How Do BPH Alpha Blockers Work?

Reviewed on 12/6/2021

How do BPH alpha blockers work?

Benign prostatic hyperplasia (BPH) alpha-blockers are medications used to treat urinary symptoms associated with BPH and to reduce blood pressure in people with hypertension. BPH alpha blockers relax the smooth muscles in the bladder neck and prostate, and the smooth muscles around arteries and veins.

BPH alpha blockers relax the prostate and bladder neck muscles by blocking alpha1 adrenoreceptors, protein molecules that stimulate muscle contraction when activated by the hormones, epinephrine, and norepinephrine. Some BPH alpha-blockers selectively block alpha1A receptors, a subtype that is predominant in the prostate.

Most of the alpha1 receptors are located on the smooth muscles of the prostate, and vascular smooth muscles in the skin, sphincter muscles in the gastrointestinal system, kidney, and brain. Blocking alpha1 receptors improves urine flow, reduces the urinary symptoms associated with prostate enlargement, and lowers blood pressure.

How are BPH alpha blockers used?

BPH alpha-blockers are administered as oral tablets or capsules for the treatment of the following conditions:

FDA-approved:

Off-label:

What are side effects of BPH alpha blockers?

Side effects of BPH alpha-blockers may include the following:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What are names of some BPH alpha blocker drugs?

Generic and brand names of BPH alpha-blocker drugs include:

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References
https://reference.medscape.com/drugs/bph-alpha-blockers

https://www.ncbi.nlm.nih.gov/books/NBK556066/

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