- Are Harvoni and Vosevi the Same Thing?
- What Are Possible Side Effects of Harvoni?
- What Are Possible Side Effects of Vosevi?
- What Is Harvoni?
- What Is Vosevi?
- What Drugs Interact with Harvoni?
- What Drugs Interact with Vosevi?
- How Should Harvoni Be Taken?
- How Should Vosevi Be Taken?
Are Harvoni and Vosevi the Same Thing?
Vosevi is also used to treat chronic hepatitis C infection in patients with genotype 2, 3, 4, 5, or 6 infection and have previously been treated with an HCV regimen containing an NS5A inhibitor; or genotype 1a or 3 infection and have previously been treated with an HCV regimen containing sofosbuvir without an NS5A inhibitor.
Both Harvoni and Vosevi may interact with rifampin and St. John's wort.
Vosevi may also interact with carbamazepine, antacids, H2-receptor antgonists, proton pump inhibitors (PPIs), methotrexate, mitoxantrone, imatinib, irinotecan, lapatinib, rosuvastatin, sulfasalazine, topotecan, amiodarone, digoxin, dabigatran, phenytoin, phenobarbital, oxcarbazepine, rifabutin, rifapentine, antiretrovirals, HMG-CoA reductase inhibitors, and cyclosporine.
What Are Possible Side Effects of Harvoni?
Common side effects of Harvoni include:
- insomnia, and
What Are Possible Side Effects of Vosevi?
Common side effects of Vosevi include:
- weakness or lack of energy,
- rash, or
What Is Harvoni?
Harvoni (ledipasvir and sofosbuvir) is a direct-acting antiviral agent used to treat chronic hepatitis C (CHC) genotype 1 infection in adults.
What Is Vosevi?
Vosevi may interact with St. John's wort, carbamazepine, antacids, H2-receptor antgonists, proton pump inhibitors (PPIs), methotrexate, mitoxantrone, imatinib, irinotecan, lapatinib, rosuvastatin, sulfasalazine, topotecan, amiodarone, digoxin, dabigatran, phenytoin, phenobarbital, oxcarbazepine, rifampin, rifabutin, rifapentine, antiretrovirals, HMG-CoA reductase inhibitors, and cyclosporine. Tell your doctor all medications and supplements you use.
What Drugs Interact With Harvoni?
Harvoni may interact with rifampin, and St. John's wort. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plant to become pregnant before using Harvoni. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
What Drugs Interact With Vosevi?
Vosevi may interact with rifampin and other antimycobacterials, St. John's wort, carbamazepine and other anticonvulsants, antacids, H2-receptor antagonists, proton-pump inhibitors, antiarrhythmics, topotecan, HIV antiretrovirals, and HMG-CoA reductase inhibitors. Tell your doctor all medications and supplements you use. Vosevi is not recommended for use during pregnancy. It is also not recommended for men whose female partners are pregnant. It is unknown if Vosevi passes into breast milk. Consult your doctor before breastfeeding.
How Should Harvoni Be Taken?
Harvoni is a two-drug fixed-dose combination product that contains 90 mg of ledipasvir and 400 mg of sofosbuvir in a single tablet. The recommended dosage of Harvoni is one tablet taken orally once daily with or without food.
How Should Vosevi Be Taken?
All patients should be tested for evidence of current or prior HBV infection by measuring hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (anti-HBc) before initiating HCV treatment with Vosevi. The recommended dosage of Vosevi is one tablet (400 mg of sofosbuvir, 100 mg of velpatasvir, and 100 mg of voxilaprevir) taken orally once daily with food.
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Gilead. Vosevi Prescribing Information.