How Do ARB-CCB Combos Work?

Reviewed on 6/18/2021

HOW DO ARB/CCB COMBOS WORK?

Angiotensin receptor blocker/calcium channel blocker (ARB/CCB) combination drugs are used for the treatment of hypertension (high blood pressure). Hypertension is one of the major risk factors for cardiovascular disease, kidney disease, and stroke.

ARBs or angiotensin II receptor antagonists work by reducing the activity of angiotensin II (a hormone that narrows your blood vessels and contributes to salt and water retention in the body). They block the receptors that the hormone acts on, particularly AT1 receptors, which are found in the heart, blood vessels and kidneys. Blocking the activity of angiotensin II helps to lower blood pressure.

CCBs also known as calcium channel antagonists work by blocking the entry of calcium into the cells through voltage-gated calcium channels present in the smooth muscle of arteries. This causes dilation of the arteries, an increase in the free flow of blood, and a subsequent reduction in blood pressure.

HOW ARE ARB/CCB COMBOS USED?

  • ARB/CCB combos may be administered simultaneously with other antihypertensive agents to treat hypertension (high blood pressure).

WHAT ARE SIDE EFFECTS OF ARB/CCB COMBOS?

Side effects associated with ARB/CCB combos include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

SLIDESHOW

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WHAT ARE NAMES OF ARB/CCB COMBOS?

Generic and brand names of ARB/CCB combos drugs include:

References
https://reference.medscape.com/drugs/arb-ccb-combos

https://pubmed.ncbi.nlm.nih.gov/19433970/

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