Medical Editor: John P. Cunha, DO, FACOEP
Hep-Lock U/P Preservative-Free (heparin lock flush) Solution is an anticoagulant used to keep IV catheters open and flowing freely. The brand name Hep-Lock U/P Preservative-Free is discontinued, but generic versions may be available. Many people using Hep-Lock U/P Preservative-Free do not have serious side effects. Uncommon but serious side effects of Hep-Lock U/P Preservative-Free (heparin lock flush) Solution include:
- signs of bleeding such as unusual pain/swelling/discomfort
- prolonged bleeding from cuts or gums
- persistent nosebleeds
- unusually heavy/prolonged menstrual periods
- unusual/easy bruising
- dark urine
- black stools
- severe headache, or
- unusual dizziness
Dosage of Hep-Lock U/P is determined by a physician. Hep-Lock U/P may interact with other anticoagulants, antiplatelet drugs, NSAIDs, mifepristone, doxorubicin, droperidol, ciprofloxacin, and mitoxantrone. Tell your doctor all medications and supplements you use. During pregnancy, Hep-Lock U/P should be used only if prescribed. This medication does not pass into breast milk. Consult your doctor before breastfeeding.
Our Hep-Lock U/P Preservative-Free (heparin lock flush) Solution Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Although very unlikely, this medication can cause bleeding if its effect on your clotting proteins is too much. Tell your doctor right away if you develop any signs of serious bleeding, including unusual pain/swelling/discomfort, prolonged bleeding from cuts or gums, persistent nosebleeds, unusually heavy/prolonged menstrual periods, unusual/easy bruising, dark urine, black stools, severe headache, unusual dizziness.
Some patients can have certain bad reactions to heparin (heparin-induced thrombocytopenia-HIT or heparin-induced thrombocytopenia and thrombosis-HITT). This can occur during treatment and up to several weeks after treatment with heparin has stopped.
Get medical help right away if you have any very serious side effects, including: pain/loss of feeling in the arms/legs, change in color of the arms/legs, chest pain, trouble breathing, confusion, weakness on one side of the body, slurred speech, vision changes.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Heparin Lock Preservative Free (Preservative-Free Heparin Lock Flush Solution)
Hemorrhage is the chief complication that may result from heparin use (see WARNINGS, Hemorrhage). An overly prolonged clotting time or minor bleeding during therapy can usually be controlled by withdrawing the drug (see OVERDOSAGE).
Thrombocytopenia, Heparin-induced Thrombocytopenia (HIT) and Heparin-induced Thrombocytopenia and Thrombosis (HITT) and Delayed Onset of HIT and HITT
Local irritation and erythema have been reported with the use of Heparin Lock Flush Solution.
Generalized hypersensitivity reactions have been reported, with chills, fever and urticaria as the most usual manifestations, and asthma, rhinitis, lacrimation, headache, nausea and vomiting, and anaphylactoid reactions, including shock, occurring more rarely. Itching and burning, especially on the plantar side of the feet, may occur.
Thrombocytopenia has been reported to occur in patients receiving heparin, with a reported incidence of 0 to 30%. While often mild and of no obvious clinical significance, such thrombocytopenia can be accompanied by severe thromboembolic complications such as skin necrosis, gangrene of the extremities that may lead to amputation, myocardial infarction, pulmonary embolism, stroke, and possibly death. (See WARNINGS and PRECAUTIONS.)
Certain episodes of painful, ischemic and cyanosed limbs have in the past been attributed to allergic vasospastic reactions. Whether these are in fact identical to the thrombocytopenia-associated complications remains to be determined.
Read the entire FDA prescribing information for Heparin Lock Preservative Free (Preservative-Free Heparin Lock Flush Solution)
© Heparin Lock Preservative Free Patient Information is supplied by Cerner Multum, Inc. and Heparin Lock Preservative Free Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.