How Do Bispecific T-cell Engager Antibodies Work?

Reviewed on 10/29/2021

How Do Bispecific T-cell Engager Antibodies Work?

Bispecific T-cell engager (BiTE) antibodies are a class of drugs used to treat Philadelphia chromosome-negative relapsed or refractory B-cell precursor acute lymphoblastic leukemia (a type of cancer of the white blood cells).

BiTE antibodies are artificial bispecific monoclonal antibodies that work by exerting action selectively and directing the human immune system to act against tumor cells. They activate endogenous T-cells by connecting CD3 in the T-cell receptor complex with CD19 on benign and malignant B cells. This mediates the formation of a synapse between the T cell and the tumor cell, upregulation of cell adhesion molecules, production of cytolytic proteins, release of inflammatory cytokines, and proliferation of T cells, which results in redirected lysis of CD19+ cells.

BiTE antibodies are administered via slow injection (infusion) into a vein through a special machine (infusion pump), typically over four weeks (28 days), followed by two to eight weeks when the medication is not given. This treatment period is called a cycle, and the cycle may be repeated as necessary.

BiTE antibodies work in the following ways:

  • They work by slowing or stopping the growth of cancer cells in the body.
  • They direct a host's immune system, more specifically the T cells’ cytotoxic activity against cancer cells.

How Are Bispecific T-cell Engager Antibodies Used?

BiTE antibodies are used to treat relapsed or refractory B-cell precursor acute lymphoblastic leukemia.

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What Are Side Effects of Bispecific T-cell Engager Antibodies?

Some of the common side effects include:

Other rare side effects include:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What Are Names of Bispecific T-cell Engager Antibodies?

Generic and brand names of BiTE antibodies include:

References
https://reference.medscape.com/drugs/bispecific-t-cell-engager-bite-antibodies

https://www.rxlist.com/blincyto-drug.htm

https://www.webmd.com/drugs/2/drug-167430/blinatumomab-intravenous/details

https://medlineplus.gov/druginfo/meds/a614061.html

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