How Do Angiotensin II Agonists Work?

Reviewed on 5/17/2021

WHAT ARE ANGIOTENSIN II AGONISTS AND HOW DO THEY WORK?

Angiotensin agonists are a class of drugs used to increase blood pressure in adults with septic or distributive shock. Angiotensin agonists are drugs or naturally occurring substances that stimulate a receptor called the AT1 receptor. Angiotensin II is a peptide hormone of the renin-angiotensin-aldosterone system (RAAS) system. RAAS system plays a crucial role in the regulation of blood pressure in the body. Renin is an enzyme produced by the kidney, which acts on a blood protein to produce angiotensin.

The RAAS system regulates blood pressure by two important steps:

  • Conversion of angiotensin I to active angiotensin II with the help of an enzyme known as angiotensin-converting enzyme (ACE).
  • Angiotensin II interacts with the AT1 receptor to raise blood pressure.

In people with sepsis, there is a dysfunction of ACE enzyme and lowering of angiotensin II levels. As a result, the blood vessel dilates and blood pressure lowers drastically. Angiotensin agonists stimulate the AT1 receptor and constrict the blood vessel to raise blood pressure.

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HOW ARE ANGIOTENSIN II AGONISTS USED?

Angiotensin II agonists are indicated to:

  • Increase blood pressure in adults with septic shock or other distributive shock

WHAT ARE SIDE EFFECTS OF ANGIOTENSIN II AGONISTS?

The side effects of angiotensin agonists include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Benzodiazepines may cause physical dependence. Hence, never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE DRUG NAMES OF ANGIOTENSIN II AGONISTS?

Drug names include:

  • Giapreza
  • Synthetic human angiotensin II

QUESTION

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References
https://reference.medscape.com/drugs/angiotensin-ii-agonists

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067786/

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