Last updated on RxList: 1/26/2021
Glydo Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Glydo?

Glydo (lidocaine HCl jelly, 2%) contains a local anesthetic agent used to prevent and control pain in procedures involving the male and female urethra, for topical treatment of painful urethritis, and as an anesthetic lubricant for endotracheal intubation (oral and nasal). Glydo is available as a generic.

What Are Side Effects of Glydo?

Side effects of Glydo include:

Dosage for Glydo

Dosing depends on the procedure being performed.

Glydo In Children

Although the safety and effectiveness of Glydo in pediatric patients has not been established, dosages in children should be reduced, commensurate with age, body weight, and physical condition.

What Drugs, Substances, or Supplements Interact with Glydo?

Glydo may interact with other medicines such as:

  • nitrates/nitrites,
  • local anesthetics,
  • cancer drugs,
  • antibiotics,
  • anti-malaria drugs,
  • anticonvulsants,
  • acetaminophen,
  • metoclopramide,
  • quinine, and
  • sulfasalazine

Tell your doctor all medications and supplements you use.

Glydo During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Glydo; it is unknown how it would affect a fetus. Glydo passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Glydo (lidocaine HCl jelly, 2%) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Glydo Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe burning, stinging, or irritation where the medicine was applied;
  • swelling or redness;
  • sudden dizziness or drowsiness after medicine is applied;
  • confusion, blurred vision, ringing in your ears; or
  • unusual sensations of temperature.

Common side effects include:

  • mild irritation where the medication is applied; or
  • numbness in places where the medicine is accidentally applied.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Glydo (Lidocaine HCI Jelly USP, 2%)


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Glydo Professional Information


Adverse experiences following the administration of lidocaine are similar in nature to those observed with other amide local anesthetic agents. These adverse experiences are, in general, dose-related and may result from high plasma levels caused by excessive dosage or rapid absorption, or may result from a hypersensitivity, idiosyncrasy, or diminished tolerance on the part of the patient. Serious adverse experiences are generally systemic in nature. The following types are those most commonly reported:

There have been rare reports of endotracheal tube occlusion associated with the presence of dried jelly residue in the inner lumen of the tube (see WARNINGS and DOSAGE AND ADMINISTRATION).

Central Nervous System

CNS manifestations are excitatory and/or depressant and may be characterized by lightheadedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, vomiting, sensations of heat, cold or numbness, twitching, tremors, convulsions, unconsciousness, respiratory depression, and arrest. The excitatory manifestations may be very brief or may not occur at all, in which case the first manifestation of toxicity may be drowsiness merging into unconsciousness and respiratory arrest.

Drowsiness following the administration of lidocaine is usually an early sign of a high blood level of the drug and may occur as a consequence of rapid absorption.

Cardiovascular System

Cardiovascular manifestations are usually depressant and are characterized by bradycardia, hypotension, and cardiovascular collapse, which may lead to cardiac arrest.


Allergic reactions are characterized by cutaneous lesions, urticaria, edema, or anaphylactoid reactions. Allergic reactions may occur as a result of sensitivity either to the local anesthetic agent or to other components in the formulation. Allergic reactions as a result of sensitivity to lidocaine are extremely rare and, if they occur, should be managed by conventional means. The detection of sensitivity by skin testing is of doubtful value.

To report SUSPECTED ADVERSE REACTIONS, contact Sagent Pharmaceuticals, Inc. at 1 -8 6 6 -6 2 5 -1 6 1 8 or FDA at 1-800-FDA-1088 or

Read the entire FDA prescribing information for Glydo (Lidocaine HCI Jelly USP, 2%)

© Glydo Patient Information is supplied by Cerner Multum, Inc. and Glydo Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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