How Do Alpha1 Blockers Work?

Reviewed on 1/21/2022

How do alpha1 blockers work?

Alpha1 blockers are medications prescribed to treat bladder outlet obstruction due to prostate enlargement (benign prostatic hyperplasia) in men. Alpha1 blockers relax the smooth muscles in the bladder neck and prostate, which improves urine flow and reduces urinary symptoms associated with prostate enlargement.

Alpha1 blockers relax the prostate and bladder muscles by selectively blocking alpha1A and alpha1D adrenoreceptors. Alpha1A and alpha1D adrenoreceptors are protein molecules on the smooth muscle cells of the prostate, bladder, and urethra, which stimulate muscle contraction when activated by the hormones, epinephrine, and norepinephrine.

How are alpha1 blockers used?

Alpha1 blockers are administered as oral capsules for the treatment of the following conditions:



  • Bladder outlet obstruction
  • Ureteral stones, to facilitate kidney stone expulsion

What are side effects of alpha1 blockers?

Side effects of alpha1 blockers may include the following:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What are names of some alpha1 blocker drugs?

Generic and brand names of alpha1 blocker drugs include:


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