- What other names is Goat's Rue known by?
- What is Goat's Rue?
- How does Goat's Rue work?
- Are there safety concerns?
- Are there any interactions with medications?
- Dosing considerations for Goat's Rue.
Faux-Indigo, French Honeysuckle, French Lilac, Galega, Galéga, Galéga Officinal, Galega bicolor, Galega officinalis, Galega patula, Galegae Officinalis Herba, Geissrautenkraut, Goat's Rue Herb, Italian Fitch, Lavanèse, Lilas d'Espagne, Lilas Français, Rue-de-Chèvre, Rue des Chèvres, Sainfoin d'Espagne.
Goat's rue is a plant. The parts that grow above the ground are used to make medicine. Be careful not to confuse goat's rue (Galega officinalis) with rue (Ruta graveolens).
In combination with other herbs, goat's rue is used to stimulate the adrenal gland and pancreas; to protect the liver; for digestion problems; and to start the flow of breast milk. Some people use herbal combinations that include goat's rue as a tonic and for “blood purification.”
Insufficient Evidence to Rate Effectiveness for...
- “Blood purification.”
- Digestive problems.
- Other uses.
There isn't enough information to know whether goat's rue is safe. No harmful effects have been reported in humans, but fatal poisoning has occurred in grazing animals that ate large quantities of goat's rue.
Special Precautions & Warnings:Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking goat's rue if you are pregnant or breast-feeding. Stay on the safe side and avoid use.
Bleeding conditions: Goat's rue might slow blood clotting and increase the risk of bleeding. In theory, goat's rue might make bleeding disorders worse.
Surgery: Goat's rue might affect blood sugar levels. There is concern that it might interfere with blood sugar control during and after surgery. Stop using goat's rue at least 2 weeks before a scheduled surgery.
Medications for diabetes (Antidiabetes drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Goat's rue might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking goat's rue along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Goat's rue might slow blood clotting. Taking goat's rue along with medications that also slow blood clotting might increase the chances of bruising and bleeding.
The appropriate dose of goat's rue depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for goat's rue. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Health Solutions From Our Sponsors
Atanasov, A. T. and Spasov, V. Inhibiting and disaggregating effect of gel-filtered Galega officinalis L. herbal extract on platelet aggregation. J.Ethnopharmacol. 2000;69(3):235-240. View abstract.
Atanasov, A. T. and Spasov, V. Inhibiting effect of desalted extract from Galega officinalis L. on platelet aggregation. Folia Med.(Plovdiv.) 1999;41(1):46-50. View abstract.
Atanasov, A. T. and Tchorbanov, B. Anti-platelet fraction from Galega officinalis L. inhibits platelet aggregation. J.Med.Food 2002;5(4):229-234. View abstract.
Atanasov, A. T. and Tchorbanov, B. J. Antiplatelet aggregation activity of a fraction isolated from Galega officinalis L. J Herbs Spices Medicinal Plant 2002;10(2):63-71.
Atanasov, A. T. Effect of Galega officinalis L. extract on platelet aggregation in rats. J Herbs Spices Medicinal Plant 1995;3:71-76.
Atanasov, A. T., Chorbanov, B. P., and Dimitrov, B. D. Anti-aggregation activity of crude water extract of Galega officinalis L. fractionated on Sephadex G-25 and Sepharose 4B. Folia Med.(Plovdiv.) 2002;44(1-2):45-49. View abstract.
Bailey, C. J. and Day, C. Metformin: its botanical background. Pract Diab Int 2004;21(3):115-117.
Barger, G. and White, F. D. Galuteolin, a New Glucoside from Galega Officinalis. Biochem.J 1923;17(6):836-838. View abstract.
Cavaliere, C. Glucophage: Diabetic drug based on traditional herb celebrates 50 years of use. HerbalGram 2008;76:44-49.
Champavier, Y., Allais, D. P., Chulia, A. J., and Kaouadji, M. Acetylated and non-acetylated flavonol triglycosides from Galega officinalis. Chem.Pharm Bull.(Tokyo) 2000;48(2):281-282. View abstract.
FERRARI, G. [New method of preparation of galegine from the seeds of Galega officinalis.]. Farmaco 1950;5(5):544-545. View abstract.
Gonzalez-Andres, F., Redondo, P. A., Pescador, R., and Urbano, B. Management of Galega officinalis L. and preliminary results on its potential for milk production improvement in sheep. New Zealand Journal of Agricultural Research 2004;47:233-245.
Hadden, D. R. Goat's rue - French lilac - Italian fitch - Spanish sainfoin: gallega officinalis and metformin: the Edinburgh connection. J R.Coll.Physicians Edinb. 2005;35(3):258-260. View abstract.
Keeler, R. F., Baker, D. C., and Evans, J. O. Individual animal susceptibility and its relationship to induced adaptation or tolerance in sheep to Galega officinalis L. Vet.Hum.Toxicol. 1988;30(5):420-423. View abstract.
Keeler, R. F., Baker, D. C., and Panter, K. E. Concentration of galegine in Verbesina encelioides and Galega oficinalis and the toxic and pathologic effects induced by the plants. J Environ.Pathol.Toxicol.Oncol. 1992;11(2):11-17. View abstract.
Keeler, R. F., Johnson, A. E., Stuart, L. D., and Evans, J. O. Toxicosis from and possible adaptation to Galega officinalis in sheep and the relationship to Verbesina encelioides toxicosis. Vet.Hum.Toxicol. 1986;28(4):309-315. View abstract.
LAPYNINA, L. A. [ON FLAVONOID COMPOSITION OF GALEGA OFFICINALIS.]. Farm.Zh. 1965;20:57-62. View abstract.
Misbin, R. I. The phantom of lactic acidosis due to metformin in patients with diabetes. Diabetes Care 2004;27(7):1791-1793. View abstract.
Mooney, M. H., Fogarty, S., Stevenson, C., Gallagher, A. M., Palit, P., Hawley, S. A., Hardie, D. G., Coxon, G. D., Waigh, R. D., Tate, R. J., Harvey, A. L., and Furman, B. L. Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice. Br.J Pharmacol. 2008;153(8):1669-1677. View abstract.
Neef, H., Augustijns, P., Declercq, P., Declerck, P. J., and Laekeman, G. Inhibitory effects of Galega officinalis on glucose transport across monolayers of human intestinal epithelial cells. Pharmaceutical and Pharmacological Letters 1996;6:86-89.
Palit, P., Furman, B. L., and Gray, A. I. Novel weight-reducing activity of Galega officinalis in mice. J Pharm Pharmacol. 1999;51(11):1313-1319. View abstract.
Petricic, J. and Kalodera, Z. Galegin in the goat's rue herb: toxicity, antidiabetic activity and content determination. Acta Pharm Jugosl 1982;32:219-223.
PUFAHL, K. and SCHREIBER, K. [Isolation of a new guanidine derivative from goat's rue, Galega officinalis L.]. Experientia 7-15-1961;17:302-303. View abstract.
Pundarikakshudu, K., Patel, J. K., Bodar, M. S., and Deans, S. G. Anti-bacterial activity of Galega officinalis L. (Goat's Rue). J Ethnopharmacol. 2001;77(1):111-112. View abstract.
Puyt, J. D., Faliu, L., Keck, G., Gedfrain, J. C., Pinault, L., and Tainturier, D. Fatal poisoning of sheep by Galega officinalis (French honeysuckle). Vet.Hum.Toxicol. 1981;23(6):410-412. View abstract.
Rasekh, H. R., Nazari, P., Kamli-Nejad, M., and Hosseinzadeh, L. Acute and subchronic oral toxicity of Galega officinalis in rats. J Ethnopharmacol. 2-28-2008;116(1):21-26. View abstract.
Reuter, G. [ARGININE AS THE FIRST STAGE OF GALEGINE IN GALEGA OFFICINALIS L. ON THE BIOCHEMISTRY AND PHYSIOLOGY OF GALEGINE IN GALEGA OFFICINALIS L. III.]. Arch.Pharm (Weinheim) 1963;296:516-522. View abstract.
Reuter, G. and Barthel, A. [Guanidino-acetic acid as precursor of galegin in Galega officinalis L]. Pharmazie 1967;22(5):261. View abstract.
Reuter, G., Barthel, A., and Steiniger, J. [Metabolism of guanidine acetic acid in Galega officinalis L]. Pharmazie 1969;24(6):358. View abstract.
Schafer, J. and Stein, M. [On the variability of substances contained in the goat's rue (Galega officinalis L.)]. Naturwissenschaften 1967;54(8):205. View abstract.
SCHREIBER, K., AURICH, O., and PUFAHL, K. [Isolation of peganine from goat's-rue, Galega officinalis L.]. Arch.Pharm 1962;295/67:271-275. View abstract.
Vuksan, V. and Sievenpiper, J. L. Herbal remedies in the management of diabetes: lessons learned from the study of ginseng. Nutr.Metab Cardiovasc.Dis. 2005;15(3):149-160. View abstract.
Atanasov AT. Effect of Galega officinalis L. extract on platelet aggregation in rats. J Herbs Spices Med Plants 1995;3:71-6.
Huxtable CR, Dorling RR, Colegate SM. Identification of galegine, an isoprenyl guanidine, as the toxic principle of Schoenus asperocarpus (poison sedge). Aust Vet J 1993;70:169-71. View abstract.
Lemus, I., Garcia, R., Delvillar, E., and Knop, G. Hypoglycaemic activity of four plants used in Chilean popular medicine. Phytother Res 1999;13(2):91-94. View abstract.
Neef H, Augustijns P, Declercq P, et al. Inhibitory effects of Galega officinalis on glucose transport across monolayers of human intestinal epithelial cells (Caco-2). Pharm Pharmacol Lett 1996;6:86-9.