How Do First-generation Cephalosporins Work?

Reviewed on 5/6/2021

How Do First-generation Cephalosporins Work?

Cephalosporins are broad-spectrum antibiotics used to manage a wide range of bacterial infections. They are derived from the mold Acremonium (previously called Cephalosporium). Cephalosporins are grouped into five generations based on their spectrum of coverage against gram-positive and gram-negative bacteria. They are administered intravenously or orally depending on the infection.

First-generation cephalosporins act on all gram-positive bacteria such as staphylococci and streptococci and show little activity against gram-negative bacteria.

First-generation cephalosporins inhibit bacterial cell wall synthesis and have the same mode of action as other beta-lactam antibiotics (such as penicillins). They disrupt the synthesis of the peptidoglycan layer forming the bacterial cell wall. The peptidoglycan layer is important for cell wall structural integrity.

How Are First-generation Cephalosporins Used?

What Are Side Effects of First-generation Cephalosporins?

Side-effects associated with first-generation cephalosporins include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

QUESTION

Bowel regularity means a bowel movement every day. See Answer

What Are Names of First-generation Cephalosporins Drugs?

Drug names include:

References
https://reference.medscape.com/drugs/cephalosporins-1st-generation

https://www.ncbi.nlm.nih.gov/books/NBK551517/

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