Hepflush Side Effects Center

Last updated on RxList: 3/5/2009
Hepflush Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 3/21/2016

Hepflush-10 (heparin lock flush solution) is an anticoagulant used to maintain patency of an indwelling venipuncture device designed for intermittent injection or infusion therapy or blood sampling. Hepflush-10 solution may be used following initial placement of the device in the vein, after each injection of a medication or after withdrawal of blood for laboratory tests. Hepflush-10 is not to be used for anticoagulant therapy. Common side effects of Hepflush-10 include:

  • bleeding
  • hypersensitivity reactions
  • chills
  • fever
  • hives
  • asthma
  • unny or stuffy nose
  • tearing
  • headache
  • nausea
  • vomiting, and
  • itching and burning sensation on the feet

Dose of Hepflush-10 is determined by a physician. Hepflush-10 may interact with acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine, digitalis, tetracyclines, nicotine, or antihistamines. Tell your doctor all medications and supplements you use. During pregnancy, Hepflush-10 should be used only if prescribed. This drug does not pass into breast milk. Consult your doctor before breastfeeding.

Our Hepflush-10 (heparin lock flush solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Hepflush Consumer Information

Get emergency medical help if you have signs of an allergic reaction: nausea, vomiting, sweating, hives, itching, trouble breathing, swelling of your face, lips, tongue, or throat, or feeling like you might pass out.

Heparin flush can cause bleeding. Call your doctor at once if you have easy bruising or unusual bleeding, such as a nosebleed, black or bloody tarry stools, or any bleeding that will not stop.

Stop using heparin flush and call your doctor at once if you have:

  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot in the lung--chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;
  • signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs;
  • a light-headed feeling, like you might pass out;
  • skin changes in your arms, legs, hands, or feet; or
  • (in an infant) extreme drowsiness, weakness, or gasping for breath.

Less serious side effects are more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Hepflush (Heparin Lock Flush Solution)


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Hepflush Professional Information



Hemorrhage is the chief complication that may result from heparin use (see WARNINGS). An overly prolonged clotting time or minor bleeding during therapy can usually be controlled by withdrawing the drug (see OVERDOSAGE).

Thrombocytopenia, Heparin-induced Throm-bocytopenia (HIT) and Heparin-induced Throm-bocytopenia and Thrombosis (HITT) and Delayed Onset of HIT and HITT


Local irritation and erythema have been reported with the use of heparin lock flush solution.


Generalized hypersensitivity reactions have been reported, with chills, fever and urticaria as the most usual manifestations, and asthma, rhinitis, lacrima-tion, headache, nausea and vomiting, and ana-phylactoid reactions, including shock, occurring more rarely. Itching and burning, especially on the plantar side of the feet, may occur.

Thrombocytopenia has been reported to occur in patients receiving heparin, with a reported incidence of 0 to 30%. While often mild and of no obvious clinical significance, such thrombocytopenia can be accompanied by severe thromboembolic complications such as skin necrosis, gangrene of the extremities that may lead to amputation, myocar-dial infarction, pulmonary embolism, stroke, and possibly death (see WARNINGS, PRECAUTIONS).

Certain episodes of painful, ischemic and cyanosed limbs have in the past been attributed to allergic vasospastic reactions. Whether these are in fact identical to the thrombocytopenia-associated complications remains to be determined.

Read the entire FDA prescribing information for Hepflush (Heparin Lock Flush Solution)

© Hepflush Patient Information is supplied by Cerner Multum, Inc. and Hepflush Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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