How Do Central Acetylcholinesterase Inhibitors Work?

Reviewed on 7/26/2021

HOW DO CENTRAL ACETYLCHOLINESTERASE INHIBITORS WORK?

Central acetylcholinesterase (AChE) inhibitors also known as cholinesterase inhibitors are drugs that prevent the breaking down of acetylcholine (ACh) and increase the duration of action and levels of ACh in the nerve endings called synapses. These drugs are used to treat Alzheimer’s disease and associated abnormalities such as:

ACh is an essential neurotransmitter released into space between two neurons (synaptic cleft) by the presynaptic neuron. It carries out various functions at neuromuscular junctions at synapses in the ganglia of the visceral motor system within the central nervous system (the brain and spinal cord). Some important functions of ACh in the central nervous system include:

AChE is concentrated in the synaptic cleft and hydrolyzes ACh into acetate and choline, decreasing ACh levels before it reaches the postsynaptic neuron. Centrally acting AChE inhibitors are selective and reversible inhibitors of AChE

HOW ARE CENTRAL ACETYLCHOLINESTERASE INHIBITORS USED?

Central AChE inhibitors are used to treat:

SLIDESHOW

Dementia, Alzheimer's Disease, and Aging Brains See Slideshow

WHAT ARE SIDE EFFECTS OF CENTRAL ACETYLCHOLINESTERASE INHIBITORS?

Side effects of central AChE inhibitors include:

Other serious side effects of central AChE inhibitors include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF CENTRAL ACETYLCHOLINESTERASE INHIBITORS?

Generic and brand names of central AChE inhibitors include:

References
https://reference.medscape.com/drugs/acetylcholinesterase-inhibitors-central

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648782/

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