How Do Antihistamine/Decongestant Combos Work?

Reviewed on 9/17/2021

HOW DO ANTIHISTAMINE/DECONGESTANT COMBOS WORK?

Antihistamine/decongestant combos work to relieve:

Antihistamines block the release of a chemical called histamine. Histamine is responsible for the constriction of respiratory smooth muscles, leading to congestion. Antihistamines do not allow histamine to constrict the respiratory muscles.

Decongestants work in the following ways:

  • Relieve irritation of upper respiratory tract infection
  • Reduce swelling of the inner lining of the nose
  • Relieve nasal congestion
  • Reduce increased blood flow to the tissues

HOW ARE ANTIHISTAMINE/DECONGESTANT COMBOS USED?

Antihistamine/decongestant combos are used for treating:

  • Seasonal allergic rhinitis 
  • Nasal congestion
  • Nasal congestion with rhinitis
  • Nasal congestion or sneezing due to common cold, hay fever, and allergic rhinitis
  • Cold 
  • Rhinitis/decongestant

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WHAT ARE SIDE EFFECTS OF ANTIHISTAMINE/DECONGESTANT COMBOS?

Antihistamine/decongestant combos can cause the following side effects:

  • Fever
  • Irritability
  • Headache
  • Diarrhea
  • Cough
  • Upper tract respiratory infection
  • Dry mouth
  • Muscle pain
  • Fatigue
  • Sleepiness
  • Indigestion
  • Dysmenorrhea
  • Dizziness 
  • Rash
  • Rash
  • Redness
  • Nausea
  • Vomiting
  • Irregular heart rate
  • Low blood pressure
  • Weight loss
  • Nervousness
  • Insomnia
  • Blurred vision
  • Drowsiness
  • Constipation
  • Stomach upset

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE DRUG NAMES OF ANTIHISTAMINE/DECONGESTANT COMBOS?

Generic and brand names of antihistamine/decongestant combos include:

References
https://reference.medscape.com/drugs/antihistamine-decongestant-combos

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