HOW DO ARB/RENIN INHIBITOR COMBOS WORK?
Angiotensin II receptor blocker (ARB)/renin inhibitor combination drugs are used for the treatment of hypertension (high blood pressure). Hypertension is one of the major risk factors for cardiovascular disease, kidney disease, and stroke.
ARBs or angiotensin II receptor antagonists work by reducing the activity of angiotensin II (a hormone that narrows your blood vessels and contributes to salt and water retention in the body). They block the receptors that the hormone acts on, particularly AT1 receptors, which are found in the heart, blood vessels and kidneys. Blocking the activity of angiotensin II helps to lower blood pressure.
Renin inhibitors or direct renin inhibitors affect the renin-angiotensin-aldosterone system. Renin inhibitors work by directly inhibiting proteolytic enzyme renin released by the kidney and prevent renin from converting angiotensin to angiotensin I which further converts into angiotensin II. In the absence of angiotensin II, the blood pressure decreases as the blood vessels remain dilated and the flow of blood is maintained.
HOW ARE ARB/RENIN INHIBITOR COMBOS USED?
- ARB/renin inhibitor combos are given orally to treat hypertension (high blood pressure)
WHAT ARE SIDE EFFECTS OF ARB/RENIN INHIBITOR COMBOS?
Side effects associated with ARB/renin inhibitor combos include:
- Muscle cramps
- Flu-like symptoms
- Abdominal pain
- Gastroesophageal reflux disease (burning sensation in the chest caused by the acid that flows up from the stomach to the esophagus)
- Hypotension (low blood pressure)
- Angioedema (abrupt and short-lived swelling of the skin and mucous membranes)
- Allergic reactions
- Paresthesia (tingling or prickling, “pins-and-needles” sensation; usually temporary, often occurs in the arms, hands, legs or feet.)
- Shortness of breath
- Syncope (loss of consciousness)
- Kidney impairment (functional abnormalities in kidneys)
The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.