HOW DO CENTRAL MONOAMINE-DEPLETING AGENTS WORK?
The exact mechanism of involuntary movement disorder is not well understood. However, excess dopamine or increased sensitivity of dopamine receptors has been known to play a dominant role in uncontrolled, involuntary movements.
Central monoamine-depleting agents inhibit vesicular monoamine transporter 2 (VMAT2), causing dopamine depletion in the central nervous system. VMAT2 is a protein that controls the amount of dopamine stored in the nerve cell and the amount released. Inhibiting VMAT2 leads to a lower amount of dopamine available, thereby reducing unwanted body movements.
HOW ARE CENTRAL MONOAMINE-DEPLETING AGENTS USED?
Central monoamine-depleting agents are a class of medications used for treating uncontrolled, involuntary movement disorders associated with:
- Huntington’s disease
- Tardive dyskinesias
- Tourette’s syndrome
WHAT ARE SIDE EFFECTS OF CENTRAL MONOAMINE-DEPLETING AGENTS?
Some of the common side effects of central monoamine-depleting agents include:
- Dry mouth
- Urinary tract infection
- Suicidal ideation
- Joint pain
The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.