Last updated on RxList: 10/9/2020
Hemabate Side Effects Center

What Is Hemabate?

Hemabate (carboprost tromethamine) Sterile Solution is a form of prostaglandin (a hormone-like substance that occurs naturally in the body) used to treat severe bleeding after childbirth (postpartum). Hemabate is also used to produce an abortion by causing uterine contractions. Hemabate is usually given between the 13th and 20th weeks of pregnancy, but may be given at other times for medical reasons. Hemabate is often used when another method of abortion has not completely emptied the uterus, or when a complication of pregnancy would cause the baby to be born too early to survive.

What Are Side Effects of Hemabate?

Common side effects of Hemabate include:

  • mild fever that may come and go,
  • chills,
  • numbness,
  • tingly feeling,
  • nausea,
  • diarrhea,
  • cough,
  • headache,
  • breast pain or tenderness,
  • menstrual type pain, or
  • ringing in your ears.

Tell your doctor if you have serious side effects of Hemabate including:

Dosage for Hemabate

To treat refractory postpartum uterine bleeding, an initial dose of 250 mcg of Hemabate Sterile Solution (1 mL) is given deep, intramuscularly. For abortion and other indications, an initial dose of 1 mL (250 mcg) is administered deep in the muscle. Subsequent doses of 250 mcg are administered at 1½ to 3½ hour intervals depending on uterine response.

What Drugs, Substances, or Supplements Interact with Hemabate?

Hemabate may interact with dinoprostone, mifepristone, misoprostol, or oxytocin. Tell your doctor all medications you are taking.

Hemabate During Pregnancy and Breastfeeding

During pregnancy, Hemabate should be used only if prescribed. There is no information on this medication and whether it passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Hemabate (carboprost tromethamine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


The first sign of pregnancy is most often: See Answer
Hemabate Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe pelvic pain, cramping, or vaginal bleeding;
  • high fever;
  • a light-headed feeling, like you might pass out;
  • shortness of breath
  • severe nausea, vomiting, or diarrhea; or
  • increased high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain).

Common side effects may include:

  • mild nausea, vomiting, diarrhea;
  • mild fever, chills;
  • flushing (warmth, redness, or tingly feeling);
  • cough, hiccups;
  • headache; or
  • mild pelvic pain or menstrual-type cramps.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Hemabate (Carboprost Tromethamine)


13 Early Signs & Symptoms of Pregnancy See Slideshow
Hemabate Professional Information


The adverse effects of HEMABATE Sterile Solution are generally transient and reversible when therapy ends. The most frequent adverse reactions observed are related to its contractile effect on smooth muscle.

In patients studied, approximately two-thirds experienced vomiting and diarrhea, approximately onethird had nausea, one-eighth had a temperature increase greater than 2° F, and one-fourteenth experienced flushing.

The pretreatment or concurrent administration of antiemetic and antidiarrheal drugs decreases considerably the very high incidence of gastrointestinal effects common with all prostaglandins used for abortion. Their use should be considered an integral part of the management of patients undergoing abortion with HEMABATE.

Of those patients experiencing a temperature elevation, approximately one-sixteenth had a clinical diagnosis of endometritis. The remaining temperature elevations returned to normal within several hours after the last injection.

Adverse effects observed during the use of HEMABATE for abortion and for hemorrhage, not all of which are clearly drug related, in decreasing order of frequency include:

Vomiting Nervousness
Diarrhea Nosebleed
Nausea Sleep disorders
Flushing or hot flashes Dyspnea
Chills or shivering Tightness in chest
Coughing Wheezing
Headaches Posterior cervical perforation
Endometritis Weakness
Hiccough Diaphoresis
Dysmenorrhea-like pain Dizziness
Paresthesia Blurred vision
Backache Epigastric pain
Muscular pain Excessive thirst
Breast tenderness Twitching eyelids
Eye pain Gagging, retching
Drowsiness Dry throat
Dystonia Sensation of choking
Asthma Thyroid storm
Injection site pain Syncope
Tinnitus Palpitations
Vertigo Rash
Vaso-vagal syndrome Upper respiratory infection
Dryness of mouth Leg cramps
Hyperventilation Perforated uterus
Respiratory distress Anxiety
Hematemesis Chest pain
Taste alterations Retained placental fragment
Urinary tract infection Shortness of breath
Septic shock Fullness of throat
Torticollis Uterine sacculation
Lethargy Faintness, light-headedness
Hypertension Uterine rupture
Pulmonary edema  
Endometritis from IUCD  

The most common complications when HEMABATE was utilized for abortion requiring additional treatment after discharge from the hospital were endometritis, retained placental fragments, and excessive uterine bleeding, occurring in about one in every 50 patients.

Post-Marketing Experience

Hypersensitivity reactions (e.g. Anaphylactic reaction, Anaphylactic shock, Anaphylactoid reaction, Angioedema).

Read the entire FDA prescribing information for Hemabate (Carboprost Tromethamine)

© Hemabate Patient Information is supplied by Cerner Multum, Inc. and Hemabate Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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