How Do Bile Acid Sequestrants Work?

Reviewed on 6/3/2021

WHAT ARE BILE ACID SEQUESTRANTS AND HOW DO THEY WORK?

Bile acid sequestrants or resins are medications for lowering low-density lipoprotein (LDL) cholesterol often called “bad” cholesterol in the blood. They bind to bile acids and prevent reabsorption of bile acids in the intestines. This interrupts the circulation of bile acids between the liver and gut and forces the liver to produce more bile acids. The liver produces bile acids by metabolizing cholesterol (LDL) present in the cells, and thus, intracellular cholesterol (LDL) is reduced. Bile acid sequestrants may promote apoprotein A1 synthesis and increase good cholesterol, high-density lipoprotein levels.

HOW ARE BILE ACID SEQUESTRANTS USED?

In addition to hypercholesterolemia, bile acid sequestrants are used in conditions such as:

WHAT ARE SIDE EFFECTS OF BILE ACID SEQUESTRANTS?

Common side effects of bile acid sequestrants include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE DRUG NAMES OF BILE ACID SEQUESTRANTS?

Drug names include:

QUESTION

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References
https://reference.medscape.com/drugs/bile-acid-sequestrants

https://www.medicinenet.com/bile_acid_sequestrants/article.htm

https://care.diabetesjournals.org/content/34/Supplement_2/S244

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