Harvoni vs. Zepatier

Are Harvoni and Zepatier the Same Thing?

Harvoni (ledipasvir and sofosbuvir) and Zepatier (elbasvir and grazoprevir) are combinations of antiviral agents used to treat chronic hepatitis C (CHC) genotype 1 infection in adults.

Zepatier is also used to treat chronic HCV genotype 4 infection in adults.

Side effects of Harvoni and Zepatier that are similar include fatigue, headache, nausea, and diarrhea.

Side effects of Harvoni that are different from Zepatier include insomnia and weakness.

Side effects of Zepatier that are different from Harvoni include abdominal pain, shortness of breath, rash or itching, irritability, joint pain, depression, and anemia.

Harvoni may interact with rifampin and St. John's wort.

Zepatier may interact with nafcillin, ketoconazole, bosentan, tacrolimus, HIV/AIDS medications, statin drugs, and modafinil.

What Are Possible Side Effects of Harvoni?

Common side effects of Harvoni include:

  • fatigue,
  • headache,
  • nausea,
  • diarrhea,
  • insomnia, and
  • weakness.

What Are Possible Side Effects of Zepatier?

Common side effects of Zepatier include:

  • fatigue,
  • headache,
  • nausea,
  • abdominal pain,
  • diarrhea,
  • shortness of breath,
  • rash or itching,
  • irritability,
  • joint pain,
  • depression, or
  • anemia.

What Is Harvoni?

Harvoni (ledipasvir and sofosbuvir) is a direct-acting antiviral agent used to treat chronic hepatitis C (CHC) genotype 1 infection in adults.

What Is Zepatier?

Zepatier (elbasvir and grazoprevir) is a fixed-dose combination product containing a hepatitis C virus (HCV) NS5A inhibitor and an HCV NS3/4A protease inhibitor indicated with or without ribavirin for treatment of chronic HCV genotypes 1 or 4 infection in adults.

QUESTION

Hepatitis C virus causes an infection of the ______________. See Answer

What Drugs Interact With Harvoni?

Harvoni may interact with rifampin, and St. John's wort. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plant to become pregnant before using Harvoni. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Zepatier?

Zepatier may interact with nafcillin, ketoconazole, bosentan, tacrolimus, HIV/AIDS medications, statin drugs, and modafinil. Tell your doctor all medications and supplements you use.

How Should Harvoni Be Taken?

Harvoni is a two-drug fixed-dose combination product that contains 90 mg of ledipasvir and 400 mg of sofosbuvir in a single tablet. The recommended dosage of Harvoni is one tablet taken orally once daily with or without food.

How Should Zepatier Be Taken?

The recommended dosage of Zepatier is one tablet taken orally once daily with or without food.

SLIDESHOW

Hepatitis: How Do You Get Hepatitis A, B, and C? See Slideshow
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
Gilead. Harvoni Product Information.

www.harvoni.com/?

Merck. Zepatier Prescribing Information.

https://www.merck.com/product/usa/pi_circulars/z/zepatier/zepatier_pi.pdf

Health Solutions From Our Sponsors