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How does Gossypol work?

Gossypol interferes with sperm development and function.

Are there safety concerns?

Gossypol is POSSIBLY UNSAFE for use without close supervision by a healthcare professional. When men take gossypol by mouth, the effects on sperm are unpredictable and might cause permanent inability to father a child (sterility) with long-term use. When women take gossypol by mouth, it might be toxic to cells lining the uterus and could prevent normal function of the ovaries.

Gossypol can also cause loss of energy, changes in appetite, decreased sexual desire (libido), changes in body potassium levels, and digestive tract problems. High doses of gossypol (100 times the dose used for birth control) can cause malnutrition, blood circulation problems, heart failure, changes in hair color, and other problems.

There isn't enough information to know whether gossypol is safe to use directly on the skin. It can cause a burning sensation.

Special Precautions & Warnings:

Pregnancy and breast-feeding: It's LIKELY UNSAFE to take gossypol if you are pregnant. It might cause a miscarriage. It is POSSIBLY UNSAFE to take gossypol if you are breast-feeding.

Low potassium levels (hypokalemia): Gossypol may make low potassium levels worse. Avoid using it if you have this condition.

Urinary tract irritation: Gossypol may make urinary tract irritation worse. Avoid using it if you have this condition.

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