How Do Dopamine Agonists Work?

Reviewed on 8/10/2021

HOW DO DOPAMINE AGONISTS WORK?

Dopamine agonists are a class of drugs used to treat the symptoms of Parkinson's disease. They mimic the action of naturally occurring dopamine.

The direct cause of Parkinson's disease or Parkinsonian-like syndrome is the deficiency of the neurotransmitter dopamine in the brain. Antiparkinson medicines aim to prolong the action of dopamine in the brain by:

Replacing dopamine

Inhibiting dopamine breakdown

Sensitizing dopamine receptors to stimulate dopamine release

Dopamine agonists bind to the dopamine receptors to release more dopamine in the brain.

HOW ARE DOPAMINE AGONISTS USED?

Dopamine agonists can be added to levodopa for the initial treatment of Parkinson's disease. However, these agents cannot be used to treat the disease in the advanced stages.

WHAT ARE SIDE EFFECTS OF DOPAMINE AGONISTS?

Dopamine agonists, when taken orally, can cause the following side effects:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF DOPAMINE AGONISTS?

Generic and brand names of dopamine agonists include:

QUESTION

Parkinson's disease is only seen in people of advanced age. See Answer
References
https://reference.medscape.com/drugs/antiparkinson-agents-comt-inhibitors

https://www.parkinson.org/Understanding-Parkinsons/Treatment/Prescription-Medications/COMT-Inhibitors

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