How Do Gallstone Solubilizing Agents Work?

Reviewed on 7/6/2021

HOW DO GALLSTONE SOLUBILIZING AGENTS WORK?

Gallstone solubilizing agents are a class of medications used to dissolve small noncalcified gallstones (made up of cholesterol) in adults who do not want to or cannot have gallbladder surgery, to prevent gallstones in overweight or obese patients undergoing rapid weight loss and to treat primary biliary cirrhosis (PBC-an autoimmune liver disease). These agents are naturally occurring bile acids. Bile acids are hydroxylated steroids synthesized in the liver from cholesterol and secreted in small quantities into bile (a digestive fluid produced by the liver and stored in the gallbladder).

Gallstone solubilizing agents are administered orally in the form of capsules or tablets. They are usually taken two or three times a day with or without food to treat gallstones and two times a day to prevent gallstones in people who are losing weight quickly. For PBC, they are usually taken two or four times a day with food. 

Gallstone solubilizing agents work in the following ways:

  • These bile acid agents decrease the amount of cholesterol produced by the liver and its secretion in the bile by blocking an enzyme in the liver that is responsible for producing cholesterol (inhibition of hepatic cholesterol synthesis and secretion).
  • They also decrease the amount of cholesterol absorbed by the intestines.
  • They help in dissolving or breaking down the cholesterol in bile to prevent stone formation and promote the dissolution of cholesterol-containing gallstones.
  • In addition, they decrease the toxic levels of bile acids that accumulate in the liver in patients suffering from PBC.

HOW ARE GALLSTONE SOLUBILIZING AGENTS USED?

Gallstone solubilizing agents are used in conditions such as:

WHAT ARE SIDE EFFECTS OF GALLSTONE SOLUBILIZING AGENTS?

Common side effects include:

Other rare side effects include:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF GALLSTONE SOLUBILIZING AGENTS?

Genetic and brand names of gallstone solubilizing agents include:

SLIDESHOW

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References
https://reference.medscape.com/drugs/gallstone-solubilizing-agents

https://www.rxlist.com/consumer_ursodiol_actigall_urso_forte/drugs-condition.htm

https://www.webmd.com/drugs/2/drug-6665/ursodiol-oral/details

https://medlineplus.gov/druginfo/meds/a699047.html

https://www.medicinenet.com/ursodiol/article.htm#what_is_ursodiol_what_are_the_uses_for_ursodiol https://www.webmd.com/drugs/2/drug-153254/chenodiol-oral/details https://www.rxlist.com/chenodal-drug.htm#description

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