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HIV and AIDS: Antiretroviral Drugs, Treatments and Medications (cont.)

Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

NRTIs block an enzyme of the HIV called reverse transcriptase that allows HIV to infect human cells, particularly CD4 T cells or lymphocytes. Reverse transcriptase converts HIV genetic material, which is RNA, into human genetic material, which is DNA. The human-like DNA of HIV then becomes part of the infected person's own cells, allowing the cell to produce RNA copies of the HIV that can then go on to attack other not yet infected cells. Thus, blocking reverse transcriptase prevents HIV from taking over (infecting) human cells.

Brand Name Generic Names Manufacturer
Combivir lamivudine and zidovudine GlaxoSmithKline
Emtriva emtricitabine, FTC Gilead Sciences
Epivir lamivudine, 3TC GlaxoSmithKline
Epzicom abacavir and lamivudine GlaxoSmithKline
Hivid zalcitabine, dideoxycytidine, ddC Hoffmann-La Roche
Retrovir zidovudine, azidothymidine, AZT, ZDV GlaxoSmithKline
Trizivir abacavir, zidovudine, and lamivudine GlaxoSmithKline
Truvada tenofovir disoproxil fumarate and emtricitabine tenofovir disoproxil fumarate and emtricitabine
Videx EC enteric coated didanosine, ddI EC Bristol Myers-Squibb
Videx didanosine, dideoxyinosine, ddI Bristol Myers-Squibb
Viread tenofovir disoproxil fumarate, TDF Gilead
Zerit stavudine, d4T Bristol Myers-Squibb
Ziagen abacavir sulfate, ABC GlaxoSmithKline

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