Graft Versus Host Disease (GVHD): Symptoms & Signs

Medically Reviewed on 6/13/2020

Graft versus host disease (GVHD) is a condition that occurs in people who have received stem cell or organ transplants.

GVHD occurs in both acute and chronic (long-term) forms. Signs and symptoms of acute GVHD include

  • itchy, red skin,
  • rash,
  • nausea,
  • vomiting,
  • diarrhea, and
  • liver inflammation.

In chronic GVHD, the symptoms and signs can include

Causes of graft versus host disease (GVHD)

It is caused by a reaction in which immune cells present in donor tissue (the graft) attack the host's own tissues. GVHD is a complication after bone marrow transplantation (stem cell transplants) from both related and unrelated donors.

Other graft versus host disease symptoms and signs

Medically Reviewed by a Doctor on 6/13/2020


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