How Do Biological Response Modifiers Work?

Reviewed on 10/29/2021

How Do Biological Response Modifiers Work?

Biological response modifiers (BRM) are drugs used to treat bladder cancer, reduce the frequency and severity of serious infections because of chronic granulomatous disease (an inherited immune system disease), renal cell carcinoma, hepatitis B and C infections, and Kaposi's sarcoma (a type of cancer that causes abnormal tissue growth on different parts of the body) related to acquired immunodeficiency syndrome.

BRM, also called immunotherapy, is a type of treatment that mobilizes the body's immune system to fight cancer. They can be both endogenous (produced naturally within the body) and exogenous (pharmaceutical drugs), and they can either enhance an immune response or suppress it.

BRMs are administered as a powder in a vial to mix with liquid and as a solution to inject either subcutaneously (under the skin), intramuscularly (into a muscle), intravenously (into the vein), or intralesionally (into a lesion).

BRMs work in the following ways:

  • They belong to a class of medications called “immunomodulators” that work by modifying the immune system to fight cancer cells.
  • They also belong to a class of drugs known as “cytokines.” They are a man-made version of a naturally occurring protein that stimulates the body to produce other chemicals which increase the body's ability to fight cancer.

How Are Biological Response Modifiers Used?

Biological response modifiers are used to treat conditions such as:


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What Are Side Effects of Biological Response Modifiers?

Some of the common side effects include:

Other rare side effects include:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What Are Names of Biological Response Modifiers?

Generic and brand names of biological response modifiers include:


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