How Do Carbapenems Work?

Reviewed on 11/19/2021

HOW DO CARBAPENEMS WORK?

Carbopenems are a class of drugs used to treat a wide variety of bacterial infections (including Escherichia coliKlebsiella pneumoniae, and Enterobacter cloaca) of the skinlungs, stomachpelvisurinary tract, and kidneys.

They are also used for the treatment of complicated intra-abdominal infections, complicated urinary tract infections including pyelonephritis (a bacterial infection causing inflammation of the kidneys), gynecological, bone and joint infections, skin and skin structure infections, and endocarditis (a life-threatening inflammation of the inner lining of the heart's chambers and valves).

Carbapenems are a subclass of antibiotics called beta-lactam antibiotics (that have a chemical structure called a beta-lactam ring). They are effective against many aerobic and anaerobic gram-positive and gram-negative organisms (classified depending on whether they get stained by a violet dye used inlaboratory test known as the gram stain test).

They bind to and block a type of enzyme called penicillin-binding proteins, which is responsible for peptidoglycan cross-linking during the synthesis of the bacterial cell wall. Whenever a bacterial cell tries to synthesize a new cell wall to grow and divide, they interfere with their ability to form cell walls, inhibit the bacterial cell wall synthesis, render the cell vulnerable to osmotic disruption, and eventually kill them.

Carbopenems are administered via intramuscular (into a muscle) and intravenous (into a vein) routes.

SLIDESHOW

Fungal Skin Infections: Types, Symptoms, and Treatments See Slideshow

HOW ARE CARBAPENEMS USED?

Carbopenems are used in conditions such as:

WHAT ARE SIDE EFFECTS OF CARBAPENEMS?

Side effects of carbopenems may include: 

Other rare side effects include:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF CARBAPENEMS?

Generic and brand names of carbapenems include:

References
https://reference.medscape.com/drugs/carbapenems

https://www.rxlist.com/invanz-drug.htm

https://www.rxlist.com/doribax-drug.htm#description

https://www.webmd.com/drugs/2/drug-148185/ertapenem-intravenous/details

https://medlineplus.gov/druginfo/meds/a608015.html

https://www.webmd.com/drugs/2/drug-2216/imipenem-cilastatin-intravenous/details

https://www.rxlist.com/recarbrio-drug.htm

https://medlineplus.gov/druginfo/meds/a696038.html

https://www.rxlist.com/merrem-iv-drug.htm

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