What Is Glutathione and How Does It Work?

Glutathione is an herbal supplement which can be used for treatment in male infertility (intramuscular use), plaque deposits in the arteries (atherosclerosis [intravenous, oral use]), cancers, chemotherapy adjunct (intramuscular, intravenous use), immunostimulant, liver diseases, lung diseases (inhaled use), memory loss, and Parkinson's disease (intravenous, oral use).

  • Glutathione is possibly effective for chemotherapy toxicity.
  • Glutathione is available under the following different brand names: Gamma-L-glutamyl-L-cysteinylglycine, GSH, L-glutathione, N-(N-L-gamma-glutamyl-L-cysteinyl) glycine.

What Are Dosages of Glutathione?

Dosages of Glutathione:

  • Intravenously

Dosage Considerations – Should be Given as Follows:

Chemotherapy Adjunct

  • 600 mg/day intramuscularly days 2-5 of chemotherapy
  • 1.5 g/m2 intravenously before chemotherapy

Male Infertility

  • 600 mg intramuscularly every other day for two months


  • 250 mg orally once daily
  • Dose range: 50-600 mg/day


What Are Side Effects Associated with Using Glutathione?

Common side effects of Glutathione include:

  • difficulty breathing (inhaled use)

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Glutathione?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Glutathione has no known severe interactions with other drugs.
  • Glutathione has no known serious interactions with other drugs.
  • Glutathione has no known moderate interactions with other drugs.
  • Glutathione has mild interactions with at least 89 different drugs.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns, or for more information about this medicine.

What Are Warnings and Precautions for Glutathione?


  • No information available
  • This medication contains glutathione. Do not take Gamma-L-glutamyl-L-cysteinyl glycine, GSH, L-glutathione, or N-(N-L-gamma-glutamyl-L-cysteinyl) glycine. If you are allergic to glutathione or any ingredients contained in this drug
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately


Effects of Drug Abuse

  • No information provided

Short-Term Effects

  • See "What Are Side Effects Associated with Using Glutathione?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Glutathione?"


  • No information available

Pregnancy and Lactation

  • Avoid the use of glutathione during pregnancy
  • Avoid the use of glutathione when breastfeeding
Medscape. Glutathione.
RxList. Glutathione. Side Effects Center.

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