Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 5/12/2022
GLYRX-PF Side Effects Center


GLYRX-PF (glycopyrrolate injection) is an anticholinergic indicated in anesthesia (adult and pediatric patients); for reduction of airway or gastric secretions, and volume and acidity of gastric secretions, and blockade of cardiac inhibitory reflexes during induction of anesthesia and intubation; intraoperatively to counteract surgically or drug-induced or vagal reflex-associated arrhythmias; and for protection against peripheral muscarinic effects of cholinergic agents. GLYRX-PF is also used) as adjunctive therapy for the treatment of peptic ulcer when rapid anticholinergic effect is desired or oral medication is not tolerated.

What Are Side Effects of GLYRX-PF?

Common side effects of GLYRX-PF include:

  • dry mouth,
  • urinary hesitancy and retention;
  • blurred vision and sensitivity to light due to dilated pupils,
  • vision problems,
  • increased eye pressure,
  • fast or slow heart rate,
  • palpitations, and
  • decreased sweating

Dosage for GLYRX-PF

GLYRX-PF may be administered intramuscularly (IM), or intravenously (IV), with or without dilution. The dosage and regimen of GLYRX-PF depends on the condition being treated.

What Drugs, Substances, or Supplements Interact with GLYRX-PF?

GLYRX-PF may interact with other anticholinergics or medications with anticholinergic activity, such as phenothiazines, antiparkinson drugs, or tricyclic antidepressants. Tell your doctor all medications and supplements you use.

GLYRX-PF During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using GLYRX-PF; it is unknown how it would affect a fetus. It is unknown if GLYRX-PF passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our GLYRX-PF (glycopyrrolate injection), for Intravenous or Intramuscular Use Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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GLYRX-PF Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using glycopyrrolate and call your doctor at once if you have:

  • severe constipation, severe stomach pain and bloating;
  • diarrhea (especially if you have a colostomy or ileostomy);
  • painful or difficult urination;
  • fast or pounding heartbeats, fluttering in your chest;
  • confusion, severe drowsiness;
  • eye pain, seeing halos around lights;
  • fever, shallow breathing, weak pulse, hot and red skin; or
  • (in a child taking glycopyrrolate) dry diapers, fussiness, or excessive crying.

Common side effects may include:

  • constipation, nausea, vomiting, bloating;
  • drowsiness, dizziness, weakness, feeling nervous;
  • slow heartbeats;
  • sleep problems (insomnia);
  • blurred vision, sensitivity to light;
  • dry mouth, decreased sense of taste;
  • decreased sweating, decreased urination;
  • impotence, sexual problems;
  • headache; or
  • rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for GLYRX-PF (Glycopyrrolate Injection)


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GLYRX-PF Professional Information


The following adverse reactions were identified in clinical studies or postmarketing reports. Because some of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Adverse reactions to anticholinergics include xerostomia (dry mouth); urinary hesitancy and retention; blurred vision and photophobia due to mydriasis (dilation of the pupil); cycloplegia; increased ocular tension; tachycardia; palpitation; decreased sweating; loss of taste; headache; nervousness; drowsiness; weakness; dizziness; insomnia; nausea; vomiting; impotence; suppression of lactation; constipation; bloated feeling; severe allergic reactions including anaphylactic/anaphylactoid reactions; hypersensitivity; urticaria, pruritus, dry skin, and other dermal manifestations; some degree of mental confusion and/or excitement, especially in elderly persons.

The following adverse reactions have been reported from post-marketing experience with glycopyrrolate: malignant hyperthermia; cardiac arrhythmias (including bradycardia, ventricular tachycardia, ventricular fibrillation); cardiac arrest; hypertension; hypotension; seizures; and respiratory arrest. Post-marketing reports have included cases of heart block and QTc interval prolongation associated with the combined use of glycopyrrolate and an anticholinesterase. Injection site reactions including pruritus, edema, erythema, and pain have also been reported.

Read the entire FDA prescribing information for GLYRX-PF (Glycopyrrolate Injection)

© GLYRX-PF Patient Information is supplied by Cerner Multum, Inc. and GLYRX-PF Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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