Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 8/31/2021
Gvoke Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Gvoke?

Gvoke (glucagon) Injection is an antihypoglycemic agent indicated for the treatment of severe hypoglycemia in pediatric and adult patients with diabetes ages 2 years and above.

What Are Side Effects of Gvoke?

Common side effects of Gvoke include:

  • nausea,
  • vomiting,
  • injection site reactions (swelling, discomfort),
  • headache,
  • abdominal pain,
  • hives, and
  • high or low blood sugar (hyperglycemia or hypoglycemia)

Dosage for Gvoke

The recommended dose of Gvoke for adults and pediatric patients aged 12 years and older is 1 mg. The recommended dose of Gvoke for pediatric patients aged 2 to under 12 years of age is weight dependent.

What Drugs, Substances, or Supplements Interact with Gvoke?

Gvoke may interact with beta-blockers, indomethacin, and warfarin. Tell your doctor all medications and supplements you use.

Gvoke During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Gvoke; it is not expected to be harmful to a fetus. It is unknown if Gvoke passes into breast milk, however, glucagon is a peptide and would be expected to be broken down to its constituent amino acids in the infant's digestive tract and is unlikely to cause harm to an exposed infant. Consult your doctor before breastfeeding.

Additional Information

Our Gvoke (glucagon) Injection, for Subcutaneous Use Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Gvoke Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; fast or slow heartbeat; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of the following skin changes on your face, legs, groin, or genital area:

  • redness;
  • itching;
  • blistering;
  • crusting, scaling; or
  • other skin sores or lesions.

Common side effects may include:

  • nausea, vomiting; or
  • swelling where an injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Gvoke (Glucagon Injection)


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Gvoke Professional Information


The following serious adverse reactions are described below and elsewhere in labeling:

  • Hypersensitivity and Allergic Reactions [ see WARNINGS AND PRECAUTIONS].
  • Necrolytic Migratory Erythema [ see WARNINGS AND PRECAUTIONS].

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of GVOKE cannot be directly compared to rates in the clinical trials of other drugs and may not reflect the rates observed in practice.

Adverse Reactions In Adult Patients

The safety of GVOKE was evaluated in two randomized, blinded, 2-way crossover studies conducted in adults with type 1 diabetes mellitus. In total, 154 patients received an injection of GVOKE [ see Clinical Studies].

The most common adverse reactions occurring in 2% or more of adult subjects treated with GVOKE during clinical trials are listed in Table 1.

Table 1: Adverse Reactions Occurring ≥ 2% in Adult Patients with Type 1 Diabetes Mellitus Treated with GVOKE

GVOKE 1 mg dose
(N= 154)
Injection site edema raised 1 mm or greater7%

Read the entire FDA prescribing information for Gvoke (Glucagon Injection)

© Gvoke Patient Information is supplied by Cerner Multum, Inc. and Gvoke Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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