GoLytely Side Effects Center

Last updated on RxList: 6/15/2021
GoLytely Side Effects Center

What Is GoLytely?

GoLytely (polyethylene glycol 3350 and electrolytes) Oral Solution is a combination of a laxative and electrolytes for bowel cleansing prior to colonoscopy and barium enema X-ray examination in adults. GoLytely is available in generic form.

What Are Side Effects of GoLytely?

Common side effects of GoLytely include:

  • nausea,
  • stomach or abdominal fullness,
  • bloating,
  • stomach or abdominal cramps,
  • vomiting, and
  • anal irritation

Dosage for GoLytely

GoLytely is a powder that must be reconstituted with water before use. One gallon reconstituted GoLytely solution contains doses of: 227.1 grams of polyethylene glycol (PEG) 3350, 21.5 grams sodium sulfate (anhydrous), 6.36 grams of sodium bicarbonate, 5.53 grams of sodium chloride, and 2.82 grams of potassium chloride.

What Drugs, Substances, or Supplements Interact with GoLytely?

GoLytely may interact with laxatives, and may affect the absorption of other drugs. Tell your doctor all medications and supplements you use.

GoLytely During Pregnancy or Breastfeeding

Consult your doctor before taking GoLytely if you are pregnant or breastfeeding.

Additional Information

Our GoLytely (polyethylene glycol 3350 and electrolytes) Oral Solution Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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GoLytely Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • no bowel movement within 2 hours after use;
  • vomiting;
  • dizziness, feeling like you might pass out;
  • little or no urination;
  • a seizure; or
  • signs of an electrolyte imbalance--increased thirst or urination, dry mouth, confusion, constipation, muscle pain or weakness, leg cramps, irregular heartbeats, tingly feeling.

You may need to drink the liquid more slowly, or stop using it for a short time if you have certain side effects. Call your doctor for instructions if you have:

  • gagging, choking, severe stomach pain or bloating;
  • nausea, vomiting, headache, trouble drinking liquids, little or no urinating; or
  • fever, sudden or severe stomach pain, severe diarrhea, rectal bleeding or bright red bowel movements.

Common side effects may include:

  • vomiting, stomach pain, indigestion, bloating;
  • rectal pain or irritation;
  • hunger, thirst, mild nausea;
  • trouble sleeping; or
  • dizziness, chills.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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GoLytely Professional Information


The following clinically significant adverse reactions are described elsewhere in the labeling:

  • Renal impairment [see WARNINGS AND PRECAUTIONS]
  • Colonic mucosal ulcerations and ischemic colitis [see WARNINGS AND PRECAUTIONS]
  • Patients with significant gastrointestinal disease [see WARNINGS AND PRECAUTIONS]

The following adverse reactions associated with the use of GoLYTELY were identified in clinical trials or postmarketing reports. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency, reliably, or establish a causal relationship to drug exposure.

  • Cardiovascular: arrhythmia, atrial fibrillation, peripheral edema, asystole, and acute pulmonary edema after aspiration [see WARNINGS AND PRECAUTIONS].
  • Nervous system: tremor, seizure [see WARNINGS AND PRECAUTIONS]
  • Hypersensitivity: Urticaria/rash, pruritus, dermatitis, rhinorrhea, dyspnea, chest and throat tightness, fever, angioedema, anaphylaxis and anaphylactic shock [see CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS]
  • Gastrointestinal: Nausea, abdominal fullness and bloating are the most common adverse reactions (occurred in up to 50% of patients). Other less common adverse reactions include: abdominal cramps, vomiting, “butterfly-like” infiltrates on chest X-ray after vomiting and aspirating PEG, anal irritation, and upper GI bleeding from Mallory-Weiss Tear, esophageal perforation [usually with gastroesophageal reflux disease (GERD)].


Drugs That May Increase Risks Due To Fluid And Electrolyte Abnormalities

Use caution when prescribing GoLYTELY for patients with conditions and/or who are using medications that increase the risk for fluid and electrolyte disturbances or may increase the risk of renal impairment, seizure, arrhythmias, and prolonged QT in the setting of fluid and electrolyte abnormalities [see WARNINGS AND PRECAUTIONS]. Consider additional patient evaluations as appropriate.

Potential For Reduced Drug Absorption

GoLYTELY can reduce the absorption of other administered drugs. Administer oral medications within one hour before the start of administration of GoLYTELY [see DOSAGE AND ADMINISTRATION].

Stimulant Laxatives

Concurrent use of stimulant laxatives and GoLYTELY may increase the risk of mucosal ulceration or ischemic colitis. Avoid use of stimulant laxatives (e.g., bisacodyl, sodium picosulfate) while taking GoLYTELY [see WARNINGS AND PRECAUTIONS].

Read the entire FDA prescribing information for GoLytely (Polyethylene Glycol 3350 and Electrolytes Oral Solution)

© GoLytely Patient Information is supplied by Cerner Multum, Inc. and GoLytely Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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