Harvoni vs. Vosevi

Are Harvoni and Vosevi the Same Thing?

Harvoni (ledipasvir and sofosbuvir) and Vosevi (sofosbuvir, velpatasvir, and voxilaprevir) are combinations of antiviral agents used to treat chronic hepatitis C (CHC) genotype 1 infection.

Vosevi is also used to treat chronic hepatitis C infection in patients with genotype 2, 3, 4, 5, or 6 infection and have previously been treated with an HCV regimen containing an NS5A inhibitor; or genotype 1a or 3 infection and have previously been treated with an HCV regimen containing sofosbuvir without an NS5A inhibitor.

Side effects of Harvoni and Vosevi that are similar include fatigue, headache, nausea, diarrhea, insomnia, and weakness or lack of energy.

Side effects of Vosevi that are different from Harvoni include rash and depression.

Both Harvoni and Vosevi may interact with rifampin and St. John's wort.

Vosevi may also interact with carbamazepine, antacids, H2-receptor antgonists, proton pump inhibitors (PPIs), methotrexate, mitoxantrone, imatinib, irinotecan, lapatinib, rosuvastatin, sulfasalazine, topotecan, amiodarone, digoxin, dabigatran, phenytoin, phenobarbital, oxcarbazepine, rifabutin, rifapentine, antiretrovirals, HMG-CoA reductase inhibitors, and cyclosporine.

What Are Possible Side Effects of Harvoni?

Common side effects of Harvoni include:

  • fatigue,
  • headache,
  • nausea,
  • diarrhea,
  • insomnia, and
  • weakness.

What Are Possible Side Effects of Vosevi?

Common side effects of Vosevi include:

  • headache,
  • fatigue,
  • diarrhea,
  • nausea,
  • weakness or lack of energy,
  • insomnia,
  • rash, or
  • depression

What Is Harvoni?

Harvoni (ledipasvir and sofosbuvir) is a direct-acting antiviral agent used to treat chronic hepatitis C (CHC) genotype 1 infection in adults.

What Is Vosevi?

Vosevi may interact with St. John's wort, carbamazepine, antacids, H2-receptor antgonists, proton pump inhibitors (PPIs), methotrexate, mitoxantrone, imatinib, irinotecan, lapatinib, rosuvastatin, sulfasalazine, topotecan, amiodarone, digoxin, dabigatran, phenytoin, phenobarbital, oxcarbazepine, rifampin, rifabutin, rifapentine, antiretrovirals, HMG-CoA reductase inhibitors, and cyclosporine. Tell your doctor all medications and supplements you use.

QUESTION

Hepatitis C virus causes an infection of the ______________. See Answer

What Drugs Interact With Harvoni?

Harvoni may interact with rifampin, and St. John's wort. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plant to become pregnant before using Harvoni. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Vosevi?

Vosevi may interact with rifampin and other antimycobacterials, St. John's wort, carbamazepine and other anticonvulsants, antacids, H2-receptor antagonists, proton-pump inhibitors, antiarrhythmics, topotecan, HIV antiretrovirals, and HMG-CoA reductase inhibitors. Tell your doctor all medications and supplements you use. Vosevi is not recommended for use during pregnancy. It is also not recommended for men whose female partners are pregnant. It is unknown if Vosevi passes into breast milk. Consult your doctor before breastfeeding.

How Should Harvoni Be Taken?

Harvoni is a two-drug fixed-dose combination product that contains 90 mg of ledipasvir and 400 mg of sofosbuvir in a single tablet. The recommended dosage of Harvoni is one tablet taken orally once daily with or without food.

How Should Vosevi Be Taken?

All patients should be tested for evidence of current or prior HBV infection by measuring hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (anti-HBc) before initiating HCV treatment with Vosevi. The recommended dosage of Vosevi is one tablet (400 mg of sofosbuvir, 100 mg of velpatasvir, and 100 mg of voxilaprevir) taken orally once daily with food.

SLIDESHOW

Hepatitis: How Do You Get Hepatitis A, B, and C? See Slideshow
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References
Gilead. Harvoni Product Information.

www.harvoni.com/?

Gilead. Vosevi Prescribing Information.

www.vosevi.com/?

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