Reviewed on 6/11/2021
Other Name(s):

Ambrotose, Gluconutrientes, Manapol.


Glyconutrients are plant sugars linked in chains. The body breaks down these sugar chains into simple sugars. The most commonly used glyconutrients contain plant sugars from aloe and larch arabinogalactan. People use these sugars to make medicine.

Glyconutrients are taken by mouth for alcoholism, allergy, Alzheimer's disease, amyotrophic lateral sclerosis, (ALS, Lou Gehrig's disease), asthma, the buildup of plaque in the arteries (atherosclerosis), athletic performance, attention deficit-hyperactivity disorder (ADHD), autism, cancer, cerebral palsy, chronic fatigue syndrome, mental function, common cold, Crohn's disease, cystic fibrosis, depression, Down's syndrome, dyslexia, fibromyalgia, growth problems in infants, hepatitis, HIV/AIDS, Huntington's disease, fertility problems, flu, lupus, vision loss (macular degeneration), multiple sclerosis, a condition that causes loss of muscle (muscular dystrophy), a nerve condition that causes muscle weakness and tiredness (myasthenia gravis), Parkinson's disease, arthritis, stroke, Tay-Sachs disease, and Tourette's syndrome.

Glyconutrients are applied to the skin for mouth sores (canker sores), fever blisters, and dental diseases.

How does it work?

Glyconutrients might stimulate the immune system or promote the growth of certain bacteria in the colon that are thought to be beneficial.


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Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

  • Attention deficit-hyperactivity disorder (ADHD).
  • Early research shows that taking a glyconutrient supplement for 3 weeks reduces the number and severity of ADHD symptoms and improves conduct in children with ADHD. However, taking the glyconutrient supplement for 3 more weeks in combination with a plant-based supplement plus fruits and vegetables does not improve symptoms any more.
  • Mental function.
  • Some early research shows that taking a glyconutrient supplement (Ambrotose Complex, Mannatech Inc.) for 12 weeks improves some parts of memory in middle-aged people. But taking a single glyconutrient supplement does not seem to improve memory in these people. However, taking a single dose of a glyconutrient supplement (Ambrotose Complex, Mannatech Inc.) might improve mental function in some college students.
  • Growth problems in infants.
  • Early research shows that taking glyconutrients (Ambrotose Complex, Mannatech Inc.) for one month improves height and weight in young children whose weight is low for their age.
  • Mental well-being.
  • Early research shows that taking a glyconutrient supplement (Ambrotose Complex, Mannatech Inc.) for 12 weeks improves parts of mental well-being, such as energy, calmness, sleep quality, and concentration, in middle-aged people.
  • Allergy.
  • Alzheimer's disease.
  • Amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease).
  • Asthma.
  • Buildup of plaque in the arteries (atherosclerosis).
  • Athletic performance.
  • Autism.
  • Cancer.
  • Cerebral palsy.
  • Chronic fatigue syndrome.
  • Common cold.
  • Crohn's disease.
  • Cystic fibrosis.
  • Depression.
  • Down's syndrome.
  • Dyslexia.
  • Fibromyalgia.
  • Hepatitis.
  • Huntington's disease.
  • Fertility problems.
  • Flu.
  • Lupus.
  • Vision loss (macular degeneration).
  • Multiple sclerosis.
  • A condition that causes loss of muscle (muscular dystrophy).
  • A nerve condition that causes weakness and tiredness (myasthenia gravis).
  • Parkinson's disease.
  • Arthritis.
  • Stroke.
  • Tay-Sachs disease.
  • Tourette's syndrome.
  • Mouth sores.
  • Dental diseases.
  • Other conditions.
More evidence is needed to rate the effectiveness of glyconutrients for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Side Effects

Glyconutrients are POSSIBLY SAFE when taken by mouth in a dose of about 9 grams per day for 7 weeks. They can cause intestinal gas (flatulence), bloating, and thirst.


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Special Precautions & Warnings

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking glyconutrients if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

"Auto-immune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Glyconutrients might cause the immune system to become more active. This might increase the symptoms of auto-immune diseases. If you have an auto-immune condition, it's best to avoid using glyconutrients as medicine until more is known.


Medications that decrease the immune system (Immunosuppressants)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Glyconutrients might make the immune system more active. Taking glyconutrients along with medications that decrease the immune system might decrease the effectiveness of these medications.

Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids).


The appropriate dose of glyconutrients depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for glyconutrients. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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