View abstract.
Coghlin Dickson TM, Wong RM, Negrin RS, et al. Effect of oral glutamine supplementation during bone marrow transplantation. JPEN J Parenter Enteral Nutr 2000;24:61-6.. View abstract.
Daniele B, Perrone F, Gallo C, et al. Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial. Gut 2001;48:28-33.. View abstract.
Decker-Baumann C, Buhl K, Frohmuller S, et al. Reduction of chemotherapy-induced side-effects by parenteral glutamine supplementation in patients with metastatic colorectal cancer. Eur J Cancer 1999;35:202-7.. View abstract.
Den Hond E, Hiele M, Peeters M, et al. Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn's disease. J Parenter Enteral Nutr 1999;23:7-11. View abstract.
Eschbach LF, Webster MJ, Boyd JC, et al. The effect of siberian ginseng (Eleutherococcus senticosus) on substrate utilization and performance. Int J Sport Nutr Exerc Metab 2000;10:444-51. View abstract.
FDA. List of orphan designations and approvals. Office of Orphan Products Development. Available at: www.fda.gov/orphan/designat/list.htm.
Furst P. New developments in glutamine delivery. J Nutr 2001;131:2562S-8S.. View abstract.
Furukawa S, Saito H, Inoue T, et al. Supplemental glutamine augments phagocytosis and reactive oxygen intermediate production by neutrophils and monocytes from postoperative patients in vitro. Nutrition 2000;16:323-9.. View abstract.
Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. View abstract.
Griffiths RD. Glutamine: establishing clinical indications. Curr Opin Clin Nutr Metab Care 1999;2:177-82.. View abstract.
Haub MD, Potteiger JA, Nau KL, et al. Acute L-glutamine ingestion does not improve maximal effort exercise. J Sports Med Phys Fitness 1998;38:240-4. View abstract.
Holecek M. Relation between glutamine, branched-chain amino acids, and protein metabolism. Nutrition 2002;18:130-3.. View abstract.
Houdijk AP, Rijnsburger ER, Jansen J, et al. Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet 1998;352:772-6.. View abstract.
Jebb SA, Osborne RJ, Maughan TS, et al. 5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation. Br J Cancer 1994;70:732-5.. View abstract.
Jian ZM, Cao JD, Zhu XG, et al. The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients. JPEN J Parenter Enteral Nutr 1999;23:S62-6.. View abstract.
Jones C, Palmer TE, Griffiths RD. Randomized clinical outcome study of critically ill patients given glutamine-supplemented enteral nutrition. Nutrition 1999;15:108-15.. View abstract.
Khogali SE, Pringle SD, Weryk BV, Rennie MJ. Is glutamine beneficial in ischemic heart disease? Nutrition 2002;18:123-6.. View abstract.
Kusumoto I. Industrial production of L-glutamine. J Nutr 2001;131:2552S-5S.. View abstract.
Lacey JM, Wilmore DW. Is Glutamine a Conditionally Essential Amino Acid? Nutr Rev. 1990;48(8):297-309. View abstract.
Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. View abstract.
Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
Medina MA. Glutamine and cancer. J Nutr 2001;131:2539S-42S.. View abstract.
Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. View abstract.
Mertes N, Schulzki C, Goeters C, et al. Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study. Clin Nutr 2000;19:395-401.. View abstract.
Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48.. View abstract.
Moe-Byrne T, Wagner JV, McGuire W. Glutamine supplementation to prevent morbidity and mortality in preterm infants. Cochrane Database Syst Rev. 2012 Mar 14;3:CD001457. View abstract.
Morlion BJ, Stehle P, Wachtler P, et al. Total parenteral nutrition with glutamine dipeptide after major abdominal surgery: a randomized, double-blind, controlled study. Ann Surg 1998;227:302-8.. View abstract.
Neu J. Glutamine in the fetus and critically ill low birth weight neonate: metabolism and mechanism of action. J Nutr 2001;131:2585S-9S.. View abstract.
Newsholme P. Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection? J Nutr 2001;131:2515S-22S.. View abstract.
Niihara Y, Zerez CR, Akiyama DS, et al. Oral L-glutamine therapy for sickle cell anemia: I. Subjective clinical improvement and favorable change in red cell NAD redox potential. Am J Hematol 1998;58:117-21. View abstract.
Noyer CM, Simon D, Borczuk A, et al. A double-blind placebo-controlled pilot study of glutamine therapy for abnormal intestinal permeability in patients with AIDS. Am J Gastroenterol 1998;93:972-5. View abstract.
Noyer CM, Simon D, Borczuk A, et al. A double-blind placebo-controlled pilot study of glutamine therapy for abnormal intestinal permeability in patients with AIDS. Am J Gastroenterol 1998;93:972-5.. View abstract.
Okuno SH, Woodhouse CO, Loprinzi CL, et al. Phase III controlled evaluation of glutamine for decreasing stomatitis in patients receiving fluorouracil (5-FU)-based chemotherapy. Am J Clin Oncol 1999;22:258-61. View abstract.
Powell-Tuck J, Jamieson CP, Bettany GE, et al. A double blind, randomised, controlled trial of glutamine supplementation in parenteral nutrition. Gut 1999;45:82-8.. View abstract.
Rachkauskas GS. The efficacy of enterosorption and a combination of antioxidants in schizophrenics. Lik Sprava 1998;4:122-4. View abstract.
Reeds PJ, Burrin DG. Glutamine and the bowel. J Nutr 2001;131:2505S-8S.. View abstract.
Rees C, Oppong K, Mardini H, et al. Effect of L-Ornithine-L-Aspartate on patients with and without TIPS undergoing glutamine challenge: a double blind, placebo controlled trial. Gut 2000;47:571-4.. View abstract.
Ribeiro Junior H, Ribeiro T, Mattos A, et al. Treatment of acute diarrhea with oral rehydration solutions containing glutamine. J Am Coll Nutr 1994;13:251-5.. View abstract.
Robert G. Petit II, Chris French. Phase III Clinical Trial Design Considerations for Oral Treatments of Chemotherapy-Induced Mucositis: AES-14 (Uptake-Facilitated L-Glutamine) Pivotal Studies. 2001 ASCO Annual Meeting. Abstract #2954. Available at: http://www.asco.org/ac/1,1003,_12-002636-00_18-0010-00_19-002954,00.asp.
Rohde T, Asp S, MacLean DA, Pedersen BK. Competitive sustained exercise in humans, lymphokine activated killer cell activity, and glutamine--an intervention study. Eur J Appl Physiol Occup Physiol 1998;78:448-53.. View abstract.
Rohde T, MacLean DA, Pedersen BK. Effect of glutamine supplementation on changes in the immune system induced by repeated exercise. Med Sci Sports Exerc 1998;30:856-62.. View abstract.
Rubio IT, Cao Y, Hutchins LF, et al. Effect of glutamine on methotrexate efficacy and toxicity. Ann Surg 1998;227:772-8.. View abstract.
Sacks GS. Glutamine supplementation in catabolic patients. Ann Pharmacother 1999;33:348-54.. View abstract.
Savarese D, Al-Zoubi A, Boucher J. Glutamine for irinotecan diarrhea. J Clin Oncol 2000;18:450-1.
Savarese D, Boucher J, Corey B, et al. Glutamine treatment of paclitaxel-induced myalgias and arthralgias [letter]. J Clin Oncol 1998;16:3918-9.
Schloerb PR, Skikne BS. Oral and parenteral glutamine in bone marrow transplantation: a randomized, double-blind study. JPEN J Parenter Enteral Nutr 1999;23:117-22.. View abstract.
Scolapio JS, Camilleri M, Fleming CR, et al. Effect of growth hormone, glutamine, and diet on adaptation in short-bowel syndrome: a randomized, controlled study. Gastroenterology 1997;113:1074-81. View abstract.
Scolapio JS, McGreevy K, Tennyson GS, Burnett OL. Effect of glutamine in short-bowel syndrome. Clin Nutr 2001;20:319-23.. View abstract.
Scolapio JS. Effect of growth hormone, glutamine, and diet on body composition in short bowel syndrome: a randomized, controlled study. JPEN J Parenter Enteral Nutr 1999;23:309-12.. View abstract.
Shabert JK, Winslow C, Lacey JM, Wilmore DW. Glutamine-antioxidant supplementation increases body cell mass in AIDS patients with weight loss: a randomized, double-blind controlled trial. Nutrition 1999;15:860-4.
Shabert JK, Winslow C, Lacey JM, Wilmore DW. Glutamine-antioxidant supplementation increases body cell mass in AIDS patients with weight loss: a randomized, double-blind controlled trial. Nutrition 1999;15:860-4.. View abstract.
Skubitz KM, Anderson PM. Oral glutamine to prevent chemotherapy induced stomatitis: a pilot study. J Lab Clin Med 1996;127:223-8.. View abstract.
Szkudlarek J, Jeppesen PB, Mortensen PB. Effect of high dose growth hormone with glutamine and no change in diet on intestinal absorption in short bowel patients: a randomised, double blind, crossover, placebo controlled study. Gut 2000;47:199-205.. View abstract.
Tao KM, Li XQ, Yang LQ, Yu WF, Lu ZJ, Sun YM, Wu FX. Glutamine supplementation for critically ill adults. Cochrane Database Syst Rev. 2014 Sep 9;9:CD010050. View abstract.
Umpleby AM, Carroll PV, Russell-Jones DL, et al. Glutamine supplementation and GH/IGF-I treatment in critically ill patients: effects on glutamine metabolism and protein balance. Nutrition 2002;18:127-9.. View abstract.
Van Den Berg CJ, Jones JD, Wilson DM, et al. Glutamine therapy of cystinuria. Invest Urol 1980;18:155-7. View abstract.
van der Hulst RR, van Kreel BK, von Meyenfeldt MF, et al. Glutamine and the preservation of gut integrity. Lancet 1993;341:1363-5.. View abstract.
van Zaanen HC, van der Lelie H, Timmer JG, et al. Parenteral glutamine dipeptide supplementation does not ameliorate chemotherapy-induced toxicity. Cancer 1994;74:2879-84.. View abstract.
Vierck JL, Icenoggle DL, Bucci L, Dodson MV. The effects of ergogenic compounds on myogenic satellite cells. Med Sci Sports Exerc 2003;35:769-76. View abstract.
Walsh NP, Blannin AK, Robson PJ, Gleeson M. Glutamine, exercise and immune function. Links and possible mechanisms. Sports Med 1998;26:177-91.. View abstract.
Ward E, Picton S, Reid U, et al. Oral glutamine in paediatric oncology patients: a dose finding study. Eur J Clin Nutr 2003;57:31-6. View abstract.
Wilmore DW, Schloerb PR, Ziegler TR. Glutamine in the support of patients following bone marrow transplantation. Curr Opin Clin Nutr Metab Care 1999;2:323-7.. View abstract.
Wilmore DW. The effect of glutamine supplementation in patients following elective surgery and accidental injury. J Nutr 2001;131:2543S-9S.. View abstract.
Yoshida S, Matsui M, Shirouzu Y, et al. Effects of glutamine supplements and radiochemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer. Ann Surg 1998;227:485-91.. View abstract.
Ziegler TR, Bazargan N, Galloway JR. Glutamine supplemented nutrition support: saving nitrogen and saving money? Clin Nutr 2000;19:375-7.
Ziegler TR, Bye RL, Persinger RL, et al. Effects of glutamine supplementation on circulating lymphocytes after bone marrow transplantation: a pilot study. Am J Med Sci 1998;315:4-10.. View abstract.
Ziegler TR, Young LS, Benfell K, et al. Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition after bone marrow transplantation. A randomized, double-blind, controlled study. Ann Intern Med 1992;116:821-8.. View abstract.
Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. View abstract.
Zoli G, Care M, Falco F, et al. Effect of oral glutamine on intestinal permeability and nutritional status in Crohn's disease [abstract]. Gastroenterology 1995;108:A766.