How Do Antiprotozoal Agents Work?

Reviewed on 10/22/2021

HOW DO ANTIPROTOZOAL AGENTS WORK?

Antiprotozoal agents are a class of drugs used to treat infections caused by protozoa, which are single-cell organisms, belonging to a group of parasites. Protozoans typically are microscopic and similar to plants and animals as they are eukaryotes, thus having a clearly defined cell nucleus. Antiprotozoals are effective in treating diseases such as African Trypanosomiasis (sleeping sickness) and Chagas disease (an inflammatory, infectious disease caused by the parasite Trypanosoma cruzi).

African Trypanosomiasis (sleeping sickness) is caused by Trypanosoma brucei, transmitted by the tsetse fly and characterized by symptoms such as:

Antiprotozoal drugs are prescription-only medicines and are available in various dosage forms such as tablets and capsules, usually taken three times a day with food. They are also available as a powder for preparing an injectable solution.

Antiprotozoal agents work in the following ways:

  • Antiprotozoal agents destroy protozoa or inhibit their growth and ability to reproduce.
  • They damage the protozoal DNA to limit the spread of infection.
  • They inhibit a fundamental pathway of energy metabolism (inhibition of parasite dehydrogenase activity) in the protozoa, thus making them unable to grow and reproduce.

HOW ARE ANTIPROTOZOAL AGENTS USED?

Antiprotozoal agents are used in conditions such as:

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WHAT ARE SIDE EFFECTS OF ANTIPROTOZOAL AGENTS?

Common side effects include:

Other rare side effects include:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF ANTIPROTOZOAL AGENTS?

Drug names include:

References
https://reference.medscape.com/drugs/antiprotozoal-agents

https://www.webmd.com/drugs/2/drug-179881/nifurtimox-oral/details

https://www.rxlist.com/consumer_suramin/drugs-condition.htm

https://www.rxlist.com/consumer_arsobal_melarsoprol/drugs-condition.htm

https://www.cdc.gov/parasites/sleepingsickness/gen_info/faqs-east.html

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